Cold air induced asthma: Relationship to non-specific bronchial responsiveness to methacholine

O'Byrne, Paul M.; Ryan, Gerard; Morris, Marilyn M.; McCormack, DG; Morse, John Lovett; Jones, N.H.; Hargreave, Frederick E.

doi:10.1016/s0091-6749(62)80332-7

Cited by 38 publications

(55 citation statements)

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“…The observed failure of the MSCACh-histamine response correlation to reach statistical significance is in marked contrast to the results of previous studies that compared the responses to a MSCACh with those to pharmacological provocations, and found statistically significant correlations [8][9][10][11][12]. This discrepancy cannot be explained by histamine-methacholine response differences, as these two types of pharmacological provocation produce closely correlated bronchial reactions [26,27].…”

Section: Discussioncontrasting

confidence: 88%

See 1 more Smart Citation

Comparing methods for assessing bronchial responsiveness in children: single step cold air challenge, multiple step cold air challenge, and histamine provocation

Modl

Eber²,

Steinbrugger³

et al. 1995

Eur Respir J

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These results indicate that the stimulus applied and the bronchoconstrictor mechanism activated, and not the challenge protocol, determine the outcome of a cold air challenge. In clinical practice, a brief single step cold air challenge can substitute for a more time-consuming multiple step cold air challenge. As nonpharmacological challenges seem to measure a different type of bronchial responsiveness, neither a single step nor a multiple step cold air challenge can substitute for a pharmacological provocation.

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Section: Discussioncontrasting

confidence: 88%

“…Those studies that compared a MSCACh with a histamine or methacholine provocation demonstrated relatively close correlations [8][9][10][11][12]. Several comparisons between pharmacological challenges and a SSCACh, however, have produced contradictory results.…”

mentioning

confidence: 99%

Comparing methods for assessing bronchial responsiveness in children: single step cold air challenge, multiple step cold air challenge, and histamine provocation

Modl

Eber²,

Steinbrugger³

et al. 1995

Eur Respir J

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“…The final model included effects at lags 1 and 2, that is, delayed effects from up to 2 d prior to the day on which the consultation occurred. Sudden changes in temperature have been implicated in the laboratory setting in the onset of asthma symptoms (Ramsey 1977, Strauss et al 1978, O'Byrne et al 1982, Zawadski et al 1988) but no such effect was a significant predictor in our model. Given the anticipated small overall effect size for the daily weather, there was limited power to detect inter-actions.…”

Section: Discussionmentioning

confidence: 55%

A model of the relationship between consultation behaviour for asthma in a general practice and the weather

Kljakovic¹,

Salmond²

1998

Clim. Res.

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The aim of this study was to build a model showing the relationship between consultations for asthma and the daily weather in a suburban computerised general practice in New Zealand. A retrospective count of the number of asthmatic patients attending the practice on any particular day for a consultation for asthma was compared with the weather variables temperature, rainfall, relative humidity, and wind strength. Quasi-likelihood Poisson regression models were built in steps. There were 3844 consultations for asthma between October 1, 1986 and October 30, 1991. The number varied from 0 to 11 consultations per day (mean 2.1). The annual means were 1.3, 1.9, 2.3, 2.5, and 2.7 consultations per day, respectively. After variables indicating time trends, days of the week, and holiday periods were included in the model, temperature and relative humidity provided the only significant additional explanatory power for variation in consultations.

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“…Si bien la sensibilidad diagnostica del ejercicio mejoro significativamente al usar aire fn'o y seco, 4 de los 14 pacientes (28,6%) no fueron detectados por esta prueba. O'Byrne y cols ban demostrado que la perdida de calor que provoca un 10% de cai'da del VEF] con hiperventilacion isocapnica se correlaciona significativamente con la PC 2 o metacolina 12 . Por lo tanto, sujetos con hiperreactividad bronquial leve necesitan un gran estimulo (gran perdida de calor o agua) para obstruirse.…”

Section: Discusionunclassified

Prueba de Provocación con Ejercicio Respirando Aire Frió y Seco en el Diagnostico de Asma Bronquial en Niños

R²,

B³

et al. 1986

Rev. chil. pediatr.

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Exercise Test in Cold Dry Air for Children Whith AsthmaIn order to study whether freezing of inspired air increases the diagnostic sensitivity of exercise testing in asthmatics, 14 children were exercised in a cycle ergometer in two ocassions, 7 to 10 days apart,breathing room air (22.1 ± 0.6 °C; X + SD) and cold air (-12.4 ± 6 °C). Baseline forced expiratory volume in the first second (VEFi) and heart rate during exercise were similar in both conditions. Pulmonary ventilation was 58 ± 12%of the predicted maximal voluntary ventilation during room air exercise and 61 ± U.% during cold air exercise (p = us). Maximal fall of FEVi was significantly greater after cold air exercise (-16.9 ± 15.2 vs -4.8 ± 7.3%; p 6 . Por ello, la magnitud de la obstruction bronquial esta relacionada con la temperatura y humedad del aire inspirado, condiciones que no son controladas durante las pruebas de provocation con ejercicio respirando aire ambiente. El trabajo descrito a continuation se efectuo con el proposito de estudiar si el ejercicio respirando aire seco y fn'o es mas sensible, como metodo de diagnostico, que el realizado inspirando aire ambiente.

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Cold air induced asthma: Relationship to non-specific bronchial responsiveness to methacholine

Cited by 38 publications

References 0 publications

Comparing methods for assessing bronchial responsiveness in children: single step cold air challenge, multiple step cold air challenge, and histamine provocation

Comparing methods for assessing bronchial responsiveness in children: single step cold air challenge, multiple step cold air challenge, and histamine provocation

A model of the relationship between consultation behaviour for asthma in a general practice and the weather

Prueba de Provocación con Ejercicio Respirando Aire Frió y Seco en el Diagnostico de Asma Bronquial en Niños

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