Cold atmospheric plasma treated 3D printed polylactic acid film; application in thin film solid phase microextraction of anticancer drugs

Recent Developments in the Use of Plasma in Medical Applications

“…A simple plasma-polymerized allylamine layer was found to improve the cytocompatibility of a three-dimensional (3D)-printed vascular stent [60]. There is an increasing body of emerging work with respect to plasma coatings being used to modify 3D-printed and electrospun devices [61], as shown schematically in Figure 3. Though there are numerous reports of plasma being used to activate or oxidize 3D-printed scaffolds [62], until recently, there have been very few reports of active plasma coatings of such scaffolds [63,64].…”

“…Though there are numerous reports of plasma being used to activate or oxidize 3D-printed scaffolds [62], until recently, there have been very few reports of active plasma coatings of such scaffolds [63,64]. The low temperature of the plasma process and ability to penetrate into 3D substrates without risking pores being blocked allows for a positive synergy between the additive manufacturing and plasma processing, and recent research has reported progress in applications as diverse as ion implantation [65], drug monitoring [61], antimicrobial coating [22] and cell growth [66,67]. Asadian et al [68] reported on the effects of plasma-deposited acrylic acid and allylamine layers to direct cell differentiation on polycaprolactone electrospun meshes.…”