Cold Atmospheric Plasma Suppressed MM In Vivo Engraftment by Increasing ROS and Inhibiting the Notch Signaling Pathway

Miao, Qi; Zhao, Xinyi; Fan, Runze; Zhang, Xinying; Peng, Sansan; Xu, Dehui; Yang, Yanjie

doi:10.3390/molecules27185832

Cited by 6 publications

(2 citation statements)

References 54 publications

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“…In addition, ROS could also trigger oxidative stress to promote cell death [44]. Studies had con rmed that LTP can inhibit multiple myeloma and prolong survival time by inducing ROS production and inhibiting Notch signaling pathway [45]. In this experiment, it was found that the active oxygen content increased with the treatment time, but the cell viability decreased, which was consistent with the previous study.…”

Section: Kegg Pathway Enrichment Analysis Of Degssupporting

confidence: 90%

Effect of low temperature plasma on the transcriptome of breast cancer cells

Liu,

Yan,

Liu

et al. 2024

Preprint

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Breast cancer is one of the most commonly diagnosed cancers in women, and due to the limitations of its therapeutic methods, new therapeutic method need to be developed. More and more evidences had shown the potential of low-temperature plasma (LTP) in cancer treatment. In this study, we investigated the inhibitory effect of LTP on the in vitro toxicity of breast cancer cells through the MTT assay, extracellular reactive oxygen species (ROS), and transcriptomics analysis. The results showed that under a certain treatment time, the cell viability was gradually decreased, and the extracellular ROS was gradually increased. In addition, the results of transcriptomics analysis showed that 1272 DEGs, 1573 DEGs, and 1272 DEGs were obtained in the 15s, 30s, and 45s treatment groups, respectively. DEGs were involved in MAPK signaling pathway, Fox O signaling pathway, Wnt signaling pathway, TGF-beta signaling pathway, chemical carcinogenesis-reactive oxygen species and mTOR Signaling pathway. In summary, our data suggested that LTP inhibited cell viability while inducing the activation of differentially expressed genes, representing a potential new therapy for breast cancer.

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Section: Kegg Pathway Enrichment Analysis Of Degssupporting

confidence: 90%

Effect of low temperature plasma on the transcriptome of breast cancer cells

Liu,

Yan,

Liu

et al. 2024

Preprint

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“…Thiyagarajan et al, 2013; 2021 Plasma jet, Air Xu et al, 2019b Plasma jet, Argon Ji et al, 2020; Guo et al, 2021; Guo et al, 2022 Multiple myeloma Plasma jet, HeliumXu et al, 2016Xu et al, , 2018aXu et al, , 2018bXu et al, , 2019aQi et al, 2022b …”

mentioning

confidence: 99%

Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy

Dai,

Wu,

et al. 2023

Biomol Ther (Seoul)

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Cold atmospheric plasma (CAP), a redox modulation tool, is capable of inhibiting a wide spectrum of cancers and has thus been proposed as an emerging onco-therapy. However, with incremental successes consecutively reported on the anticancer efficacy of CAP, no consensus has been made on the types of tumours sensitive to CAP due to the different intrinsic characteristics of the cells and the heterogeneous design of CAP devices and their parameter configurations. These factors have substantially hindered the clinical use of CAP as an oncotherapy. It is thus imperative to clarify the tumour types responsive to CAP, the experimental models available for CAP-associated investigations, CAP administration strategies and the mechanisms by which CAP exerts its anticancer effects with the aim of identifying important yet less studied areas to accelerate the process of translating CAP into clinical use and fostering the field of plasma oncology.

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Perfusable Plasma‐Activated Saline for Oxidative Stress Delivery to Induce Tumor Cell Apoptosis in Nonmuscle‐Invasive Bladder Cancer

Zhu,

Xu,

et al. 2024

Plasma Processes & Polymers

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Nonmuscle‐invasive bladder cancer (NMIBC) is a common urologic malignancy. Currently, conventional postoperative perfusion therapy for NMIBC still has high side effects and recurrence rates. Cold atmospheric plasma is a fledgling reactive oxygen species (ROS)–based therapeutic technique for cancer treatment. In this study, we examined the feasibility of plasma‐activated saline (PAS) perfusion for treating NMIBC. The results show that underwater bubble plasma can generate abundant ROS in PAS. In vitro studies revealed that PAS could trigger apoptosis in bladder cancer T24 cells by activating the ROS‐mediated caspase‐3 cascade reaction. In vivo tests revealed that intravesical PAS perfusion effectively inhibited nonmuscle‐invasive T24 tumor growth without significant side effects. Therefore, our results suggest that intravesical PAS perfusion may be a novel treatment option for NMIBC.

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Cold Atmospheric Plasma Suppressed MM In Vivo Engraftment by Increasing ROS and Inhibiting the Notch Signaling Pathway

Cited by 6 publications

References 54 publications

Effect of low temperature plasma on the transcriptome of breast cancer cells

Effect of low temperature plasma on the transcriptome of breast cancer cells

Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy

Perfusable Plasma‐Activated Saline for Oxidative Stress Delivery to Induce Tumor Cell Apoptosis in Nonmuscle‐Invasive Bladder Cancer

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