Colistin Resistance in Aeromonas spp.

Gonzalez-Avila, Luis Uriel; Loyola-Cruz, Miguel Ángel; Hernández-Cortez, Cecilia; Bello–López, Juan Manuel; Castro-Escarpulli, Graciela

doi:10.3390/ijms22115974

Cited by 21 publications

(17 citation statements)

References 33 publications

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“…However, the more cytotoxic strain AG29E1 did present potentially more important enzymes from the point of view of antimicrobial resistance. An increase in the resistance of some Aeromonas species was reflected in recent studies [ 9 , 50 , 51 , 52 ]. This should alert us to remain vigilant regarding the epidemiology of resistance markers in these species.…”

Section: Discussionmentioning

confidence: 89%

“…The genus Aeromonas has received constant attention from different areas such as aquaculture and veterinary medicine [ 1 , 2 , 3 ], food safety [ 4 , 5 ], and clinical human microbiology [ 6 , 7 ]. Human infections by Aeromonas are more frequent and these strains have an increasing resistance to antibiotics [ 8 , 9 ]. Therefore, it is not only necessary to better understand antibiotic resistance in these species, but their virulence and pathogenicity mechanisms [ 10 ] as well.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity and Antimicrobial Resistance of Aeromonas Strains Isolated from Fresh Produce and Irrigation Water

et al. 2023

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The genus Aeromonas has received constant attention in different areas, from aquaculture and veterinary medicine to food safety, where more and more frequent isolates are occurring with increased resistance to antibiotics. The present paper studied the interaction of Aeromonas strains isolated from fresh produce and water with different eukaryotic cell types with the aim of better understanding the cytotoxic capacity of these strains. To study host-cell pathogen interactions in Aeromonas, we used HT-29, Vero, J774A.1, and primary mouse embryonic fibroblasts. These interactions were analyzed by confocal microscopy to determine the cytotoxicity of the strains. We also used Galleria mellonella larvae to test their pathogenicity in this experimental model. Our results demonstrated that two strains showed high cytotoxicity in epithelial cells, fibroblasts, and macrophages. Furthermore, these strains showed high virulence using the G. mellonella model. All strains used in this paper generally showed low levels of resistance to the different families of the antibiotics being tested. These results indicated that some strains of Aeromonas present in vegetables and water pose a potential health hazard, displaying very high in vitro and in vivo virulence. This pathogenic potential, and some recent concerning findings on antimicrobial resistance in Aeromonas, encourage further efforts in examining the precise significance of Aeromonas strains isolated from foods for human consumption.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and Antimicrobial Resistance of Aeromonas Strains Isolated from Fresh Produce and Irrigation Water

et al. 2023

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“…[ 56 , 57 , 58 ], our A. caviae , A. eucrenophila and A. hydrophila isolates were negative for all mcr genes tested ( mcr 1–5). Nevertheless, it is possible that these isolates have a novel variant of the mcr gene or another resistance mechanism, such as the addition of L-Ara-4N to the lipopolysaccharide layer [ 59 ]. Therefore, whole genome sequencing of these isolates would be required to fully elucidate the mechanism of colistin resistance.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Third Generation Cephalosporin- and Carbapenem-Resistant Aeromonas Isolates from Municipal and Hospital Wastewater

et al. 2023

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Antibiotic resistance (AR) remains one of the greatest threats to global health, and Aeromonas species have the potential to spread AR in the aquatic environment. The spread of resistance to antibiotics important to human health, such as third-generation cephalosporins (3GCs) and carbapenems, is of great concern. We isolated and identified 15 cefotaxime (3GC)- and 51 carbapenem-resistant Aeromonas spp. from untreated hospital and treated municipal wastewater in January 2020. The most common species were Aeromonas caviae (58%), A. hydrophila (17%), A. media (11%), and A. veronii (11%). Almost all isolates exhibited a multidrug-resistant phenotype and harboured a diverse plasmidome, with the plasmid replicons ColE, IncU, and IncR being the most frequently detected. The most prevalent carbapenemase gene was the plasmid-associated blaKPC-2 and, for the first time, the blaVIM-2, blaOXA-48, and blaIMP-13 genes were identified in Aeromonas spp. Among the 3GC-resistant isolates, the blaGES-5 and blaMOX genes were the most prevalent. Of the 10 isolates examined, three were capable of transferring carbapenem resistance to susceptible recipient E. coli. Our results suggest that conventionally treated municipal and untreated hospital wastewater is a reservoir for 3GC- and carbapenem-resistant, potentially harmful Aeromonas spp. that can be introduced into aquatic systems and pose a threat to both the environment and public health.

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“…This antibiotic can disrupt the membrane of gram-negative bacteria by interacting with surface LPS and is used as last resort for infections cause by multi-drug resistant microorganisms (MDR). Reports showed the existence of colistin-resistant Aeromonads, especially among the isolates obtained from clinical samples ( Gonzalez-Avila et al, 2021 ).…”

Section: Antibiotic Responses and Therapeutic Efficacymentioning

confidence: 99%

Aeromonas and Human Health Disorders: Clinical Approaches

et al. 2022

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The genus Aeromonas comprises more than 30 Gram-negative bacterial species and naturally inhabitants from aquatic environments. These microorganisms, commonly regarded as pathogens of fish and several other animals, have been gaining prominence on medical trial due to its ability to colonize and infect human beings. Besides water, Aeromonas are widely spreaded on most varied sources like soil, vegetables, and food; Although its opportunistic nature, they are able to cause infections on immunocompromised or immunocompetent patients. Aeromonas species regarded as potential human pathogens are usually A. hydrophila, A. caviae, and A. veronii biovar sobria. The main clinical manifestations are gastrointestinal tract disorders, wound, and soft tissue infections, as well as septicemia. Regarding to antibiotic responses, the bacteria present a diversified susceptibility profile and show inherence resistance to ampicillin. Aeromonas, as an ascending genus in microbiology, has been carefully studied aiming comprehension and development of methods for detection and medical intervention of infectious processes, not fully elucidated in medicine. This review focuses on current clinical knowledge related to human health disorders caused by Aeromonas to contribute on development of efficient approaches able to recognize and impair the pathological processes.

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Colistin Resistance in Aeromonas spp.

Cited by 21 publications

References 33 publications

Cytotoxicity and Antimicrobial Resistance of Aeromonas Strains Isolated from Fresh Produce and Irrigation Water

Cytotoxicity and Antimicrobial Resistance of Aeromonas Strains Isolated from Fresh Produce and Irrigation Water

Characterization of Third Generation Cephalosporin- and Carbapenem-Resistant Aeromonas Isolates from Municipal and Hospital Wastewater

Aeromonas and Human Health Disorders: Clinical Approaches

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