Cold Atmospheric Pressure Plasma Technology for Biomedical Application

Khanikar, Rakesh Ruchel; Bailung, Heremba

doi:10.5772/intechopen.98895

Cited by 9 publications

(10 citation statements)

References 49 publications

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“…CAP therapy is an innovative approach in the biomedical field and it has remarkable merits including tissue regeneration, cell proliferation, and antiseptic effects [ 5 7 11 20 ]. In addition to its non-invasive and practical nature, CAP has made important advances as a versatile tool in human medicine.…”

Section: Discussionmentioning

confidence: 99%

Application of cold atmospheric microwave plasma as an adjunct therapy for wound healing in dogs and cats

et al. 2023

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Background Cold atmospheric plasma is a novel innovative approach for wound care, and it is currently underrepresented in veterinary medicine. Objectives To investigate the efficacy and safety of using cold atmospheric microwave plasma (CAMP) as an adjunct therapy for wound healing in dogs and cats. Methods Wound healing outcomes were retrospectively analyzed using clinical records of client-owned dogs and cats who were first managed through standard wound care alone (pre-CAMP period) and subsequently via CAMP therapy (CAMP period). The degree of wound healing was estimated based on wound size and a modified wound scoring system. Results Of the 27 acute and chronic wounds included in the analysis, 81.48% showed complete healing after the administration of CAMP as an adjunct therapy to standard care. Most wounds achieved complete healing in < 5 weeks. Compared with the pre-CAMP period, the rate of wound healing significantly increased every week in the CAMP period in terms of in wound size (first week, p < 0.001; second week, p = 0.012; third week, p < 0.001) and wound score (first week, p < 0.001; second week, p < 0.001; third week, p = 0.001). No adverse events were noted except for mild discomfort and transient erythema. Conclusions CAMP is a well-tolerated therapeutic option with immense potential to support the treatment of wounds of diverse etiology in small animal practice. Further research is warranted to establish specific criteria for CAMP treatment according to wound characteristics.

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Section: Discussionmentioning

confidence: 99%

Application of cold atmospheric microwave plasma as an adjunct therapy for wound healing in dogs and cats

et al. 2023

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“…A modified four-jet CAPP device constructed in-house with cylindrical dielectric barrier plasma jet configuration [51,62], was used to treat the peptide samples as illustrated in figure 1(a). It consists of four di-electric tubes which are made up of glass.…”

Section: Capp Source and Peptide Treatmentmentioning

confidence: 99%

Cold atmospheric pressure plasma assisted rapid assembly of peptide-based structures: a molecular scaffold to form supramolecular architectures

Basumatary,

Gaikhe,

Radhakrishnanand

et al. 2024

J. Phys. D: Appl. Phys.

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The use of Cold Atmospheric Pressure Plasma (CAPP) technology in the production of peptide-based materials has shown great potential in modern technology. Herein, two aggregation-prone oligopeptides, GNNQQNY and KLVFFA, were subjected to CAPP treatment to form supramolecular assemblies/aggregates. Through peptide engineering and biophysical techniques, the effect of CAPP-generated reactive oxygen and nitrogen species (ROS/RNS) on the oligopeptides were investigated for different treatment times revealing that the formation of these aggregates were primarily driven by electrostatic interactions without any chemical modifications. Field Emission-Scanning Electron Microscopy (FE-SEM) and Thioflavin T (ThT) binding assay confirmed the presence of distinct β-strands, particularly in the aggregates of the KLVFFA peptide upon CAPP irradiation. The combination of CAPP technology with peptide self-assembly process and the characterization techniques employed in this study holds promise for the development of such peptide supramolecular structures based on the specific amino acid sequences.

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“…); and ( 2 ) ions, electrons, and reactive chemical species. The technical possibility of generating physical plasma at low temperatures in an atmospheric environment opens new chances to use this so-called cold atmospheric plasma (CAP) for medical therapies ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Adjuvant composite cold atmospheric plasma therapy increases antitumoral effect of doxorubicin hydrochloride

Kniazeva¹,

Tzerkovsky

Baysal

et al. 2023

Front. Oncol.

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IntroductionCancer is a global health concern, with a significant impact on mortality rates. Despite advancements in targeted antitumor drugs, the development of new therapies remains challenging due to high costs and tumor resistance. The exploration of novel treatment approaches, such as combined chemotherapy, holds promise for improving the effectiveness of existing antitumor agents. Cold atmospheric plasma has demonstrated antineoplastic effects in preclinical studies, but its potential in combination with specific ions for lymphosarcoma treatment has not been investigated.MethodsAn in vivo study was conducted using a Pliss lymphosarcoma rat model to evaluate the antitumor effects of composite cold plasma and controlled ionic therapy. Groups of rats were exposed to composite cold plasma for 3, 7, and 14 days, while the control group received no treatment. Additionally, a combination of chemotherapy with cold plasma therapy was assessed, with doxorubicin hydrochloride administered at a dosage of 5 mg/kg. PERENIO IONIC SHIELD™ emitted a controlled ionic formula during the treatment period.ResultsThe in vivo study demonstrated tumor growth inhibition in groups exposed to composite cold plasma for 3, 7, and 14 days compared to the control group. Furthermore, combining chemotherapy with cold plasma therapy resulted in a threefold reduction in tumor volume. The most significant antitumor effects were observed when doxorubicin hydrochloride at a dosage of 5 mg/kg was combined with 14 days of PERENIO IONIC SHIELD™ ionic therapy.DiscussionThe use of composite cold plasma therapy, in conjunction with a controlled ionic formula emitted by PERENIO IONIC SHIELD™, in the complex treatment of lymphosarcoma in rats showed promising antitumor effects. The combination therapy, particularly when combined with doxorubicin hydrochloride, demonstrated enhanced efficacy. These findings suggest the potential for utilizing cold atmospheric plasma and controlled ions as an adjunctive treatment approach in lymphosarcoma therapy. Further research is warranted to explore the mechanisms underlying these effects and to evaluate the safety and efficacy in human clinical trials.

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Cold Atmospheric Pressure Plasma Technology for Biomedical Application

Cited by 9 publications

References 49 publications

Application of cold atmospheric microwave plasma as an adjunct therapy for wound healing in dogs and cats

Application of cold atmospheric microwave plasma as an adjunct therapy for wound healing in dogs and cats

Cold atmospheric pressure plasma assisted rapid assembly of peptide-based structures: a molecular scaffold to form supramolecular architectures

Adjuvant composite cold atmospheric plasma therapy increases antitumoral effect of doxorubicin hydrochloride

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