Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance

Qureshi, Zubair A.; Hittle, Lauren E.; O’Hara, Jessica A.; Rivera, Jesabel I.; Syed, Alveena; Shields, Ryan K.; Pasculle, A. William; Ernst, Robert K.; Doi, Yohei

doi:10.1093/cid/civ048

Cited by 358 publications

(310 citation statements)

References 36 publications

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“…While the number of reports on colistin resistance have gradually been increasing in other countries (14) and a report based on a study conducted in the United States showed that 5.3% of all Acinetobacter strains detected during an eight-year period were resistant to colistin (15,16), encounters with colistin-resistant Acinetobacter species are still rare in Japan. The production and sale of colistin in Japan was only approved in 2015.…”

Section: Discussionmentioning

confidence: 99%

An Intrinsic Strain of Colistin-resistant <i>Acinetobacter</i> Isolated from a Japanese Patient

et al. 2016

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We herein report the first domestic case of bacteremia caused by an intrinsic strain of colistin-resistant Acinetobacter. The Acinetobacter species was detected in the hemocultures in a febrile patient. The patient was a 65-year-old-man who was admitted to our hospital for laparotomic gastrostomy. The patient's antimicrobial susceptibility patterns were atypical; they were colistin resistant but not multiple drug resistant. A sequence analysis of rpoB identified the bacterium as an Acinetobacter genomic species 13BJ/14TU, which had only been previously reported in South Korea. He had never traveled to South Korea but frequently had contact with the South Korean community. We therefore demonstrated that infection with this species could occur in domestic cases.

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Section: Discussionmentioning

confidence: 99%

An Intrinsic Strain of Colistin-resistant <i>Acinetobacter</i> Isolated from a Japanese Patient

et al. 2016

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“…In such cases polymyxins are the only therapeutic solution. Unfortunately, the isolation of colistin-resistant carbapenem-resistant A. baumannii is on the rise [27] . A large spectrum of nosocomial infections are caused by A. baumannii including bloodstream infections, pneumonia, catheter-associated infections, etc.…”

Section: Acinetobacter Baumanniimentioning

confidence: 99%

Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients

Paramythiotou

Routsi

2016

WJCCM

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The incidence of gram-negative multidrug-resistant (MDR) bacterial pathogens is increasing in hospitals and particularly in the intensive care unit (ICU) setting. The clinical consequences of infections caused by MDR pathogens remain controversial. The purpose of this review is to summarize the available data concerning the impact of these infections on mortality in ICU patients. Twenty-four studies, conducted exclusively in ICU patients, were identified through PubMed search over the years 2000-2015. Bloodstream infection was the only infection examined in eight studies, respiratory infections in four and variable infections in others. Comparative data on the appropriateness of empirical antibiotic treatment were provided by only seven studies. In ten studies the presence of antimicrobial resistance was not associated with increased mortality; on the contrary, in other studies a significant impact of antibiotic resistance on mortality was found, though, sometimes, mediated by inappropriate antimicrobial treatment. Therefore, a direct association between infections due to gram-negative MDR bacteria and mortality in ICU patients cannot be confirmed. Sample size, presence of multiple confounders and other methodological issues may influence the results. These data support the need for further studies to elucidate the real impact of infections caused by resistant bacteria in ICU patients.

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“…Qureshi ZA et al found that all 19 patients initially infected with colistin-susceptible A. baumannii received therapy with intravenous CMS, inhaled CMS, or both, prior to isolation of colistin-resistant A. baumannii and the median interval between the isolation of the colistinsusceptible A. baumannii isolate and the colistin-resistant A. baumannii isolate was 20 days (range, 4-99). They also observed an all-cause mortality of 30% (6/20) at 30 days (45).…”

Section: Combination Therapymentioning

confidence: 89%

Intravenous polymyxins: Revival with puzzle

Fei

et al. 2017

BST

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Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance

Cited by 358 publications

References 36 publications

An Intrinsic Strain of Colistin-resistant <i>Acinetobacter</i> Isolated from a Japanese Patient

An Intrinsic Strain of Colistin-resistant <i>Acinetobacter</i> Isolated from a Japanese Patient

Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients

Intravenous polymyxins: Revival with puzzle

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