“…Five intervention studies used cold application [8,[20][21][22]24], and 5 intervention studies used cold application plus a standard drug treatment [3,4,7,19,23]. The intervention durations varied from 10 minutes to 20 minutes [3,4,8,11,[20][21][22][23], and 2 studies showed that cold application applied to the skin dropped the skin temperature to 13.6°C before CTR [7,24]. The cold application was applied to the area surrounding the chest tube with 9-inch[8], 7-cm[24], 5-cm [23], and 6-inch [22] diameters.…”