Colitis fulminante por Clostridium difficile

Gómez, Inmaculada Torrijo; Quintana, Natalia Uribe; Llosa, Jesús Catalá; Vázquez, Juan Raga; Dechent, Rafael Sellés; Dieguez, M. Carmen Martín; Requena, Gloria Báguena; Arana, Francisco Asencio

doi:10.1016/j.gastrohep.2016.01.007

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…The first official clinical trial in humans was completed in 1958, to treat four patients with fulminant pseudomembranous colitis, which is the result of a severe C. difficile infection that causes acute inflammation of the colon and systemic toxicity. These patients were treated with a fecal enema, and all four patients were deemed healthy, with no symptoms of infection, shortly after the enema was completed [ 90 , 91 ]. Since then, FMT has been used to treat ulcerative colitis, constipation, diarrhea, abdominal pain, Crohn’s disease, and C. difficile infections all with generally high effectiveness [ 92 ].…”

Section: Microbiome Transplantsmentioning

confidence: 99%

Gut Microbiome Transplants and Their Health Impacts across Species

Levine

Hoffman

2023

Microorganisms

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The human gut, required for ingesting and processing food, extracting nutrients, and excreting waste, is made up of not just human tissue but also trillions of microbes that are responsible for many health-promoting functions. However, this gut microbiome is also associated with multiple diseases and negative health outcomes, many of which do not have a cure or treatment. One potential mechanism to alleviate these negative health effects caused by the microbiome is the use of microbiome transplants. Here, we briefly review the gut’s functional relationships in laboratory model systems and humans, with a focus on the different diseases they directly affect. We then provide an overview of the history of microbiome transplants and their use in multiple diseases including Alzheimer’s disease, Parkinson’s disease, as well as Clostridioides difficile infections, and irritable bowel syndrome. We finally provide insights into areas of research in which microbiome transplant research is lacking, but that simultaneously may provide significant health improvements, including age-related neurodegenerative diseases.

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Section: Microbiome Transplantsmentioning

confidence: 99%