Collaborating in Africa—small steps to sustainable success

Israëls, Trijn; Molyneux, Elizabeth

doi:10.1038/nrclinonc.2014.189

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…Treatment abandonment is the most common cause of treatment failure in low‐income countries and largely preventable with financial support . The aim of the project is to decrease abandonment to below 10% . We know from previous experience in Malawi, where it was reduced to 6%, that this is possible with these simple but appropriate interventions …”

Section: Discussionmentioning

confidence: 99%

“…The SIOP Africa/PODC Collaborative WT Africa Project has implemented this comprehensive WT guideline in eight centres in five sub‐Saharan African countries as a prospective clinical trial with uniform outcome evaluation (Supplementary Fig. S1 shows a map of Africa and participating centres) …”

Section: Introductionmentioning

confidence: 99%

“…The aim of the collaborative project is to reduce both treatment abandonment and death during treatment to less than 10% and to increase 2‐year EFS to 50% . Enrolment started in January 2014 and is still continued.…”

Section: Introductionmentioning

confidence: 99%

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Improved outcome at end of treatment in the collaborative Wilms tumour Africa project

Israëls

Paintsil

Nyirenda

et al. 2018

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Improved outcome at end of treatment in the collaborative Wilms tumour Africa project

Israëls

Paintsil

Nyirenda

et al. 2018

Pediatric Blood & Cancer

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“… 47 Inconsistent and weak ethical regulations are experienced as barriers to progress, and there has been little incentive to include African researchers in trial design and publication. 7 The pediatric population is largely excluded from treatment trials because Africa has no regulatory requirements, such as legislated by the European Pediatric Medicines Regulation for treatments to be studied in children and adolescents for market approval. 48 …”

Section: Discussionmentioning

confidence: 99%

“…The ability to participate in clinical trials is intertwined with the capacity of local pediatric oncology units (POUs) to deliver clinical services in a severely resource-constrained environment. 7 Historically, many services and research projects were established in collaboration with North American and European groups. In addition, regional African collaborations and training programs have led to studies that were influenced by regional priorities, socioeconomic factors, and availability of resources.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives

Heerden

Zaghloul

Neven

et al. 2020

JCO Global Oncology

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PURPOSE Adequate clinical services have yet to be established in the majority of African countries, where childhood cancer survival rates vary from 8.1% to 30.3%. The aim of this review is to describe the landscape of pediatric oncology trials in Africa, identify challenges, and offer future opportunities for research collaborations. METHODS The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials.gov, and a literature overview of publications on the subject of pediatric oncology clinical research supported by expert opinions on the current situation and challenges. RESULTS The SIOP global mapping survey received responses from 47 of 54 African countries, of which 23 have active clinical research programs. A preliminary search of ClinicalTrials.gov showed that only 105 (12.1%) of 868 African oncology studies included children and adolescents. Of these, 53 (50.5%) were interventional trials according to the registry’s classification. The small number of African trials for children and adolescents included palliative care and leukemia trials. In African oncology journals and international pediatric oncology journals, < 1% of the pediatric oncology publications come from Africa. Services and research were strengthened by international collaboration. National studies focused on clinical needs, local challenges, or interventional priorities. Both the literature review and the expert opinions highlight the need to expand clinical research in Africa, despite ongoing regional instability and lack of resources. CONCLUSION While a low number of pediatric clinical treatment trials are open to African children and adolescents, clinical research of high quality is being done in Africa. Several initiatives are stimulating the development of the research capacity across the continent, which should increase the publication output.

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Reflections on 20 years of the Wilms Africa project: Lessons learned and the way forward

Israels,

Borgstein,

Kamiza

et al. 2024

Pediatric Blood & Cancer

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Collaborating in Africa—small steps to sustainable success

Cited by 5 publications

References 9 publications

Improved outcome at end of treatment in the collaborative Wilms tumour Africa project

Improved outcome at end of treatment in the collaborative Wilms tumour Africa project

Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives

Reflections on 20 years of the Wilms Africa project: Lessons learned and the way forward

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