Cold atmospheric plasma delivery for biomedical applications

Chen, Zhitong; Chen, Guojun; Obenchain, Richard; Zhang, Rui; Bai, Fan; Fang, Tianxu; Wang, Hanwen; Lu, Yunhu; Wirz, Richard E.; Gu, Zhen

doi:10.1016/j.mattod.2022.03.001

Cited by 63 publications

(45 citation statements)

References 348 publications

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“…American scientist Irving Langmuir initially characterized plasma as one of the four fundamental states of matter in 1922 [ 116 ]. Plasmas are gases that have been totally or partially ionized.…”

Section: Virus Deactivation By Nonthermal Atmospheric Plasma (Ntap)mentioning

confidence: 99%

“…Because NTAP is applied at room temperature, it is suitable for treating a wide range of biological materials, including solids, liquids, and aerosols. There are numerous applications for the two types of NTP, low pressure and atmospheric pressure [ 116 , 124 , 125 , 126 , 127 , 128 , 129 , 130 ]. Plasma medicine is a developing field that is attracting researchers from various disciplines, such as engineering, plasma physics, biology, and medicine [ 131 ].…”

Section: Virus Deactivation By Nonthermal Atmospheric Plasma (Ntap)mentioning

confidence: 99%

“…NTAP has a significant impact on water pH and conductivity because they are closely related to ion generation in the aqueous phase. When NTAP was applied to the water, nitrite species formed, lowering the pH and increasing conductivity due to ionic species [ 116 ]. When it came to the inactivation of viruses inside water, salinity and temperature also had a substantial role [ 117 ].…”

Section: Virus Deactivation By Nonthermal Atmospheric Plasma (Ntap)mentioning

confidence: 99%

“…(c) plasma delivery strategies, which include direct application, plasma-activated media, device-assisted delivery, and a combination of these. Reproduced with permission from [116]. Copyright 2022, Elsevier.…”

Section: The Introduction Of Ntapmentioning

confidence: 99%

See 3 more Smart Citations

Review of Developments in Combating COVID-19 by Vaccines, Inhibitors, Radiations, and Nonthermal Plasma

Han

Mumtaz

Srinivasan

et al. 2022

CIMB

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Global society has been highly pressured by the COVID-19 pandemic, which has exposed vulnerabilities in supply chains for disinfection products, personal protective equipment, and medical resources worldwide. It is critically necessary to find effective treatments and medications for these viral infections. This review summarizes and emphasizes critical features of recent breakthroughs in vaccines, inhibitors, radiations, and innovative nonthermal atmospheric plasma (NTAP) technologies to inactivate COVID-19. NTAP has emerged as an effective, efficient, and safe method of viral inactivation. NTAP can be used to inactivate viruses in an environmentally friendly manner, as well as activate animal and plant viruses in a variety of matrices. Researchers and engineers desire to help the medical world deal with the ongoing COVID-19 epidemic by establishing techniques that make use of widely available NTAP technologies. NTAP technology is not dependent on viral strain, and it does not necessitate months or years of research to develop specific vaccines for each novel or arising viral disease. We believe the NTAP is a highly promising technique for combating COVID-19 and other viruses. Thus, NTAP technology could be a significant breakthrough in the near future in assisting humans in combating COVID-19 infections. We hope that this review provides a platform for readers to examine the progress made in the fight against COVID-19 through the use of vaccines, inhibitors, radiation, and NTAP.

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Section: Virus Deactivation By Nonthermal Atmospheric Plasma (Ntap)mentioning

confidence: 99%

Section: Virus Deactivation By Nonthermal Atmospheric Plasma (Ntap)mentioning

confidence: 99%

Section: Virus Deactivation By Nonthermal Atmospheric Plasma (Ntap)mentioning

confidence: 99%

Section: The Introduction Of Ntapmentioning

confidence: 99%

See 2 more Smart Citations

Review of Developments in Combating COVID-19 by Vaccines, Inhibitors, Radiations, and Nonthermal Plasma

