Drug–drug interactions (DDI) are a critical aspect
of drug
research that can have adverse effects on patients and can lead to
serious consequences. Predicting these events accurately can significantly
improve clinicians’ ability to make better decisions and establish
optimal treatment regimens. However, manually detecting these interactions
is time-consuming and labor-intensive. Utilizing the advancements
in Artificial Intelligence (AI) is essential for achieving accurate
forecasts of DDIs. In this review, DDI prediction tasks are classified
into three types according to the type of DDI prediction: undirected
DDI prediction, DDI events prediction, and Asymmetric DDI prediction.
The paper then reviews the progress of AI for each of these three
prediction tasks in DDI and provides a summary of the data sets used
as well as the representative methods used in these three prediction
directions. In this review, we aim to provide a comprehensive overview
of drug interaction prediction. The first section introduces commonly
used databases and presents an overview of current research advancements
and techniques across three domains of DDI. Additionally, we introduce
classical machine learning techniques for predicting undirected drug
interactions and provide a timeline for the progression of the predicted
drug interaction events. At last, we debate the difficulties and prospects
of AI approaches at predicting DDI, emphasizing their potential for
improving clinical decision-making and patient outcomes.