Cold‐Responsive Nanocapsules Enable the Sole‐Cryoprotectant‐Trehalose Cryopreservation of β Cell–Laden Hydrogels for Diabetes Treatment

Cheng, Yue; Yu, Yunru; Zhang, Yuntian; Zhao, Gang; Zhao, Yuanjin

doi:10.1002/smll.201904290

Cited by 41 publications

(33 citation statements)

References 67 publications

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13] Hierarchical core-shell nanocapsules are promising carriers that could encapsulate various oil actives in a polymer shell, protect them from harsh ambient conditions and release them when it is required. [14][15][16][17][18][19] Encapsulation of the oil actives in the nanocapsules can effectively alleviate their deficiencies of low stability and poor dispersity in water, thus increasing their bioavailability. [20] For example, many food active molecules, such as antioxidants and aromas, exist in an oil form and effective encapsulation of the oils in the core of nanocapsules is generally required for practical applications.…”

Section: Introductionmentioning

confidence: 99%

Active Encapsulation in Biocompatible Nanocapsules

Yang

et al. 2020

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Co-precipitation is generally referred to the co-precipitation of two solids and is widely used to prepare active-loaded nanoparticles. Here, we demonstrate that liquid and solid could precipitate simultaneously to produce hierarchical core-shell nanocapsules that encapsulate an oil core in a polymer shell. During the co-precipitation process, the polymer preferentially deposits at the oil/water interface, wetting both the oil and water phases; the behavior is determined by the spreading coefficients and driven by the energy minimization. The technique is applicable to directly encapsulate various oil actives and avoid the use of toxic solvent or surfactant during the preparation process. The obtained core-shell nanocapsules harness the advantage of biocompatibility, precise control over the shell thickness, high loading capacity, high encapsulation efficiency, good dispersity in water and improved stability against oxidation. The applications of the nanocapsules as delivery vehicles are demonstrated by the excellent performances of natural colorant and anti-cancer drug-loaded nanocapsules. The core-shell nanocapsules with a controlled hierarchical structure are, therefore, ideal carriers for practical applications in food, cosmetic and drug delivery.Received: ((will be filled in by the editorial staff))Revised: ((will be filled in by the editorial staff)) Published online: ((will be filled in by the editorial staff)) nanocapsules (blue columns), suggesting that the nanocapsules are biocompatible and are ideal carriers for anti-cancer drugs.Hierarchical core-shell nanocapsules are developed by controlled co-precipitation and phase separation. The core-shell nanocapsules serve as excellent delivery vehicles and possess tunable shell thickness, high encapsulation efficiency, high loading capacity, good dispersity in water, improved stability and pH-triggered release, which opens a door to a range of new applications in food, cosmetic and drug delivery.

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Section: Introductionmentioning

confidence: 99%

Active Encapsulation in Biocompatible Nanocapsules

Yang

et al. 2020

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“…Likewise, Alg. has exhibited an outstanding potential for different biomedical applications with special concern to tissue engineering, drug delivery, wound dressing, and ex vivo cell culture owing to their unique characters and mild gelling circumstances [ 275 , 342 , 343 ]. BC is a versatile, key biomaterial for upcoming state-of-the-art applications in regenerative medicine especially, tissue engineering and wound reconstruction.…”

Section: Smart/stimuli-responsive Hydrogels Employed For Different Biomedical Applicationsmentioning

confidence: 99%

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

El-Husseiny

Mady

Hamabe

et al. 2022

Materials Today Bio

222

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Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left the door open for further improvement of their applications to revitalize the impaired tissues. Hence, restoring their functions. The implementation of therapeutic protocols that merge biomimetic scaffolds, bioactive molecules, and cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended for tissue engineering and other biomedical purposes. They can simulate the physicochemical, mechanical, and biological characters of the innate tissues. Also, they provide the aqueous conditions for cell growth, support 3D conformation, provide mechanical stability for the cells, and serve as potent delivery matrices for bioactive molecules. Many natural and artificial polymers were broadly utilized to design these intelligent platforms with novel advanced characteristics and tailored functionalities that fit such applications. In the present review, we highlighted the different types of smart/stimuli-responsive hydrogels with emphasis on their synthesis scheme. Besides, the mechanisms of their responsiveness to different stimuli were elaborated. Their potential for tissue engineering applications was discussed. Furthermore, their exploitation in other biomedical applications as targeted drug delivery, smart biosensors, actuators, 3D and 4D printing, and 3D cell culture were outlined. In addition, we threw light on smart self-healing hydrogels and their applications in biomedicine. Eventually, we presented their future perceptions in biomedical and tissue regeneration applications. Conclusively, current progress in the design of smart/stimuli-responsive hydrogels enhances their prospective to function as intelligent, and sophisticated systems in different biomedical applications.

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“…In case of mismatch between donor and recipient time, there is a need to find efficient cryopreservation techniques. Combining cold-sensitive hydrogels with appropriate encapsulation techniques allows islets to not only survive the freeze-thaw process, but also provide a natural barrier to islets in vivo ( 33 ). In a specific temperature range, thermo-responsive polymers undergo phase transition due to the formation of intermolecular hydrogen bonds, hydrophobic interactions and physical entanglement of polymer chains ( 34 ).…”

Section: Design Rules For Islets Encapsulationmentioning

confidence: 99%

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Zhang

Gonelle‐Gispert

et al. 2022

Front. Immunol.

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Islet transplantation is a promising approach for the treatment of type 1 diabetes (T1D). Currently, clinical islet transplantation is limited by allo - and autoimmunity that may cause partial or complete loss of islet function within a short period of time, and long-term immunosuppression is required to prevent rejection. Encapsulation into semipermeable biomaterials provides a strategy that allows nutrients, oxygen and secreted hormones to diffuse through the membrane while blocking immune cells and the like out of the capsule, allowing long-term graft survival and avoiding long-term use of immunosuppression. In recent years, a variety of engineering strategies have been developed to improve the composition and properties of encapsulation materials and to explore the clinical practicality of islet cell transplantation from different sources. In particular, the encapsulation of porcine islet and the co-encapsulation of islet cells with other by-standing cells or active ingredients for promoting long-term functionality, attracted significant research efforts. Hydrogels have been widely used for cell encapsulation as well as other therapeutic applications including tissue engineering, cell carriers or drug delivery. Here, we review the current status of various hydrogel biomaterials, natural and synthetic, with particular focus on islet transplantation applications. Natural hydrophilic polymers include polysaccharides (starch, cellulose, alginic acid, hyaluronic acid, chitosan) and peptides (collagen, poly-L-lysine, poly-L-glutamic acid). Synthetic hydrophilic polymers include alcohol, acrylic acid and their derivatives [poly (acrylic acid), poly (methacrylic acid), poly(acrylamide)]. By understanding the advantages and disadvantages of materials from different sources and types, appropriate materials and encapsuling methods can be designed and selected as needed to improve the efficacy and duration of islet. Islet capsule transplantation is emerging as a promising future treatment for T1D.

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Cold‐Responsive Nanocapsules Enable the Sole‐Cryoprotectant‐Trehalose Cryopreservation of β Cell–Laden Hydrogels for Diabetes Treatment

Cited by 41 publications

References 67 publications

Active Encapsulation in Biocompatible Nanocapsules

Active Encapsulation in Biocompatible Nanocapsules

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

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