Collaborative work on evaluation of ovarian toxicity 5) Two- or four-week repeated-dose studies and fertility study of busulfan in female rats

Sakurada, Yosuke; Kudo, Satoshi; Iwasaki, Shogo; Miyata, Yuki; Nishi, Miyuki; Masumoto, Yoshihiro

doi:10.2131/jts.34.s65

Cited by 14 publications

(6 citation statements)

References 19 publications

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“…dose of 10 mg/kg busulfan in SECXC57BL F1 mice induced eventual depletion of all follicles [89]. Sprague-Dawley rats dosed orally with busulfan for 4 wk had decreased numbers of embryos and preantral follicles at 0.5 and 1.5 mg/kg per day, respectively [90]. In FVB/NJNarl mice, 36 mg/kg busulfan i.p.…”

Section: Ionizing Radiation and Chemotherapeutic Agentsmentioning

confidence: 99%

Xenobiotic Effects on Ovarian Preantral Follicles1

Mark-Kappeler

Hoyer

Devine

2011

Biology of Reproduction

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Women are born with a finite population of ovarian follicles, which are slowly depleted during their reproductive years until reproductive failure (menopause) occurs. The rate of loss of primordial follicles is determined by genetic and environmental influences, but certain toxic exposures can accelerate this process. Ionizing radiation reduces preantral follicle numbers in rodents and humans in a dose-dependent manner. Cigarette smoking is linked to menopause occurring 1-4 yr earlier than with nonsmokers, and components of smoke, polycyclic aromatic hydrocarbons, can cause follicle depletion in rodents or in ovaries in vitro. Chemotherapeutic agents, such as alkylating drugs and cisplatin, also cause loss of preantral ovarian follicles. Effects depend on dose, type, and reactivity of the drug, and the age of the individual. Evidence suggests DNA damage may underlie follicle loss induced by one common alkylating drug, cyclophosphamide. Occupational exposures have also been linked to ovarian damage. In an industrial setting, 2-bromopropane caused infertility in men and women, and it can induce ovarian follicle depletion in rats. Solvents, such as butadiene, 4-vinylcyclohexene, and their diepoxides, can also cause specific preantral follicle depletion. The mechanism(s) underlying effects of the latter compound may involve alterations in apoptosis, survival factors such as KIT/Kit Ligand, and/or the cellular signaling that maintains primordial follicle dormancy. Estrogenic endocrine disruptors may alter follicle formation/development and impair fertility or normal development of offspring. Thus, specific exposures are known or suspected of detrimentally impacting preantral ovarian follicles, leading to early ovarian failure.

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Section: Ionizing Radiation and Chemotherapeutic Agentsmentioning

confidence: 99%

Xenobiotic Effects on Ovarian Preantral Follicles1

Mark-Kappeler

Hoyer

Devine

2011

Biology of Reproduction

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“… 12 Bolon et al (1997), 79 Hoyer (2004), 83 Ito et al (2009), 90 Kao et al (1999), 100 Kodama et al (2009), 149 Nozaki et al (2009), 162 Regan et al (2005), 166 Sakurada et al (2009)…”

Section: Morphologymentioning

confidence: 99%

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Alison²,

et al. 2014

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the female reproductive tract of laboratory rats and mice, with color photomicrographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. There is also a section on normal cyclical changes observed in the ovary, uterus, cervix and vagina to compare normal physiological changes with pathological lesions. A widely accepted and utilized international harmonization of nomenclature for female reproductive tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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“…Accumulating evidence suggests that the chemotherapy can cause long-term detrimental effects, including rendering the recipient sterile789. The transient sterilizing dose of B/C for male subjects is species-specific, with different required doses in mg/kg body weight reported for rodents1011, pigs11, and coyotes12.…”

mentioning

confidence: 99%

Intraovarian transplantation of primordial follicles fails to rescue chemotherapy injured ovaries

Park

Choi

Kwon

et al. 2013

Sci Rep

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Busulfan and cyclophosphamide (B/C)-treated mice exhibited a marked increase in apoptosis and a concomitant decrease in the ovarian weight. Histological and RT-PCR analysis indicate that the period of germ cell depletion in the B/C-treated ovaries coincides with decreased expression of genes Figla, Lhx8, Nobox, c-kit, and Sox3. However, depletion of the ovarian germ cells is mediated by autophagy-independent pathways that involve Fas/FasL-, TNF-, and/or p53-signalings. Treatment with B/C resulted in the cease of the reproductive function to produce their offspring during the 15th week post-treatment period in female mice. Furthermore, injection of the 3 × 106 GFP positive primordial follicles into the ovaries of the B/C treated mouse did not show apparent colonization of the transplanted follicles within the recipient ovaries. The present results suggest that B/C treatment is closely associated with an increased risk of premature ovarian failure.

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Collaborative work on evaluation of ovarian toxicity 5) Two- or four-week repeated-dose studies and fertility study of busulfan in female rats

Cited by 14 publications

References 19 publications

Xenobiotic Effects on Ovarian Preantral Follicles1

Xenobiotic Effects on Ovarian Preantral Follicles1

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Intraovarian transplantation of primordial follicles fails to rescue chemotherapy injured ovaries

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