Cold atmospheric plasma for the ablative treatment of neuroblastoma

Effect of Cold Atmospheric Plasma on Ehrlich Carcinoma

“…This indicates that there is positive effect of cold plasma jet on both tumor growth and survival period of the experimental animals (5,19) . …”

Biophysical Effects of Cold Atmospheric Plasma on Glial Tumor Cells

“…2.5b, c). Using a plasma jet device other groups were able to show apoptosis by Annexin V staining and TUNEL in neuroblastoma [22], in melanoma cells [23] and pancreatic cells [24]. The DNA damage markers yH2AX and cleaved PARP1 were only present 48 and 72 h, respectively, after CAP treatment using the SMD device (Fig.…”

“…Since then, several developed CAP sources have been demonstrated to inactivate bacteria, fungi, viruses, and spores in a dose-dependent manner [14,[19][20][21][22]. First therapeutic approaches in plasma medicine were established in dermatology [23,24] and wound disinfection [2,25].…”

Cold atmospheric pressure plasma for treatment of chronic wounds: drug or medical device?

“…[9][10][11][12][13] First reports on the use of argon plasma for tumor removal date back to 1989 14 , followed by successful ablation of nonneoplastic Barrett's mucosa 15 and other neoplastic diseases. [16][17][18][19][20][21] A plasma-activated medium has even been claimed to exert anti-tumor effects. 22,23 Results of in-vitro, 24 in-vivo [24][25][26][27][28] and initial clinical studies on chronic wounds of domestic animals 29,30 and humans [31][32][33][34][35] indicate that CAP may be a promising alternative to conventional treatment options, based on the following biological premises:…”