Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: Results of an open retrospective randomized controlled study in vivo

Isbary, Georg; Stolz, Wilhelm; Shimizu, Tetsuji; Monetti, Roberto A.; Bunk, W.; Schmidt, Hans-Ulrich; Morfill, G. E.; Klämpfl, Tobias G.; Steffes, B.; Thomas, Hubertus M.; Heinlin, J.; Karrer, Sigrid; Landthaler, Míchael; Zimmermann, Julia L.

doi:10.1016/j.cpme.2013.06.001

Cited by 180 publications

(122 citation statements)

References 33 publications

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“…Plasma produces heat, chemical species, and charged particles, and these factors have been applied to the development of medical equipment and sterilizers, and to cancer research [1][2][3][4][5][6]. Many studies have reported the effect of plasma irradiation on bacteria [7,8], viruses [9], and cells [10].…”

Section: Introductionmentioning

confidence: 98%

Gene expression responses of HeLa cells to chemical species generated by an atmospheric plasma flow

Yokoyama

Johkura

Sato

2014

Biochemical and Biophysical Research Communications

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Section: Introductionmentioning

confidence: 98%

Gene expression responses of HeLa cells to chemical species generated by an atmospheric plasma flow

Yokoyama

Johkura

Sato

2014

Biochemical and Biophysical Research Communications

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“…It has been established that, once the plasma treatment course is stopped, wound-healing also slows down [14]. Another in vivo study, using a Micro Plaster alpha device also suggests that wound healing may be accelerated by the CAP treatment [15]. There are studies which provide insights of the mechanism by which the Cap treatment stimulates wound healing.…”

mentioning

confidence: 99%

Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Pandit¹,

Mokkapati²,

Helgadottir³

et al. 2017

Clin Microbiol

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Cold atmospheric plasma (CAP) is increasingly used in medical applications for eradication of bacterial and tumor cells. CAP treatment devices, known as plasma jet pens, produce reactive oxygen and nitrogen species at atmospheric pressure and room temperature. The produced reactive species are concentrated in a small and precisely defined area, allowing for high precision medical treatments. CAP has been demonstrated as very effective against planktonic bacterial cells. Unfortunately, bacterial cells in biofilms are typically aggregated and protected by dense exopolymeric matrix, synthesized and secreted by the bacterial community. The main limitation in using CAP against bacterial biofilms is the thick protective matrix of extracellular polymers that shields bacterial cells within this complex architecture. CAP has also been shown to effectively eradicate tumor cells, but the main current limitation is the susceptibility of the surrounding healthy tissues to higher doses. We have recently demonstrated that vitamin C, a natural food supplement, can be used to destabilize bacterial biofilms and render them more susceptible to the CAP killing treatment. Here we discuss the possible impact that a pre-treatment with vitamin C could have on CAP applications in medicine. Specifically, we argue that vitamin C could enhance the effectiveness of CAP treatments against both the bacterial biofilms and some selected tumors.

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“…The list of possible applications is long, e.g. deposition of wear-resistant SiO 2 thin films [5][6][7], pre-treatment of polymers before printing [8][9][10], sterilization/inactivation of medical tools and treatment of infectious chronic wounds [11,12] to name only some of them.…”

Section: Introductionmentioning

confidence: 99%

Methods of gas purification and effect on the ion composition in an RF atmospheric pressure plasma jet investigated by mass spectrometry

et al. 2016

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The analysis of the ion chemistry of atmospheric pressure plasmas is essential to evaluate ionic reaction pathways during plasma-surface or plasma-analyte interactions. In this contribution, the ion chemistry of a radio-frequency atmospheric pressure plasma jet (μ-APPJ) operated in helium is investigated by mass spectrometry (MS). It is found, that the ion composition is extremely sensitive to impurities such as N 2 , O 2 and H 2 O. Without gas purification, protonated water cluster ions of the form H + (H 2 O) n are dominating downstream the positive ion mass spectrum. However, even after careful feed gas purification to the sub-ppm level using a molecular sieve trap and a liquid nitrogen trap as well as operation of the plasma in a controlled atmosphere, the positive ion mass spectrum is strongly influenced by residual trace gases. The observations support the idea that species with a low ionization energy serve as a major source of electrons in atmospheric pressure helium plasmas. Similarly, the neutral density of atomic nitrogen measured by MS in a He/N 2 mixture is varying up to a factor 3, demonstrating the significant influence of impurities on the neutral species chemistry as well.

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Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: Results of an open retrospective randomized controlled study in vivo

Cited by 180 publications

References 33 publications

Gene expression responses of HeLa cells to chemical species generated by an atmospheric plasma flow

Gene expression responses of HeLa cells to chemical species generated by an atmospheric plasma flow

Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Methods of gas purification and effect on the ion composition in an RF atmospheric pressure plasma jet investigated by mass spectrometry

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