COL4A3 expression correlates with pathogenesis, pathologic behaviors, and prognosis of gastric carcinomas

Nie, Xin; Wang, Jianping; Zhu, Wan; Xu, Xiaowu; Xing, Yue; Yu, Miao; Liu, Yunpeng; Takano, Yasuo; Zheng, Haixue

doi:10.1016/j.humpath.2011.10.028

Cited by 40 publications

(30 citation statements)

References 27 publications

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“…Type IV collagen has been linked not only to specific kidney pathologies, such as the autosomal-recessive form of Alport syndrome (hereditary glomerulonephropathy) and familial benign hematuria (thin basement membrane disease), but also to tumor invasion and metastasis, including gastric, colorectal, ovarian, and breast cancers, as well as welldifferentiated lung carcinomas. 35,36 It appears that type IV collagen could control reproductive function at different ontogenic times and anatomical sites and plays functional roles in cell adhesion, cell differentiation, and tissue development. 37,38 In our study, we observed a significant downregulation of COL4A3 (fold change = −4.10, P = 0.017) and COL4A4 (fold change = −1.56, P = 0.003) in CVSs, which also suggested that those two genes may be involved in the cystic formation of VS.…”

Section: Discussionmentioning

confidence: 99%

Mutation spectrum and differential gene expression in cystic and solid vestibular schwannoma

Zhang

Wang

Sun

et al. 2014

Genetics in Medicine

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Section: Discussionmentioning

confidence: 99%

Mutation spectrum and differential gene expression in cystic and solid vestibular schwannoma

Zhang

Wang

Sun

et al. 2014

Genetics in Medicine

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“…The mRNA and protein expression of WAVE3 in these six kinds of human gastric-cancer cell lines were all higher than that in normal gastric-mucosa cell line. 16 (Po0.01). Furthermore, a correlation was found between aggressiveness of the cell line and expression of WAVE3 in these six kinds of gastric-cancer cell lines, MGC803 cells with high aggressive ability revealed higher WAVE3 mRNA and protein expression, whereas SGC-7901 with low aggressive ability showed the lowest WAVE3 mRNA-and protein-expression (Po0.05).…”

Section: Expression Of Wave3 In Human Gastric-cancer Cell Linesmentioning

confidence: 99%

WAVE3 promotes epithelial–mesenchymal transition of gastric cancer through upregulation of Snail

et al. 2014

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WAVE3, an actin cytoskeleton remodeling protein overexpressed in many kinds of cancers, has been associated with a lot of metastatic diseases. However, the role and mechanisms of the high expression of WAVE3 in human gastric cancer has not been fully elucidated. Here we demonstrated that WAVE3 was expressed in all six kinds of gastric-cancer cell lines: BGC-823, SGC-7901, AGS, MGC803, MKN28 and MKN45. Furthermore, a correlation was found between aggressiveness of these cell lines and expression of WAVE3. Next, we investigated the role of WAVE3 in SGC-7901 cells and found that upregulating WAVE3 could promote the migration, invasion and proliferation of SGC-7901 cells in vitro. It has been reported that WAVE3 could induce cancer invasion and metastasis by participating epithelial-mesenchymal transition (EMT). However, the mechanisms are not entirely clear. In this study we showed that elevated WAVE3 levels could induce EMT in SGC-7901 cells by dampening the expression of E-cadherin while increasing the expression of vimentin. Elevated WAVE3 levels could also improve the expression of transcription factor Snail. In addition, downregulating Snail could particularly reduce EMT and the metastasis, invasion and proliferation activity in SGC-7901 cells elevated by overexpression of WAVE3. Taken together, we demonstrated that WAVE3 promoted gastric-cancer-cells migration and invasion by taking part in EMT via upregulation of Snail. WAVE3 could be a useful target for gastric-cancer prevention and therapy.

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“…These 30 PA-associated genes have been implicated in different phenotypes in multiple GWASs and mouse model knockout systems. For example, COL4A3, part of the collagen trimerization and phospholipase-C pathways, has been linked to kidney diseases and cancers 71,72 , while SLC4A5, a sodium bicarbonate transporter has been associated with hypertension [73][74][75] . Overall, the PA genes have been associated with cardiovascular disease, adiposity, neurological, behavioral, and mortality and aging (See Supplementary File B for DisGeNET 76 results).…”

Section: Discussionmentioning

confidence: 99%

A transcript-wide association study in physical activity intervention implicates molecular pathways in chronic disease

Claypool

2018

Preprint

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BackgroundPhysical activity is associated with decreased risk for several chronic and acute conditions including obesity, diabetes, cardiovascular disease, mental health and aging. However, the biological mechanisms associated with this decreased risk are elusive. One way to ascertain biological changes influenced by physical activity is by monitoring changes in how genes are expressed. In this investigation, we conducted a transcriptome-wide association study of physical activity, meta-analyzing 20 independent studies to increase power for discovery of genes expressed before and after physical activity. Further, we hypothesize that genes identified in physical activity are expressed in obesity, inflammation, major depressive disorder and healthy aging. Results Our analysis identified thirty (30) transcripts induced by physical activity (PA signature), at an FDR < 0.05. Twenty (20) of these transcripts, including COL4A3, CAMKD1, SLC4A5, EPS15L1, RBM33, and CACNG1, are up-regulated and ten (10) transcripts including CRY1, ZNF346, SDF4, ANXA1 and YWHAZ are down-regulated. We find that several of these physical activity transcripts are associated and biologically concordant in direction with body mass index, white blood cell count, and healthy aging. Conclusions powerful approach, we found thirty genes that were putatively influenced by physical activity, eight of which are inversely associated with body mass index, thirteen inversely associated with white blood cell count, and three associated and concordant with healthy aging. One gene was significant and concordant with major depressive disorder. These results highlight the potential molecular basis for the protective benefit of physical activity for a broad set of chronic conditions.

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COL4A3 expression correlates with pathogenesis, pathologic behaviors, and prognosis of gastric carcinomas

Cited by 40 publications

References 27 publications

Mutation spectrum and differential gene expression in cystic and solid vestibular schwannoma

Mutation spectrum and differential gene expression in cystic and solid vestibular schwannoma

WAVE3 promotes epithelial–mesenchymal transition of gastric cancer through upregulation of Snail

A transcript-wide association study in physical activity intervention implicates molecular pathways in chronic disease

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