BackgroundScience studies have been a field of research for different knowledge areas, and they have been successfully used to analyse the construction of scientific knowledge, practice and dissemination. In this study, we aimed to verify how the Zika epidemic has moulded the scientific articles published worldwide by analysing international collaborations and the knowledge landscape through time, as well as research topics and country involvement. OPEN ACCESS Citation: Oliveira JFd, Pescarini JM, Rodrigues MdS, Almeida BdA, Henriques CMP, Gouveia FC, et al. (2020) The global scientific research response to the public health emergency of Zika virus infection. PLoS ONE 15(3): e0229790. https://doi.