Collagen: A review on its sources and potential cosmetic applications

Rodríguez, María Isabela Avila; Barroso, Laura G Rodríguez; Sánchez, María Amparo

doi:10.1111/jocd.12450

Cited by 410 publications

(257 citation statements)

References 39 publications

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“…Several brands and formulas with different quality and at different prices can be purchased. The global market of collagen hydrolysates was valuated at USD 3.71 billion in 2016 and it is expected to reach USD 6.63 billion by 2025 (Avila Rodriguez, Rodriguez Barroso, & Sanchez, 2018). Since the use of these products is intended to obtain health benefits, their quality must be guaranteed (Sarma, Giancaspro, & Venema, 2016).…”

Section: Food Chemistrymentioning

confidence: 99%

Determination of Peptide Profile Consistency and Safety of Collagen Hydrolysates as Quality Attributes

López‐Morales

Vázquez-Leyva

Vallejo-Castillo

et al. 2019

Journal of Food Science

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Collagen hydrolysates are dietary supplements used for nutritional and medical purposes. They are complex mixtures of low‐molecular‐weight peptides obtained from the enzymatic hydrolysis of collagen, which provide intrinsic batch‐to‐batch heterogeneity. In consequence, the quality of these products, which is related to the reproducibility of their mass distribution pattern, should be addressed. Here, we propose an analytical approach to determine the peptide pattern as a quality attribute of Colagenart®, a product containing collagen hydrolysate. In addition, we evaluated the safety by measuring the viability of two cell lines exposed to the product. The consistency of peptide distribution was determined using Size Exclusion Chromatography (SEC), Mass Spectrometry coupled to a reversed phase UPLC system (MS‐RP‐UPLC), and Shaped‐pulse off‐resonance water‐presaturation proton nuclear magnetic resonance spectrometry [ 1 Hwater_presat NMR]. The mass distribution pattern determined by SEC was in a range from 1.35 to 17 kDa, and from 2 to 14 kDa by MS‐RP‐UPLC. [ 1 Hwater_presat NMR] showed the detailed spin‐systems of the collagen hydrolysates components by global assignment of backbone Hα and NH, as well as side‐chain proton resonances. Additionally, short‐range intraresidue connectivity pathways of identified spin‐regions were obtained by a 2D homonuclear shift correlation Shaped‐pulse solvent suppression COSY scheme. Safety analysis of Colagenart® was evaluated in CaCo‐2 and HepG2 cells at 2.5 and 25 μg/mL and no negative effects were observed. The results demonstrated batch‐to‐batch reproducibility, which evinces the utility of this approach to establish the consistency of the quality attributes of collagen hydrolysates. Practical Application We propose state‐of‐the art analytical methodologies (SEC, MS, and NMR) to evaluate peptide profile and composition of collagen hydrolysates as quality attributes. These methodologies are suitable to be implemented for quality control purposes.

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Section: Food Chemistrymentioning

confidence: 99%

Determination of Peptide Profile Consistency and Safety of Collagen Hydrolysates as Quality Attributes

López‐Morales

Vázquez-Leyva

Vallejo-Castillo

et al. 2019

Journal of Food Science

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“…Hence, there is an urgent need to find novel alternative sources of collagen.Recently, marine organisms have received consideration as promising sources of collagen, because they have no limitations in use for any religions and there are no reports of possible transmissible diseases. In particular, biomass derived from the activities of fish-processing industries and fisheries (fish and sea urchin wastes, undersized fish and by-catch organisms such as jellyfish, sharks, starfish, sponges) might become an important, yet underexploited, source of collagen [9][10][11][12][13][14]. The use of discarded and underused biomass will contribute to the development of a sustainable pipeline to obtain collagen with a significantly reduced environmental impact.In this review, we present a general overview of the studies carried out on by-catch organisms and wastes from fish and sea urchin processing industries in order to isolate collagen.…”

mentioning

confidence: 99%

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

et al. 2020

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Due to its unique properties, collagen is used in the growing fields of pharmaceutical and biomedical devices, as well as in the fields of nutraceuticals, cosmeceuticals, food and beverages. Collagen also represents a valid resource for bioplastics and biomaterials, to be used in the emerging health sectors. