Cold atmospheric plasma, a novel promising anti-cancer treatment modality

Yan, Dayun; Sherman, Jonathan H.

doi:10.18632/oncotarget.13304

Cited by 443 publications

(427 citation statements)

References 162 publications

(349 reference statements)

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“…As previously mentioned, CAP is also used for anticancer therapy [20][21][22][23]. Vitamin C has also been suggested to have adverse effects on cancer cells [28].…”

Section: Combining Vitamin C With Cold Atmospheric Plasmamentioning

confidence: 99%

“…It has been demonstrated that cold plasma can induce necrosis, apoptosis and cell detachment by disrupting certain phases of tumor cell replication [20]. CAP effectiveness has been demonstrated against dozens of tumor cell lines and tumor types in vitro and in vivo, respectively [21]. The unfortunate limitation in the use of CAP against tumors is that a high dose CAP exposure can also harm healthy mammalian cells [20], hence the need for precise micro devices.…”

mentioning

confidence: 99%

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Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Pandit¹,

Mokkapati²,

Helgadottir³

et al. 2017

Clin Microbiol

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Cold atmospheric plasma (CAP) is increasingly used in medical applications for eradication of bacterial and tumor cells. CAP treatment devices, known as plasma jet pens, produce reactive oxygen and nitrogen species at atmospheric pressure and room temperature. The produced reactive species are concentrated in a small and precisely defined area, allowing for high precision medical treatments. CAP has been demonstrated as very effective against planktonic bacterial cells. Unfortunately, bacterial cells in biofilms are typically aggregated and protected by dense exopolymeric matrix, synthesized and secreted by the bacterial community. The main limitation in using CAP against bacterial biofilms is the thick protective matrix of extracellular polymers that shields bacterial cells within this complex architecture. CAP has also been shown to effectively eradicate tumor cells, but the main current limitation is the susceptibility of the surrounding healthy tissues to higher doses. We have recently demonstrated that vitamin C, a natural food supplement, can be used to destabilize bacterial biofilms and render them more susceptible to the CAP killing treatment. Here we discuss the possible impact that a pre-treatment with vitamin C could have on CAP applications in medicine. Specifically, we argue that vitamin C could enhance the effectiveness of CAP treatments against both the bacterial biofilms and some selected tumors.

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“…As previously mentioned, CAP is also used for anticancer therapy [20][21][22][23]. Vitamin C has also been suggested to have adverse effects on cancer cells [28].…”

Section: Combining Vitamin C With Cold Atmospheric Plasmamentioning

confidence: 99%

mentioning

confidence: 99%

Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Pandit¹,

Mokkapati²,

Helgadottir³

et al. 2017

Clin Microbiol

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“…Cold atmospheric plasma (CAP) has been extensively studied for its biomedical use in various fields such as surface decontamination [5], wound healing [6,7], dental treatment [8], allergen destruction [9], HIV virus treatment [10] and among others [11]. In particular, the research of CAP as a potential oncotherapeutic approach has thrived over the past decade and the mechanism is been increasingly understood [12][13][14][15][16]. It is widely reported that CAP deactivated more than 20 types of cancer in vitro by inducing apoptosis [17][18][19], cell cycle arrest [20][21][22], endoplasmic reticulum stress [23,24] and DNA damage [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Triple-Negative Breast Cancer Cells with the Canady Cold Plasma Conversion System: Preliminary Results

Cheng¹,

Rowe²,

Ly³

et al. 2018

Plasma

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Triple-negative breast cancer is a phenotype of breast cancer where the expression level of estrogen, progesterone and human epidermal growth factor receptor 2 (HER2) receptors are low or absent. It is more frequently diagnosed in younger and premenopausal women, among which African and Hispanic have a higher rate. Cold atmospheric plasma has revealed its promising ant-cancer capacity over the past two decades. In this study, we report the first cold plasma jet delivered by the Canady Cold Plasma Conversion Unit and characterization of its electric and thermal parameters. The unit effectively reduced the viability of triple-negative breast cancer up to 80% without thermal damage, providing a starting point for future clinical trials.

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“…The observed beneficial effects in wound healing [4][5][6] and cancer [7][8][9] have significantly spurred research efforts and novel findings in recent years. Promising in vitro research investigations are an ethical and scientific necessity for translation of plasma applications to in vivo models and eventually to humans.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Floating-Electrode DBD and kINPen Jet: Plasma Parameters to Achieve Similar Growth Reduction in Colon Cancer Cells Under Standardized Conditions

Bekeschus

Lin

Fridman

et al. 2017

Plasma Chem Plasma Process

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A comparative study of two plasma sources (floating-electrode dielectric barrier discharge, DBD, Drexel University; atmospheric pressure argon plasma jet, kINPen, INP Greifswald) on cancer cell toxicity was performed. Cell culture protocols, cytotoxicity assays, and procedures for assessment of hydrogen peroxide (H 2 O 2 ) were standardized between both labs. The inhibitory concentration 50 (IC50) and its corresponding H 2 O 2 deposition was determined for both devices. For the DBD, IC50 and H 2 O 2 generation were largely dependent on the total energy input but not pulsing frequency, treatment time, or total number of cells. DBD cytotoxicity could not be replicated by addition of H 2 O 2 alone and was inhibited by larger amounts of liquid present during the treatment. Jet plasma toxicity depended on peroxide generation as well as total cell number and amount of liquid. Thus, the amount of liquid present during plasma treatment in vitro is key in attenuating short-lived species or other physical effects from plasmas. These in vitro results suggest a role of liquids in or on tissues during plasma treatment in a clinical setting. Additionally, we provide a platform for correlation between different plasma sources for a predefined cellular response.

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Cold atmospheric plasma, a novel promising anti-cancer treatment modality

Cited by 443 publications

References 162 publications

Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Treatment of Triple-Negative Breast Cancer Cells with the Canady Cold Plasma Conversion System: Preliminary Results

A Comparison of Floating-Electrode DBD and kINPen Jet: Plasma Parameters to Achieve Similar Growth Reduction in Colon Cancer Cells Under Standardized Conditions

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