Cold atmospheric plasma applications in dermatology: A systematic review

Abstract

Cold atmospheric plasma (CAP) applications can potentially lead to effective therapy for numerous skin diseases. Our aim is to systematically review the available data and map the use of CAP in dermatology. PubMed, Embase and Web of science were explored before 2020 for studies regarding the use of CAP in dermatology. A total of 166 studies were finally included. 74.1% of these studies used indirect CAP sources. Most studies used plasma jet (67.5%). Argon was the mostly used working gas (48.2%). Plasma application itself could be direct (89.2%) and indirect (16.3%). The proportion of studies with in vivo results remained 57.2%, of which most concerned direct plasma treatment (97.9%). Analyses performed indicate that CAP has been beneficial in many skin disorders. While, most CAP applications were focused on wound healing and melanoma treatment. This study provides a brief overview of CAP sources and relative medical applications in dermatology.

Plasma Dermatology: Skin Therapy Using Cold Atmospheric Plasma

“…Since then, several reviews have been published on this topic, but each with pros and cons (19)(20)(21)(22)(23)(24). Some are oversimplified in terms of disease spectrum, others failed to balance the clinical findings and scientific interpretation.…”

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

“…A systematic review of CAP applications in dermatology and especially of wound healing analyzing 166 studies also comes to the conclusion that CAP treatment acts beneficially. The study emphasizes that CAP can act in concert with other drugs and optimize percutaneous drug delivery [68].…”

Non‐invasive physical plasma (NIPP) treatment of a hedgehog with head injury: A novel therapy in veterinary medicine

“…Non‐invasive physical plasma (NIPP) therapy was established more than 20 years ago for applications in human medicine. Since 2010, results from in vitro studies were confirmed by clinical trials, which revealed that NIPP is effective for the treatment of wounds 2–10 . In veterinary medicine, however, this therapeutic approach is still far from being established.…”

“…Since 2010, results from in vitro studies were confirmed by clinical trials, which revealed that NIPP is effective for the treatment of wounds. [2][3][4][5][6][7][8][9][10] In veterinary medicine, however, this therapeutic approach is still far from being established. NIPP represents an approach that is based on highly energised gas transferring energy to molecules of the surrounding atmosphere.…”