Colchicine does not inhibit secretin-induced choleresis in rats exhibiting hyperplasia of bile ductules: evidence against a pivotal role of exocytic vesicle insertion

Dällenbach, Andreas; Renner, Eberhard L.

doi:10.1016/0168-8278(95)80288-6

Cited by 5 publications

(2 citation statements)

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“…3) has been proposed in rat liver to explain the cooperative interactions between secretin and somatostatin in the regulation of ductal secretory activity. In contrast to these findings, other studies in rats showed that colchicine does not inhibit secretin-induced ductal secretion, thus providing evidence against a pivotal role of exocytic vesicle insertion into cholangiocyte apical membrane to explain the choleretic effect of secretin (49).…”

Section: Gastrointestinal Hormonescontrasting

confidence: 68%

Regulation of cholangiocyte bicarbonate secretion

Kanno

LeSage²,

Glaser³

et al. 2001

American Journal of Physiology-Gastrointestinal and Liver Physi

140

168

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The objective of this review article is to discuss the role of secretin and its receptor in the regulation of the secretory activity of intrahepatic bile duct epithelial cells (i.e., cholangiocytes). After a brief overview of cholangiocyte functions, we provide an historical background for the role of secretin and its receptor in the regulation of ductal secretion. We review the newly developed experimental in vivo and in vitro tools, which lead to understanding of the mechanisms of secretin regulation of cholangiocyte functions. After a description of the intracellular mechanisms by which secretin stimulates ductal secretion, we discuss the heterogeneous responses of different-sized intrahepatic bile ducts to gastrointestinal hormones. Furthermore, we outline the role of a number of cooperative factors (e.g., nerves, alkaline phosphatase, gastrointestinal hormones, neuropeptides, and bile acids) in the regulation of secretin-stimulated ductal secretion. Finally, we discuss other factors that may also play an important role in the regulation of secretin-stimulated ductal secretion.

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