Cold Exposure–induced Alterations in the Brain Peptidome and Gut Microbiome Are Linked to Energy Homeostasis in Mice

Wang, Xue; Wang, Qianqian; Zhao, Mingxin; Xu, Ying; Fu, Bin; Zhang, Li; Wu, Shuai; Yang, Danfeng; Jia, Chenxi

doi:10.1016/j.mcpro.2023.100525

Cited by 3 publications

(3 citation statements)

References 57 publications

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“…56 SCFAs act on their receptors to regulate the release of GLP-1, while the nervous system can regulate the secretion of various hormones in response to exogenous stimuli. 66,69 Therefore, we measured the hormone content in plasma and, as expected, cold temperatures induced a decrease in the GLP-1 level and an increase in the T3 level. Notably, hormone levels in the CH group were closer to those in the CON group, which preliminarily revealed the positive effect of a high-fat diet on host metabolic homeostasis in cold temperatures.…”

Section: Discussionmentioning

confidence: 60%

“…These actions are dependent on metabolites (such as SCFAs, secondary bile acids, and indole derivatives), and also affect the secretion of neurotransmitters. 27,38,39,66,67 Therefore, in addition to SCFAs, we measured the changes in metabolites and hormones in blood. The positive effects of SCFAs, especially butyrate, on gut immunity and inflammation have been widely demonstrated.…”

Section: Papermentioning

confidence: 99%

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Dietary-fat supplementation alleviates cold temperature-induced metabolic dysbiosis and barrier impairment by remodeling gut microbiota

He,

Ding,

Feng

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 60%

Section: Papermentioning

confidence: 99%

Dietary-fat supplementation alleviates cold temperature-induced metabolic dysbiosis and barrier impairment by remodeling gut microbiota

He,

Ding,

Feng

et al. 2024

Food Funct.

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show abstract

“…Neuropeptides are important signaling factors in the nervous system and are involved in various physiological and behavioral regulatory processes. − Many reports have shown that alterations in neuropeptide levels are closely related to the pathological characteristics of AD. − Moreover, some neuropeptides were codistributed with Aβ in the brains of patients with AD. , Polypeptides can bind to Aβ and alter its aggregation dynamics, affect the formation of Aβ oligomers and fibrils, and protect neural cells. , In addition, amyloid deposition plaques composed of Aβ and metal ions have been found via autopsy . Metal ions, such as Cu(II), can stabilize the structured Aβ oligomer and thus affect its neurotoxicity. − Most recently, Han et al reported that the conformation and function of somatostatin were altered by binding to metal-bound or metal-free Aβ species .…”

Section: Introductionmentioning

confidence: 99%

Native Mass Spectrometry-Centric Approaches Revealed That Neuropeptides Frequently Interact with Amyloid-β

Wang,

Wang

et al. 2024

ACS Chem. Neurosci.

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Amyloid-β (Aβ) aggregates are recognized as initiators of Alzheimer’s disease, and their interaction with the nervous system contributes to the progression of neurodegeneration. Herein, we investigated the frequency at which neuropeptides interact with Aβ and affect the aggregation kinetics and cytotoxicity of Aβ. To this end, we established a native mass spectrometry (MS)-centric workflow for screening Aβ-interacting neuropeptides, and six out of 12 neuropeptides formed noncovalent complexes with Aβ species in the MS gas phase. Thioflavin-T fluorescence assays and gel separation indicated that leptin and cerebellin decreased Aβ aggregation, whereas kisspeptin increased this process. In addition, leptin and cerebellin attenuated Aβ-induced cytotoxicity, which was independent of the influence of metal ions. Leptin can chelate copper from copper-bound Aβ species, reducing the cytotoxicity caused by the aggregation of Aβ and metal ion complexes. Overall, our study demonstrated that neuropeptides frequently interact with Aβ and revealed that leptin and cerebellin are potential inhibitors of Aβ aggregation, providing great insight into understanding the molecular mechanism of Aβ interacting with the nervous system and facilitating drug development.

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The Role of Insulin Within the Socio-Psycho-Biological Framework in Type 2 Diabetes—A Perspective from Psychoneuroimmunology

Wevers,

San Roman-Mata,

Navarro-Ledesma

et al. 2024

Biomedicines

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The interplay between socio-psychological factors and biological systems is pivotal in defining human health and disease, particularly in chronic non-communicable diseases. Recent advancements in psychoneuroimmunology and mitochondrial psychobiology have emphasized the significance of psychological factors as critical determinants of disease onset, progression, recurrence, and severity. These insights align with evolutionary biology, psychology, and psychiatry, highlighting the inherent social nature of humans. This study proposes a theory that expands insulin’s role beyond traditional metabolic functions, incorporating it into the Mitochondrial Information Processing System (MIPS) and exploring it from an evolutionary medicine perspective to explore its function in processing psychological and social factors into biological responses. This narrative review comprises data from preclinical animal studies, longitudinal cohort studies, cross-sectional studies, machine learning analyses, and randomized controlled trials, and investigates the role of insulin in health and disease. The result is a proposal for a theoretical framework of insulin as a social substance within the socio-psycho-biological framework, emphasizing its extensive roles in health and disease. Type 2 Diabetes Mellitus (T2DM) with musculoskeletal disorders and neurodegeneration exemplifies this narrative. We suggest further research towards a comprehensive treatment protocol meeting evolutionary expectations, where incorporating psychosocial interventions plays an essential role. By supporting the concept of ‘insulin resilience’ and suggesting the use of heart rate variability to assess insulin resilience, we aim to provide an integrative approach to managing insulin levels and monitoring the effectiveness of interventions. This integrative strategy addresses broader socio-psychological factors, ultimately improving health outcomes for individuals with T2DM and musculoskeletal complications and neurodegeneration while providing new insights into the interplay between socio-psychological factors and biological systems in chronic diseases.

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Cold Exposure–induced Alterations in the Brain Peptidome and Gut Microbiome Are Linked to Energy Homeostasis in Mice

Cited by 3 publications

References 57 publications

Dietary-fat supplementation alleviates cold temperature-induced metabolic dysbiosis and barrier impairment by remodeling gut microbiota

Dietary-fat supplementation alleviates cold temperature-induced metabolic dysbiosis and barrier impairment by remodeling gut microbiota

Native Mass Spectrometry-Centric Approaches Revealed That Neuropeptides Frequently Interact with Amyloid-β

The Role of Insulin Within the Socio-Psycho-Biological Framework in Type 2 Diabetes—A Perspective from Psychoneuroimmunology

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