Collagen 1 signaling at the central nervous system injury site and astrogliosis

Neo, Sin Hui; Tang, Bor Luen

doi:10.4103/1673-5374.217323

Cited by 11 publications

(3 citation statements)

References 12 publications

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“…In the healthy CNS, fibril-forming collagens are present in the vessel structure and in meningeal membranes, while non-fibril-forming collagen proteins are widely distributed throughout the CNS, where they play a major role in CNS wiring and repair [ 34 , 35 ]. Although collagen IV is the most widely studied component of the fibrous scar tissue which develops after CNS injury [ 36 ], an up-regulation of collagen 1is also seen as an activator of astrocytes, driving them to a scar-forming phenotype [ 37 ]. Interestingly, Col1a1-positive cells have recently been identified as perivascular stromal cells activated following brain and spinal cord injuries, participating in fibrosis scar formation and secreting retinoic acid and other fundamental signaling molecules [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Time-Course Changes of Extracellular Matrix Encoding Genes Expression Level in the Spinal Cord Following Contusion Injury—A Data-Driven Approach

Bighinati

Khalajzeyqami

Baldassarro

et al. 2021

IJMS

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The involvement of the extracellular matrix (ECM) in lesion evolution and functional outcome is well recognized in spinal cord injury. Most attention has been dedicated to the “core” area of the lesion and scar formation, while only scattered reports consider ECM modification based on the temporal evolution and the segments adjacent to the lesion. In this study, we investigated the expression profile of 100 genes encoding for ECM proteins at 1, 8 and 45 days post-injury, in the spinal cord segments rostral and caudal to the lesion and in the scar segment, in a rat model. During both the active lesion phases and the lesion stabilization, we observed an asymmetric gene expression induced by the injury, with a higher regulation in the rostral segment of genes involved in ECM remodeling, adhesion and cell migration. Using bioinformatic approaches, the metalloproteases inhibitor Timp1 and the hyaluronan receptor Cd44 emerged as the hub genes at all post-lesion times. Results from the bioinformatic gene expression analysis were then confirmed at protein level by tissue analysis and by cell culture using primary astrocytes. These results indicated that ECM regulation also takes place outside of the lesion area in spinal cord injury.

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Section: Discussionmentioning

confidence: 99%

Time-Course Changes of Extracellular Matrix Encoding Genes Expression Level in the Spinal Cord Following Contusion Injury—A Data-Driven Approach

Bighinati

Khalajzeyqami

Baldassarro

et al. 2021

IJMS

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“…[ By linking immunological responses related to meningothelial cells and chondrocytes as the secretors of collagen 3 , the present study has reported and concluded that collagen I level is decreased in Iraqi meningioma patients ( Table (1) ) caused by defects in immune system reflected by meningothelial cells and mediated by the activity of chondrocytes which responsible for collagenase 3 biosynthesis, Figure (1). The biochemical role of collagen I in astrogliosis is pivotal, by protecting astrocytes from an expression of cell adhesion molecules and also by activating and driving astrocytes toward neuronal regeneration after injury (13) .According to astrocytes , a recent study has shown that microglia/astrocyte tumor interactions are highlighted in brain tumors and mediated by a number of factors but the exact mechanism was not understood (15) .Regarding magnesium, a recent study has shown that magnesium sulfate was given as a drug ( treatment ) to meningioma patients but the details were not highlighted . Remarkably, this study may give a hint to magnesium deficiency in meningioma patients without any absolute indicator (16) .In contrast, the present results disagree with a very old study which has found that magnesium level was significantly increased in sera of eight meningioma patients compared with normal subjects (17) .Additionally, a previous study has indicated a cellular response of chondrocytes to magnesium alloys (18) .…”

