Cold exposure induced oxidative stress and apoptosis in the myocardium by inhibiting the Nrf2-Keap1 signaling pathway

Cong, Peifang; Liu, Yunen; Liu, Nannan; Zhang, Yubiao; Tong, Changci; Shi, Lin; Liu, Xuelei; Shi, Xiuyun; Liu, Ying; Tong, Zhou; Hou, Mingxiao

doi:10.1186/s12872-018-0748-x

Cited by 44 publications

(39 citation statements)

References 53 publications

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“…These differences may be related to the extent and duration of cold stress in different experiments. Evaluation of cardiac function using echocardiography has indicated that cold stress decreases in ejection fraction and shortening fraction of mouse hearts, leading to dampened LV function (Zhang et al, 2012b;Jiang et al, 2013;Yin et al, 2015;Cong et al, 2018).…”

Section: Myocardial Pathophysiological Changes Induced By Cold Stressmentioning

confidence: 99%

Unraveling the Mystery of Cold Stress-Induced Myocardial Injury

Kong

Sun

et al. 2020

Front. Physiol.

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Exposure to low ambient temperature imposes great challenge to human health. Epidemiological evidence has noted significantly elevated emergency admission and mortality rate in cold climate in many regions, in particular, adverse events in cardiovascular system. Cold stress is becoming one of the important risk factors for cardiovascular death. Through recent advance in echocardiography and myocardial histological techniques, both clinical and experimental experiments have unveiled that cold stress triggers a variety of pathological and pathophysiological injuries, including ventricular wall thickening, cardiac hypertrophy, elevated blood pressure, decreased cardiac function, and myocardial interstitial fibrosis. In order to examine the potential mechanism of action behind cold stress-induced cardiovascular anomalies, ample biochemical and molecular biological experiments have been conducted to denote a role for mitochondrial injury, intracellular Ca 2+ dysregulation, generation of reactive oxygen species (ROS) and other superoxide, altered gene and protein profiles for apoptosis and autophagy, and increased adrenergic receptor sensitivity in cold stress-induced cardiovascular anomalies. These findings suggest that cold stress may damage the myocardium through mitochondrial injury, apoptosis, autophagy, metabolism, oxidative stress, and neuroendocrine pathways. Although the precise nature remains elusive for cold stress-induced cardiovascular dysfunction, endothelin (ET-A) receptor, endoplasmic reticulum (ER) stress, transient receptor potential vanilloid, mitochondrial-related protein including NRFs and UCP-2, ROS, Nrf2-Keap1 signaling pathway, Bcl-2/Bax, and lipoprotein lipase (LPL) signaling may all play a pivotal role. For myocardial injury evoked by cold stress, more comprehensive and in-depth mechanisms are warranted to better define the potential therapeutic options for cold stress-associated cardiovascular diseases.

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Section: Myocardial Pathophysiological Changes Induced By Cold Stressmentioning

confidence: 99%

Unraveling the Mystery of Cold Stress-Induced Myocardial Injury

Kong

Sun

et al. 2020

Front. Physiol.

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“…However, in the present study,MDA content,which re ects the extent of cell damage [42], was decreased in the cold-exposed sheep. We speculate that the high levels of antioxidant enzymes, such as SOD [43], CAT [44], and GSH-PX [45], in plasma under cold temperature led to the degradation of the oxygen free radicals produced by sheep metabolism [46]. Studies have shown that low levels of cold stress enhance antioxidant capacity and reduce the body's exposure to the effects of oxidative stress [47].…”

Section: Discussionmentioning

confidence: 99%

Effects of Low Temperature and Wind Treatment on Physiological Indexes, Rumen Microbiota, Immune Responses and Hormones in Sheep

