Collaborative modification strategy to develop a highly selective fluorescent probe for human UDP-glucuronosyltransferase 1A10

Zhai, Xin-Fang; Fan, Jianqing; Yang, Yi; Zhang, Meng; Yuan, Xiaocong; Qiao, Xue; Liu, Liang; Ye, Min

doi:10.1016/j.cej.2023.142382

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…This process plays an important role in the metabolic clearance of clinical drugs in vivo. [37][38][39][40] In addition, using glucosyltransferases (GTs) to achieve glycosylation has become an emerging method for industrial glycoside production. 41 Ma et al developed probe 12 for the real-time monitoring of glucoside transfer (Fig.…”

Section: Biocatalytic Glucoside Transfermentioning

confidence: 99%

Visual monitoring of biocatalytic processes using small molecular fluorescent probes: strategies-mechanisms-applications

Chen,

Xu,

et al. 2024

Chem. Commun.

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Section: Biocatalytic Glucoside Transfermentioning

confidence: 99%

Visual monitoring of biocatalytic processes using small molecular fluorescent probes: strategies-mechanisms-applications

Chen,

Xu,

et al. 2024

Chem. Commun.

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Fluorogenic Probes for Functional Imaging of Endoplasmic Reticulum‐Resident Proteins: from Molecular Engineering to Biomedical Applications

Fan,

Zhang,

Hao

et al. 2024

Adv Funct Materials

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Endoplasmic reticulum‐resident proteins (ERPs) are crucial for maintaining cellular homeostasis and are tightly associated with the onset and progression of various diseases. The emergence of fluorogenic probes responsive to ERPs has enabled scientists to in situ monitor the spatial distribution and function status of target ERPs in real‐time, which is very helpful for elucidating ERP‐related pathological mechanisms and developing innovative therapeutics. Over the past decade, a range of fluorogenic probes for sensing and imaging ERPs, including ion channels, oxidases, hydrolases, and transferases, have been devised. This review systematically summarizes the recent advances in molecular engineering and biomedical applications of ERP fluorogenic probes. Engineering strategies for constructing ERP‐activatable probes, along with their structural features, recognition fragments, and sensing performances, are discussed. Meanwhile, biomedical applications of these probes in biomarker analysis, disease treatment, multimodal imaging, and drug discovery are also highlighted. Finally, a forward‐looking perspective on the future directions and underlying challenges is explored. The insights and knowledge presented here will spur further innovation and technological breakthroughs in developing multifunctional ERP probes, advancing disease diagnosis, ER biology, and drug discovery.

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Fluorescent Chemo sensor nano-materials for Cancer bio-markers signalling: Towards development of non-invasive early detection strategies

Mbugua

2023

Dyes and Pigments

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Collaborative modification strategy to develop a highly selective fluorescent probe for human UDP-glucuronosyltransferase 1A10

Cited by 3 publications

References 34 publications

Visual monitoring of biocatalytic processes using small molecular fluorescent probes: strategies-mechanisms-applications

Visual monitoring of biocatalytic processes using small molecular fluorescent probes: strategies-mechanisms-applications

Fluorogenic Probes for Functional Imaging of Endoplasmic Reticulum‐Resident Proteins: from Molecular Engineering to Biomedical Applications

Fluorescent Chemo sensor nano-materials for Cancer bio-markers signalling: Towards development of non-invasive early detection strategies

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