CollAborative care for Screen-Positive EldeRs with major depression (CASPER plus): a multicentred randomised controlled trial of clinical effectiveness and cost-effectiveness

Abstract

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: journals.library@nihr.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: http://www.nets.nihr.ac.uk/programmes/hta This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 10/57/43. The contractual start date was in September 2012. The draft report began editorial review in July 2016 and was accepted for publication in February 2017. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health. Published by ...

Depression in older adults

“…The editorial6 published by The BMJ in 2004 proposed Collaborative Care to help older people with depression, especially those with chronic physical and social problems, and there have been recent positive findings from a large UK trial 12…”

Non-traditional support workers delivering a brief psychosocial intervention for older people with anxiety and depression: the NOTEPAD feasibility study

“…A suggested recruitment strategy for future studies would be to send invitations to people aged > 65 years with two or more long-term physical conditions rather than to all registered patients aged > 65 years, as in the CASPER plus trial. [42][43][44] An alternative approach in future studies would be to recruit people already on antidepressants, as nearly half of participants in the NOTEPAD study were taking medication. Aiming to recruit people who live alone is difficult as 'living alone' is unlikely to be Read coded on GP computer systems.…”

“…In the CASPER plus (CollAborative care for Screen-Positive EldeRs with major depression) trial, [42][43][44] the BA intervention was acceptable for many of the older adults with depression and could readily be delivered over the telephone, following a face-to-face meeting. This approach may be able to reduce the stigma of the label of mental illness and resolve misconceptions around antidepressant medication prescribed by GPs.…”

The effectiveness of patient-centred medical home-based models of care versus standard primary care in chronic disease management: a systematic review and meta-analysis of randomised and non-randomised controlled trials

“…10). The substantial heterogeneity of 81% was due to higher costs of intervention reported by Bosanquet et al [46].…”

“…Meta-analysis of thirty-one studies [13, 14, 18, 19, 36, 38, 40, 42, 43, 46, 50, 51, 53, 55, 57, 63, 67, 68, 70, 76, 78, 83, 84, 86-88, 91, 93, 100, 102, 109] of patients with minor or major depression episodes after PCMH-based care reported signi cant improvement in depression scores compared to patients with standard primary care. With the exceptions of three studies [46,91,102], twentytwo studies reporting changes in mean differences (continuous data) of depression scores showed signi cant reduction with a pooled SMD of -0.24 (95% CI -0.35, -0.14; p-value < 0.001) (Fig. 3).…”