Çok yüksek doz ketiapin alımı ile intihar girişimi / Suicide attempt with a very high dose of quetiapine

Çetin, Alptekin; Konuk, Numan

doi:10.5350/kpb-bcp201121111

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…Unintentional self-poisoning fatalities are classically related to substance abuse, mental health issues, and physical health problems; quetiapine is no exception. Fatalities—complex suicides and suicide attempts involving antipsychotic or sedative–hypnotic medications are frequently seen [ 35 , 36 , 37 ]. Poisoning homicides are rare, though they have been described, and quetiapine is used only to incapacitate the victim (as in pediatric homicides) [ 16 , 38 , 39 ].…”

Section: Use and Misusementioning

confidence: 99%

Quetiapine-Related Deaths: In Search of a Surrogate Endpoint

Šoša

2024

Toxics

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Quetiapine is a second-generation antipsychotic drug available for two and half decades. Due to increased misuse, prescription outside the approved indications, and availability on the black market, it is being encountered in medicolegal autopsies more frequently. For instance, it has been linked to increased mortality rates, most likely due to its adverse effects on the cardiovascular system. Its pharmacokinetic features and significant postmortem redistribution challenge traditional sampling in forensic toxicology. Therefore, a systematic literature review was performed, inclusive of PubMed, the Web of Science—core collection, and the Scopus databases; articles were screened for the terms “quetiapine”, “death”, and “autopsy” to reevaluate each matrix used as a surrogate endpoint in the forensic toxicology of quetiapine-related deaths. Ultimately, this review considers the results of five studies that were well presented (more than two matrices, data available for all analyses, for instance). The highest quetiapine concentrations were usually measured in the liver tissue. As interpreted by their authors, the results of the considered studies showed a strong correlation between some matrices, but, unfortunately, the studies presented models with poor goodness of fit. The distribution of quetiapine in distinct body compartments/tissues showed no statistically significant relationship with the length of the postmortem interval. Furthermore, this study did not confirm the anecdotal correlation of peripheral blood concentrations with skeletal muscle concentrations. Otherwise, there was no consistency regarding selecting an endpoint for analysis.

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