Coixol amplifies glucose-stimulated insulin secretion via cAMP mediated signaling pathway

Hameed, Abdul; Hafizur, Rahman M.; Khan, Majid; Jawed, Abira; Wang, Hao; Zhao, Miaomiao; Matsunaga, Kohichi; Izumi, Tetsuro; Siddiqui, S.; Khan, Faisal; Adhikari, Achyut; Sharma, Khaga Raj

doi:10.1016/j.ejphar.2019.172514

Cited by 22 publications

(19 citation statements)

References 24 publications

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“…However, whether this concentration shows certain toxicity was not mentioned. The concentration of coixol in the current study was higher than that in other in vitro studies [23,24]. The concentration difference may be related to the type of cells.…”

Section: Discussioncontrasting

confidence: 73%

“…Coixol is an extract from coix and has been studied for its bioactivity since the 1980s [19]. The reported biological activities of coixol include but are not limited to the regulation of reproductive behavior and hormones [20], antimicrobial and antitumor activity [21,22], inhibition of mucin secretion [23], and enhancement of insulin secretion [24]. The anti-inflammatory effect of coixol has not been reported, although some other extracts of coix have shown anti-inflammatory activity [17,25].…”

Section: Discussionmentioning

confidence: 99%

“…Further in vivo studies are indicated to investigate if coixol would be useful as a therapeutic anti-inflammatory agent. So far, the highest dosage of coixol in reported in vivo studies was 50 mg/kg (about 300 µM/kg) [24]. However, whether this concentration shows certain toxicity was not mentioned.…”

Section: Discussionmentioning

confidence: 99%

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Coixol Suppresses NF-κB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells

Zhou

Liu

et al. 2020

Molecules

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Coixol, a plant polyphenol extracted from coix (Coix lachryma-jobi L.var.ma-yuen Stapf), has not been investigated for its anti-inflammatory effect. In this study, using a lipopolysaccharide (LPS)-induced macrophage cell model, we observed that coixol can effectively reduce the expression of interleukin (IL)-1β, IL-6, IL-18, tumor necrosis factor (TNF)-α, nitric oxide (NO), inducible nitric oxide synthases (iNOS), and cyclooxygenase (COX)-2, but had no effect on the expression of the anti-inflammatory mediator IL-10. Furthermore, we found that coixol inhibits mitogen-activated protein kinases (MAPKs), nuclear transcription factor κ B (NF-κB) pathways, and NOD-like receptor protein (NLRP) 3 inflammasome activation. In conclusion, the present study demonstrates that coixol exerts certain anti-inflammatory effects by inhibiting the expression of pro-inflammatory mediators in vitro. The mechanism of this effect was in part related to its ability to inhibit the activation of NF-κB, MAPKs pathways, and NLRP3 inflammasome.

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Section: Discussioncontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Coixol Suppresses NF-κB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells

Zhou

Liu

et al. 2020

Molecules

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“…Coixol, an alkaloid from Scoparia dulcis , significantly improves glucose tolerance and fasting blood glucose levels in streptozotocin-induced diabetic SD rats. This progress is significantly inhibited by the PKA inhibitor H-89 (50 μM) and Epac2 inhibitor MAY0132 (50 μM), indicating that coixol enhances insulin secretion by the cAMP signaling pathway [ 50 ]. Therefore, in the pancreas, the dietary bioactive ingredients targeting cAMP provide a new strategy for the promotion of insulin secretion and protection of pancreatic islets.…”

Section: Pancreasmentioning

confidence: 99%

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Wang

Liu²,

Kang

et al. 2021

Nutrients

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As the prevalence of diabetes increases progressively, research to develop new therapeutic approaches and the search for more bioactive compounds are attracting more attention. Over the past decades, studies have suggested that cyclic adenosine monophosphate (cAMP), the important intracellular second messenger, is a key regulator of metabolism and glucose homeostasis in diverse physiopathological states in multiple organs including the pancreas, liver, gut, skeletal muscle, adipose tissues, brain, and kidney. The multiple characteristics of dietary compounds and their favorable influence on diabetes pathogenesis, as well as their intersections with the cAMP signaling pathway, indicate that these compounds have a beneficial effect on the regulation of glucose homeostasis. In this review, we outline the current understanding of the diverse functions of cAMP in different organs involved in glucose homeostasis and show that a diversity of bioactive ingredients from foods activate or inhibit cAMP signaling, resulting in the improvement of the diabetic pathophysiological process. It aims to highlight the diabetes-preventative or -therapeutic potential of dietary bioactive ingredients targeting cAMP signaling.

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“…41 Therefore, coixol enhanced insulin secretion via the cAMP-mediated pathway. 41 However, the effect has not been tested and confirmed in humans.…”

Section: Specific Substances In Coix Seedmentioning

confidence: 99%

Coix Seed May Affect Human Immune Function

Suzuki

Konaya

2021

Natural Product Communications

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Coix ( Coix lacryma-jobi Linné . var . mayuen Stapf) is, unlike many herbs used in Chinese traditional medicines, often used as a single agent. Coix seed has its specific constituents coixenolide and coixol. This review summarizes the effects of coix seed on human pathology and physiology, and the roles of coixenolide and coixol on the effects. The comprehensive literature search was conducted using PubMed, Citation Information by National Institute of Informatics of Japan (CiNii), University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR), and ClinicalTrials.gov databases. Some studies suggest that coix seed promotes the spontaneous regression of viral infections of the skin. Meanwhile, kanglite, a purified oil agent used for cancer therapy, has been implied to increase the ratio of CD4 + T cells in the peripheral blood of cancer patients undergoing treatment. These studies seem to indicate that coix seed may affect cellular immune function. However, there are limitations to the individual studies on which the above consideration is based, and thereby, it is not conclusive what specific immune or clinical indices coix seed affects. In addition, the effects of coixol on human immune function have not been clarified. Therefore, coix seed seems promising for health promotion and presents a challengeable and attractive theme for natural product chemists, pharmacologists, immunologists, and clinicians.

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Coixol amplifies glucose-stimulated insulin secretion via cAMP mediated signaling pathway

Cited by 22 publications

References 24 publications

Coixol Suppresses NF-κB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells

Coixol Suppresses NF-κB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Coix Seed May Affect Human Immune Function

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