Han

Mumtaz

Srinivasan

et al. 2022

CIMB

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“…Due to their intrinsic configuration, dielectric barrier discharges (DBD) are often used to build plasma jet reactors for endoscopy. The dielectric barrier limits the current flowing through the plasma and allows for a homogeneous discharge at room temperature, suitable for heat-sensitive tissues [22], [23]. In this context, a better understanding of DBD plasma reactor behavior and how to predict that behavior is necessary to optimize, monitor, and control DBD plasma medical devices [24].…”

Section: Introductionmentioning

confidence: 99%

Analysis of a nano-pulsed DBD Plasma jet for endoscopy and impact of excitation parameters

Bastin¹,

Thulliez²,

Delchambre³

et al. 2022

J. Phys. D: Appl. Phys.

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Cold atmospheric plasma induces various dose-dependent effects on living cells, from proliferation to necrosis. These effects are of interest in the field of therapeutic flexible endoscopy, although implementing an effective plasma delivery system represents a technical challenge. This work studies the impact of critical parameters on plume intensity, delivered reactive species, and current administered to the target for the use of plasma in endoscopy. A two-meter-long dielectric barrier discharge plasma jet was studied upon nano-pulsed high voltage excitation to increase plasma reactivity. The peak voltage, gas gap, pulse repetition frequency, and pulse width were varied while the power dissipated by the system and the optical emissions (with imaging and spectrometry) were measured. Two configurations were compared: the first one with the plume exiting freely in air, and the second one with the plume impinging an electrical equivalent of the human body. Finally, the current flowing through the capillary was measured at regular intervals along the tube with a Rogowski coil. Results show that i) a conductive target increases the ratio of reactive species produced over the dissipated power, ii) increasing the pulse repetition frequency does not improve the reactive species production per pulse (e.g., through a synergetic, memory effect), iii) increasing the pulse width does not influence reactive species production but increases the dissipated power, and iv) current linearly leaks through the tube walls, and leaks are lower with nano-pulsed compared to sinusoidal excitation. Reactance and capacitance values of the system are analyzed based on the electrical equivalent circuit approach. Finally, displacement and discharge currents are discussed to bring power dissipation mechanisms to light and compare them between configurations.The conclusions drawn are important for the future design of safe and effective endoscopic plasma devices.

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Injectable Plasma‐Treated Alginate Hydrogel for Oxidative Stress Delivery to Induce Immunogenic Cell Death in Osteosarcoma

Živanić,

Espona‐Noguera,

Verswyvel

et al. 2023

Adv Funct Materials

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Cold atmospheric plasma (CAP) is a source of cell‐damaging oxidant molecules that may be used as low‐cost cancer treatment with minimal side effects. Liquids treated with cold plasma and enriched with oxidants are a modality for non‐invasive treatment of internal tumors with cold plasma via injection. However, liquids are easily diluted with body fluids which impedes high and localized delivery of oxidants to the target. As an alternative, plasma‐treated hydrogels (PTH) emerge as vehicles for the precise delivery of oxidants. This study reports an optimal protocol for the preparation of injectable alginate PTH that ensures the preservation of plasma‐generated oxidants. The generation, storage, and release of oxidants from the PTH are assessed. The efficacy of the alginate PTH in cancer treatment is demonstrated in the context of cancer cell cytotoxicity and immunogenicity–release of danger signals and phagocytosis by immature dendritic cells, up to now unexplored for PTH. These are shown in osteosarcoma, a hard‐to‐treat cancer. The study aims to consolidate PTH as a novel cold plasma treatment modality for non‐invasive or postoperative tumor treatment. The results offer a rationale for further exploration of alginate‐based PTHs as a versatile platform in biomedical engineering.

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Cold atmospheric plasma delivery for biomedical applications

Cited by 63 publications

References 348 publications

Review of Developments in Combating COVID-19 by Vaccines, Inhibitors, Radiations, and Nonthermal Plasma

Review of Developments in Combating COVID-19 by Vaccines, Inhibitors, Radiations, and Nonthermal Plasma

Analysis of a nano-pulsed DBD Plasma jet for endoscopy and impact of excitation parameters

Injectable Plasma‐Treated Alginate Hydrogel for Oxidative Stress Delivery to Induce Immunogenic Cell Death in Osteosarcoma

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