Colitis Associated with Nintedanib Therapy for Idiopathic Pulmonary Fibrosis (IPF)

Nintedanib-Induced Colitis Can Mimic Inflammatory Bowel Disease

“…7 A literature search identified 9 cases of nintedanib-induced colitis. [8][9][10][11][12][13][14][15] Our study of 3 patients with nintedanib-induced colitis significantly adds to the limited literature on this topic (summarized in Table 1). In our patients, the average age was 69 years, with 67% being female.…”

“…The current 3 patient presentations are consistent with the 9 previously reported cases of nintedanib-induced colitis, including radiographic, endoscopic, or histologic evidence of colitis associated with nintedanib use. [8][9][10][11][12][13][14][15] In previous literature, the average age was 68 years, with 89% being male.…”

“…The current 3 patient presentations are consistent with the 9 previously reported cases of nintedanib-induced colitis, including radiographic, endoscopic, or histologic evidence of colitis associated with nintedanib use. 8–15 In previous literature, the average age was 68 years, with 89% being male. Gastrointestinal adverse effects began a few days after starting therapy to as long as to 1.5 years 8 after initiation of nintedanib.…”

Inflammatory Bowel Disease-Mimicking Colitis Associated With Nintedanib-Based Therapy in a Lung Cancer Patient

“…Although the authors described the colitis as chronic active, no histologic signs of chronicity (eg, crypt distortion or basal plasmacytosis) were described in the text or demonstrated on the figures. 5 Further 2 case studies of a 68-year-old and a 61-year-old male patient reported histological findings of acute superficial inflammation and increased lymphoplasmacytic infiltration of the lamina propria, but again, no signs of crypt architectural distortion or basal plasmacytosis were documented. 6,7 According to Chandler's research, a causal relationship between nintedanib therapy and ischemic colitis was hypothesized based on the analysis of spontaneous reports of suspected adverse drug reactions and observational data from large health care databases.…”

“…Only a handful of nintedanib-associated colitis cases, mostly with superficially active and focally active morphologies, have been reported. 5‐7 Probable nintedanib-associated colitis was first described by Oda et al in 2017. Although the authors described the colitis as chronic active, no histologic signs of chronicity (eg, crypt distortion or basal plasmacytosis) were described in the text or demonstrated on the figures.…”