Guo¹,

Zhou²,

Tian³

et al. 2020

Preprint

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Background: Low-temperature environments can strongly affect the normal growth and health of livestock. Previous studies have shown that cold exposure can alter the intestinal microbiota and thereby affect other traits. In winter, cold weather can be accompanied by strong winds that aggravate the effects of cold on livestock. In this study, an experiment was conducted to investigate the effect of low temperature and wind speed on physiological indexes, rumen microbiota, and immune responses in sheep.Methods: The sheep were divided into control group and test group according to their ambient temperature.Sheep in the test group were divided into four groups according to wind-speed treatment: no wind (average wind velocity less than 0.5 m/s), low wind velocity (average wind velocity of 3 m/s), medium wind velocity (average wind velocity of 4 m/s) and high wind velocity (average wind velocity of 5 m/s).Results: Average daily gain and the utilization of forage, especially soluble fiber, decreased with increasing wind velocity in cold temperature (P<0.05). In rumen, the enzyme activity of cellulose degradation was also lowerwith increasing wind velocity (P<0.05). The abundance of potentially beneficial bacteria showed differedamong the wind treatments (P<0.05).The large fluctuations in the amount of bacteria provided a breeding opportunity forpotentially harmful bacteria (P<0.05). In addition, there were significant decreases in the serum levels of IL-2 and IFN-γ (P<0.05) and a large increase in IL-4 level (P<0.05), which indicated that the sheep underwent immune suppressionduring the trial. The significant increase in the activities of the antioxidant enzymes SOD, GSH-PX, and CAT (P<0.05) indicated that the production of oxygen free radicals was increased.Conclusions: The cold environment significantly reduced the growth of sheep and altered the composition of rumen microbiota, reducing the utilization of soluble fiber by the rumen flora. Furthermore, the sheep produced large amounts of enzymes to resist tissue damage and experienced immune suppression in the cold environment.

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“…The Least Square Adjustment (LSA) method is often used to achieve optimum solution in PAI (Tamim 1995, Wolf and Ghilani 2006, Merritt and Masters 1999, Gielsdorf et al 2004, Merritt 2005, Tong et al 2005, Casado 2006, Hope et al 2008, Tong et al 2009. LSA is used widely in the disciplines of surveying where this method is more advanced technique which adjusts observations based on the laws of probability, which models the occurrence of random errors.…”

Section: Positional Accuracy Iprovementmentioning

confidence: 99%

“…Merritt and Masters (1999) and Merritt (2005) developed the spatial adjustment engine based on the LSA to improve the accuracy of cadastral data in Australia. Tong et al (2005) presented a LSA model to resolve inconsistencies between the digitized and registered areas of cadastral parcels, and further improved the adjustment model by introducing scale parameters to reduce the influence of systematic error in the adjustment. Felus (2007) used LSA to enhance the spatial accuracy of digital cadastral maps via stochastic constraints and geometric conditions.…”

Section: Positional Accuracy Iprovementmentioning

confidence: 99%

Cadastral Positioning Accuracy Improvement (Pai): A Case Study of Pre-Requisite Data Quality Assurance

Hashim

Omar

Omar³

et al. 2019

Int. Arch. Photogramm. Remote Sens. Spatial Inf. Sci.

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Abstract. Nowadays, there is an increasing need for comprehensive spatial data management especially digital cadastral database (DCDB). Previously, the cadastral database is in hard copy map, then converted into digital format and subsequently updated. Theoretically, these legacy datasets have relatively low positional accuracy caused by limitation of traditional measurement, adjustment technique and technology changes over time. With the growth of spatial based technology especially Geographical Information System (GIS) and Global Navigation Satellite System (GNSS) the Positional Accuracy Improvement (PAI) to the legacy cadastral database is inevitable. PAI is the refining process of the geometry feature in a geospatial dataset through integration between legacy and higher accuracy dataset to improve its actual position. However, by merely integrating both datasets will lead to a distortion of the relative geometry. Thus, an organized method is required to minimize inherent errors in fitting to the new accurate dataset. The focus of this study is to design a comprehensive data preparation for legacy cadastral datasets improvement. The elements of datum traceability, cadastral error propagation and weightage setting in adjustment will be focused to achieve the targeted objective. The proposed result can be applied as a foundation for PAI approach in cadastral database modernization.

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Cold exposure induced oxidative stress and apoptosis in the myocardium by inhibiting the Nrf2-Keap1 signaling pathway

Cited by 44 publications

References 53 publications

Unraveling the Mystery of Cold Stress-Induced Myocardial Injury

Unraveling the Mystery of Cold Stress-Induced Myocardial Injury

Effects of Low Temperature and Wind Treatment on Physiological Indexes, Rumen Microbiota, Immune Responses and Hormones in Sheep

Cadastral Positioning Accuracy Improvement (Pai): A Case Study of Pre-Requisite Data Quality Assurance

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