Colcemid und Myleran in der Behandlung der chronischen Myelose

Abstract

Von den in den letzten Jahren entwickelten zytostatischen Medikamenten haben sich Colcemid und Myleran in der Behandlung der chronischen Myelose besonders bewährt.Den ersten Mitteilungen über Colcemid (= Demecolcin) von B o c k und Gross sowie Moeschlin, Meyerund Lichtmann sind inzwischen weitere von Storti und Gallinelli, Giganti,

Toxic epidermal necrolysis-like reaction secondary to colchicine overdose

“…Colchicine intoxication has been described in a variety of clinical settings, most commonly after suicidal intent 6–11 . Also reported are accidental or medicinal overdose, 1,12–23 homicidal poisoning, 24 mistaken ingestion of colchicine‐containing plants, 25–27 and high‐dose colchicine for cancer chemotherapy 28–32 …”

“…also described the presence of an erythematous dermatosis in a patient with colchicine toxicity; however, no biopsy was taken and no further details of the exanthem were described 62 . In older French 65 and German articles 29–31 three colchicine‐toxic patients are described as having a pruritic, scarlitiniform rash. American authors describe three patients with a ‘maculopapular’ exanthem 13,15 , 16 .…”

“…Although typically diffuse, erythema localized to the scrotum has been reported 14 . Although a hypersensitivity has been suggested as causing the exanthem, 31 repeated courses of colchicine do not reproduce the rash 16,29 . Pruritus without rash, 29 generalized erythroderma 18 and a scaling dermatitis 25 have also been reported.…”