Cold‐pressed Canola Oil Reduces Hepatic Steatosis by Modulating Oxidative Stress and Lipid Metabolism in KM Mice Compared with Refined Bleached Deodorized Canola Oil

Abstract

The quality of canola oil is affected by different extraction methods. The effect of cold‐pressed canola oil (CPCO) diet and traditional refined bleached deodorized canola oil (RBDCO) diet on lipid accumulation and hepatic steatosis in mice were investigated. The body weight, peroxisome proliferator‐activated receptor‐α concentration, serum lipid profile, insulin sensitivity, and oxidative stress were increased in mice fed with CPCO diet, which had higher unsaturated fatty acid, tocopherols, phytosterols, and phospholipids but lower saturated fatty acid than RBDCO, after 12 weeks,. Moreover, CPCO significantly increased tocopherols and phytosterols content in liver and reduced liver cholesterol contents and lipid vacuoles accumulation than RBDCO. Also, serum proinflammatory cytokines, 3‐hydroxy‐3‐methylglutary coenzyme A reductase expression level, lipogenic enzymes, and transcriptional factors such as sterol regulatory element‐binding proteins 1c, acetyl‐CoA carboxylase, and fatty acid synthase in the liver were also markedly downregulated from CPCO diet mice. Overall, CPCO can reduce lipid accumulation and hepatic steatosis by regulating oxidative stress and lipid metabolism in Kun Ming mice compared with RBDCO. Practical Application The results suggested that more bioactive components were contained in cold‐pressed canola oil (CPCO) rather than refined bleached deodorized canola oil (RBDCO). CPCO could lower the risk of obesity and hyperlipidemia, reduce lipid accumulation, and prevent hepatic steatosis. It could be considered as a kind of better edible oil than RBDCO.

Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice

“…Previous studies have shown that cases of glycolipid metabolism disorders exhibit elevated levels of inflammatory cytokines, such as IL-6, TNF-α, and MCP-1 in the adipose tissue. In fact, this phenomenon negatively affects IR and lipid metabolism and is accompanied by inflammation . Our results revealed that chrysin caused a significant downregulation of three inflammatory factors in serum in the HF group, consistent with previous reports that have also shown that chrysin exerts anti-inflammatory activity .…”

Changes in Growth, Physiology, and Fatty Acid Profile of Rapeseed Cultivars Treated with Vermicompost Under Drought Stress

“…Rapeseed/canola (Brassica napus L.) is mainly specified as a major oilseed crop due to its high oil content and the useful fatty acid compositions (Zhou et al 2019;Mamnabi et al 2020). This crop has been largely cultivated all over the world in recent years (Torkaman et al 2018).…”

Sea Cucumber Sterol Alleviates the Lipid Accumulation in High-Fat–Fructose Diet Fed Mice

“…Mechanism studies showed that dietary administration with sea cucumber sterol for 8 weeks significantly reduced the expression of ACC and FAS involved in lipid synthesis, which was consistent with previous studies. 53,54 Interestingly, sea cucumber sterol exhibited better effects in comparison to phytosterol in remarkably enhancing the expressions of CPT1 and ACOX1 related to fatty acid β-oxidation. The above results showed that sea cucumber sterol was superior to phytosterol in regulating the synthesis and β-oxidation of fatty acids, which may due to the sulfate groups in the structure.…”