Section: ))mentioning

confidence: 56%

“…Moreover, collagen types are bound with integrin. Hence, integrin subtypes are all existed in astrocytes (13) .Collagen I is degraded by a specific enzyme called collagenase 3 , it is a sub-type of collagenases which compromise a large family of reactive proteolytic enzymes (3) .Collagenase 3 is mainly expressed , biosynthesized by humen chondrocytes, it has been suggested that collagenase 3 is not present in normal tissues but identified in some carcinomas tissues such as breast. Moreover , it has been reported that collagenase 3 gene in normal tissues is expressed at very minimal levels while its expression may be stimulated under physiological conditions (14) .In this regard, meningothelial (arachnoid) cells play a crucial role in immunological responses via secretion of pro and anti-inflammatory cytokines signaling as immunomodulator factors.…”

Section: ))mentioning

confidence: 99%

The Role of Collagen I, Magnesium and Phosphorus in Iraqi Meningioma Patients

Rasha Zuhair Jasim

2024

IJPS

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Meningiomas are the most common primary intracellular slow growing benign tumor that are mostly arisen from meningeothelial (arachnoid) cells which surround the brain and the spinal cord. The aim of the present study is to innovate a biochemical relationship between collagen I and meningiomas in Iraqi patients and also to examine the biochemical role of magnesium and phosphorus regarding this complex nervous disease. Thirty (30) diagnosed meningioma patients were participated in the present study and were classified into two (2) groups : G3 composed of (15) newly diagnosed meningioma males and G4 composed of (15) newly diagnosed meningioma females , both G3 and G4 subjects did not take any treatment linked with meningioma or any chronic disease. Patients groups were compared with healthy subjects as two control groups which did not suffer from any chronic disease , the first G1 composed of (15) healthy males and the second G2 composed of (15) healthy females in the range of age matched with patients groups. Blood samples were collected from each subject enrolled in this study and three biochemical parameters (collagen I , magnesium , phosphorus ) were determined in sera of all groups. Results of the present study have reported that levels of collagen I , magnesium and phosphorus were highly significant decreased in sera of G3 and G4 compared with G1 and G2 respectively , while the difference between G3 and G4 was non significant for the three biochemical parameters. The present study has contributed to collagen I novelty regarding Iraqi patients with meningiomas deficiency and also highlighted the biochemical role of both magnesium and phosphorus in accordance with meningiomas. The present study recommends checking periodically the levels of collagen I , magnesium and phosphorous by laboratory tests and treatment with collagen supplements tablets and metabolics ( magnesium phosphate ) capsules if a deficeicy has been noticed. .………………

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Extracellular Matrix‐Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin‐Like Polypeptide Hydrogels

Gilbert

2021

Adv Healthcare Materials

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Neurological and functional recovery is limited following central nervous system injury and severe injury to the peripheral nervous system. Extracellular matrix (ECM)-mimetic hydrogels are of particular interest as regenerative scaffolds for the injured nervous system as they provide 3D bioactive interfaces that modulate cellular response to the injury environment and provide naturally degradable scaffolding for effective tissue remodeling. In this review, three unique ECM-mimetic hydrogels used in models of neural injury are reviewed: fibrin hydrogels, which rely on a naturally occurring enzymatic gelation, hyaluronic acid hydrogels, which require chemical modification prior to chemical crosslinking, and elastin-like polypeptide (ELP) hydrogels, which exhibit a temperature-sensitive gelation. The hydrogels are reviewed by summarizing their unique biological properties, their use as drug depots, and their combination with other biomaterials, such as electrospun fibers and nanoparticles. This review is the first to focus on these three ECM-mimetic hydrogels for their use in neural tissue engineering. Additionally, this is the first review to summarize the use of ELP hydrogels for nervous system applications. ECM-mimetic hydrogels have shown great promise in preclinical models of neural injury and future advancements in their design and use can likely lead to viable treatments for patients with neural injury.

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Collagen 1 signaling at the central nervous system injury site and astrogliosis

Cited by 11 publications

References 12 publications

Time-Course Changes of Extracellular Matrix Encoding Genes Expression Level in the Spinal Cord Following Contusion Injury—A Data-Driven Approach

Time-Course Changes of Extracellular Matrix Encoding Genes Expression Level in the Spinal Cord Following Contusion Injury—A Data-Driven Approach

The Role of Collagen I, Magnesium and Phosphorus in Iraqi Meningioma Patients

Extracellular Matrix‐Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin‐Like Polypeptide Hydrogels

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