Cold Atmospheric Pressure Plasmas (CAPs) for Skin Wound Healing

Xiong, Zilan

doi:10.5772/intechopen.76093

Cited by 15 publications

(12 citation statements)

References 99 publications

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“…Significantly, this approach may also be applicable to wound care. By using a cold atmospheric pressure plasma device to deposit biologics, it may be possible to combine the benefits of plasma medicine [39][40][41][42][43] with targeted local delivery of biologic therapeutics at a wound site [36]. Such an approach could allow for significant benefits across a range of clinical conditions.…”

Section: Discussionmentioning

confidence: 99%

Deposition of Cell Culture Coatings Using a Cold Plasma Deposition Method

O'Sullivan

McArdle

et al. 2020

Applied Sciences

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Collagen coatings were applied onto polystyrene microplates using a cold atmospheric pressure plasma process. The coatings were compared to standard wet chemical collagen thin films using microscopy, surface energy, infra-red spectroscopy, electrophoresis, and cell culture techniques. Thin films were also deposited on gold electrodes using both coating methods and their structural and barrier properties probed using cyclic voltammetry. While the wet chemical technique produced a thicker deposit, both films appear equivalent in terms of coverage, porosity, structure, and chemistry. Significantly, the cold plasma method preserves both the primary and secondary structure of the protein and this results in high biocompatibility and cell activity that is at least equivalent to the standard wet chemical technique. The significance of these results is discussed in relation to the benefits of a single step plasma coating in comparison to the traditional multi-step aseptic coating technique.

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Section: Discussionmentioning

confidence: 99%

Deposition of Cell Culture Coatings Using a Cold Plasma Deposition Method

O'Sullivan

McArdle

et al. 2020

Applied Sciences

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“…The primary intention of CAP use was to provide a modern form of wound disinfection. However, CAP treatment has already proved beneficial in wound healing due to increased cutaneous microcirculation, monocyte stimulation, keratinocyte and fibroblasts proliferation, and cell migration [26,27]. Of these, the keratinocytes and fibroblasts are especially important in the later wound-healing phases [26].…”

Section: Use Of Cold Plasma For Treatment Of Chronic and Acute Woundsmentioning

confidence: 99%

“…Moreover, all cells can act differently in in vitro conditions and they can respond differently to the cells in living organism tissues. This highlights the possibility of different responses to CAP devices in those cell types and also under in vitro and in vivo conditions [26]. However, it is generally presumed that low dose plasma treatment stimulates cell viability and enhances proliferation, differentiation, and migration, while high doses should induce cell apoptosis [26].…”

Section: Introductionmentioning

confidence: 99%

Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

Braný

Dvorska

Halašová

et al. 2020

IJMS

238

138

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Cold atmospheric plasma use in clinical studies is mainly limited to the treatment of chronic wounds, but its application in a wide range of medical fields is now the goal of many analyses. It is therefore likely that its application spectrum will be expanded in the future. Cold atmospheric plasma has been shown to reduce microbial load without any known significant negative effects on healthy tissues, and this should enhance its possible application to any microbial infection site. It has also been shown to have anti-tumour effects. In addition, it acts proliferatively on stem cells and other cultivated cells, and the highly increased nitric oxide levels have a very important effect on this proliferation. Cold atmospheric plasma use may also have a beneficial effect on immunotherapy in cancer patients. Finally, it is possible that the use of plasma devices will not remain limited to surface structures, because current endeavours to develop sufficiently miniature microplasma devices could very likely lead to its application in subcutaneous and internal structures. This study summarises the available literature on cold plasma action mechanisms and analyses of its current in vivo and in vitro use, primarily in the fields of regenerative and dental medicine and oncology.

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“…Whether the application of CAP will initiate apoptotic or other processes depends to a large extent on the duration of exposure, distance, dose and duration of exposure and gas content. Low dose CAP treatment and an exposure less than 60 s leads to increased proliferation and wound healing, but a bigger dose and longer exposure time lead to controlled cell death [12,[234][235][236]. Finally, known data indicates that CAP also seems to have a strong apoptotic effect on cancer cells resistant to current treatments.…”

Section: Cap and Apoptosismentioning

confidence: 99%

Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology

Žúbor

Wang

Líšková

et al. 2020

IJMS

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Vulvar cancer (VC) is a specific form of malignancy accounting for 5–6% of all gynaecologic malignancies. Although VC occurs most commonly in women after 60 years of age, disease incidence has risen progressively in premenopausal women in recent decades. VC demonstrates particular features requiring well-adapted therapeutic approaches to avoid potential treatment-related complications. Significant improvements in disease-free survival and overall survival rates for patients diagnosed with post-stage I disease have been achieved by implementing a combination therapy consisting of radical surgical resection, systemic chemotherapy and/or radiotherapy. Achieving local control remains challenging. However, mostly due to specific anatomical conditions, the need for comprehensive surgical reconstruction and frequent post-operative healing complications. Novel therapeutic tools better adapted to VC particularities are essential for improving individual outcomes. To this end, cold atmospheric plasma (CAP) treatment is a promising option for VC, and is particularly appropriate for the local treatment of dysplastic lesions, early intraepithelial cancer, and invasive tumours. In addition, CAP also helps reduce inflammatory complications and improve wound healing. The application of CAP may realise either directly or indirectly utilising nanoparticle technologies. CAP has demonstrated remarkable treatment benefits for several malignant conditions, and has created new medical fields, such as “plasma medicine” and “plasma oncology”. This article highlights the benefits of CAP for the treatment of VC, VC pre-stages, and postsurgical wound complications. There has not yet been a published report of CAP on vulvar cancer cells, and so this review summarises the progress made in gynaecological oncology and in other cancers, and promotes an important, understudied area for future research. The paradigm shift from reactive to predictive, preventive and personalised medical approaches in overall VC management is also considered.

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Cold Atmospheric Pressure Plasmas (CAPs) for Skin Wound Healing

Cited by 15 publications

References 99 publications

Deposition of Cell Culture Coatings Using a Cold Plasma Deposition Method

Deposition of Cell Culture Coatings Using a Cold Plasma Deposition Method

Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology

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