Colchicine is effective for short-term treatment of slow transit constipation: a double-blind placebo-controlled clinical trial

Taghavi, Seyed Alireza; Shabani, Sanaz; Mehramiri, Asieh; Eshraghian, Ahad; Kazemi, Seyed Mohammad Hasan; Moeini, Mahin; Hosseini-Asl, Mohammad Kazem; Saberifiroozi, Mehdi; Alizade-Naeeni, M; Mostaghni, Amir Ahmad

doi:10.1007/s00384-009-0794-z

Cited by 30 publications

(26 citation statements)

References 40 publications

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“…The mechanism of inducing diarrhea by colchicine is unknown. It has been reported that colchicine increases prostaglandin synthesis, intestinal secretion and gastrointestrial motility 45. It also reduces water and electrolyte absorption in the intestine and increases secretion through a cyclic AMP mediated activity.…”

Section: Prevention and Management Of Constipation In The Elderlymentioning

confidence: 99%

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Update on the management of constipation in the elderly: new treatment options

Rao¹,

Go²

2010

CIA

157

139

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Constipation disproportionately affects older adults, with a prevalences of 50% in community-dwelling elderly and 74% in nursing-home residents. Loss of mobility, medications, underlying diseases, impaired anorectal sensation, and ignoring calls to defecate are as important as dyssynergic defecation or irritable bowel syndrome in causing constipation. Detailed medical history on medications and co-morbid problems, and meticulous digital rectal examination may help identify causes of constipation. Likewise, blood tests and colonoscopy may identify organic causes such as colon cancer. Physiological tests such as colonic transit study with radio-opaque markers or wireless motility capsule, anorectal manometry, and balloon expulsion tests can identify disorders of colonic and anorectal function. However, in the elderly, there is usually more than one mechanism, requiring an individualized but multifactorial treatment approach. The management of constipation continues to evolve. Although osmotic laxatives such as polyethylene glycol remain mainstay, several new agents that target different mechanisms appear promising such as chloride-channel activator (lubiprostone), guanylate cyclase agonist (linaclotide), 5HT4 agonist (prucalopride), and peripherally acting μ-opioid receptor antagonists (alvimopan and methylnaltrexone) for opioid-induced constipation. Biofeedback therapy is efficacious for treating dyssynergic defecation and fecal impaction with soiling. However, data on efficacy and safety of drugs in elderly are limited and urgently needed.

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Section: Prevention and Management Of Constipation In The Elderlymentioning

confidence: 99%

“…In a double-blind, placebo-controlled study of patients with STC (n = 60), colchicine was shown to be effective in lowering Knowles-Eccersly-Scot symptoms (KESS) scores 45. KESS is a valid technique in diagnosing and evaluating symptoms of constipation.…”

Section: Prevention and Management Of Constipation In The Elderlymentioning

confidence: 99%

Update on the management of constipation in the elderly: new treatment options

Rao¹,

Go²

2010

CIA

157

139

View full text Add to dashboard Cite

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“…The duration of constipation prior to inclusion ranged from 6 months to at least 1 year . Other studies used the Rome II or Rome III criteria for functional constipation, implying minimum duration of 12 and 6 months, respectively. Still, other studies used terms like “several years” .…”

Section: Resultsmentioning

confidence: 99%

Searching for a definition for pharmacologically refractory constipation: A systematic review

Soh

Kang

Siah

et al. 2018

J of Gastro and Hepatol

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“…In an 8-week controlled trial in patients with slow transit constipation, colchicine 1 mg daily was superior to placebo in improving a combined constipation symptom severity score [56].…”

Section: Other Agentsmentioning

confidence: 99%