Colistin-Loaded Silk Membranes against Wound Infection with Pseudomonas aeruginosa

Steinstraesser, Lars; Trust, Galina; Rittig, A.; Hirsch, Tobias; Kesting, Marco; Steinau, Hans-Ulrich; Jacobsen, Frank

doi:10.1097/prs.0b013e31820cf29a

Cited by 13 publications

(8 citation statements)

References 23 publications

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“…Sustained delivery of antibiotics can be achieved by encapsulation into different hydrogel-based systems such as gelatin (Nunes et al, 2016 ), keratin (Roy et al, 2016 ), or chitosan (Hurler et al, 2012 ). Antibiotic incorporation into electrospun dressings (Chen et al, 2016 ; Dhand et al, 2016 , 2017 ) and occlusive dressings (Steinstraesser et al, 2011 ) has also shown superior activity and accelerated wound healing when compared to current clinical silver-based products.…”

Section: Inflammationmentioning

confidence: 99%

Advancements in Regenerative Strategies Through the Continuum of Burn Care

et al. 2018

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Burns are caused by several mechanisms including flame, scald, chemical, electrical, and ionizing and non-ionizing radiation. Approximately half a million burn cases are registered annually, of which 40 thousand patients are hospitalized and receive definitive treatment. Burn care is very resource intensive as the treatment regimens and length of hospitalization are substantial. Burn wounds are classified based on depth as superficial (first degree), partial-thickness (second degree), or full-thickness (third degree), which determines the treatment necessary for successful healing. The goal of burn wound care is to fully restore the barrier function of the tissue as quickly as possible while minimizing infection, scarring, and contracture. The aim of this review is to highlight how tissue engineering and regenerative medicine strategies are being used to address the unique challenges of burn wound healing and define the current gaps in care for both partial- and full-thickness burn injuries. This review will present the current standard of care (SOC) and provide information on various treatment options that have been tested pre-clinically or are currently in clinical trials. Due to the complexity of burn wound healing compared to other skin injuries, burn specific treatment regimens must be developed. Recently, tissue engineering and regenerative medicine strategies have been developed to improve skin regeneration that can restore normal skin physiology and limit adverse outcomes, such as infection, delayed re-epithelialization, and scarring. Our emphasis will be centered on how current clinical and pre-clinical research of pharmacological agents, biomaterials, and cellular-based therapies can be applied throughout the continuum of burn care by targeting the stages of wound healing: hemostasis, inflammation, cell proliferation, and matrix remodeling.

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Section: Inflammationmentioning

confidence: 99%

Advancements in Regenerative Strategies Through the Continuum of Burn Care

et al. 2018

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“…In 1968, Mason and Walker developed the first burn model in rats that used boiling water to inflict a scald injury [26]. This model has been widely used for studying burn infections, Pseudomonas aeruginosa infection and potential treatment [27], bacterial translocation and intestinal atrophy after thermal injury [28], burn sepsis [29,30], candidiasis after thermal injury [31], and gene therapy [32,33]. Bjornson et al [34] developed a similar model using guinea pigs to study burn wounds infected with Staphylococcus aureus, P. aeruginosa, and Candida albicans.…”

Section: Animal Models Of Burns and Burn Infectionmentioning

confidence: 99%

Novel pharmacotherapy for burn wounds: what are the advancements

Hamblin

2018

Expert Opinion on Pharmacotherapy

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Introduction:The prognosis for severe burns has improved significantly over the past 50 years. Meanwhile, burns have become an affliction mainly affecting the less well-developed regions of the world. Early excision and skin grafting has led to major improvements in therapeutic outcomes. Areas covered:The purpose of this article is to survey the use of pharmacotherapy to treat different pathophysiological complications of burn injury. The author, herein, discusses the use of drug treatments for a number of systemic metabolic disturbances including hyperglycemia, elevated catabolism, and gluconeogenesis. Expert opinion:Advancements in personalized and molecular medicine will make an impact on burn therapy. Similarities between severe burns and other critically ill patients will lead to crossfertilization between different medical specialties. Furthermore, advances in stem cells and tissue regeneration will lead to improved healing and less lifelong disability. Indeed, research in new drug therapy for burns is actively progressing for many different complications.

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“…This procedure produces a uniform partial-thickness burn (three seconds of exposure) or a full-thickness burn (ten seconds of exposure), covering approximately 30% TBSA. This model has been widely used for studying burn infections with pathogens such as Pseudomonas aeruginosa and potential treatments [16], bacterial translocation and intestinal atrophy after thermal injury [17], burn sepsis [18, 19], candidiasis after thermal injury [20], and gene therapy [21, 22]. …”

Section: Burns and Animal Models Of Burn Infectionmentioning

confidence: 99%

Topical Antimicrobials for Burn Infections – An Update

Sevgi¹,

Toklu²,

Vecchio³

et al. 2014

PRI

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The relentless rise in antibiotic resistance among pathogenic bacteria and fungi, coupled with the high susceptibility of burn wounds to infection, and the difficulty of systemically administered antibiotics to reach damaged tissue, taken together have made the development of novel topical antimicrobials for burn infections a fertile area of innovation for researchers and companies. We previously covered the existing patent literature in this area in 2010, but the notable progress made since then, has highlighted the need for an update to bring the reader up to date on recent developments. New patents in the areas of topically applied antibiotics and agents that can potentiate the action of existing antibiotics may extend their useful lifetime. Developments have also been made in biofilm-disrupting agents. Antimicrobial peptides are nature’s way for many life forms to defend themselves against attack by pathogens. Silver has long been known to be a highly active antimicrobial but new inorganic metal derivatives based on bismuth, copper and gallium have emerged. Halogens such as chlorine and iodine can be delivered by novel technologies. A variety of topically applied antimicrobials include chitosan preparations, usnic acid, ceragenins and XF porphyrins. Natural product derived antimicrobials such as tannins and essential oils have also been studied. Novel techniques to deliver reactive oxygen species and nitric oxide in situ have been developed. Light-mediated techniques include photodynamic therapy, ultraviolet irradiation, blue light, low-level laser therapy and titania photocatalysis. Passive immunotherapy employs antibodies against pathogens and their virulence factors. Finally an interesting new area uses therapeutic microorganisms such as phages, probiotic bacteria and protozoa to combat infections.

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Colistin-Loaded Silk Membranes against Wound Infection with Pseudomonas aeruginosa

Abstract: This study demonstrates that occlusive ST-silk membranes loaded with an antimicrobial agent may be an effective dressing for infected wounds.

Cited by 13 publications

References 23 publications

Advancements in Regenerative Strategies Through the Continuum of Burn Care

Advancements in Regenerative Strategies Through the Continuum of Burn Care

Novel pharmacotherapy for burn wounds: what are the advancements

Topical Antimicrobials for Burn Infections – An Update

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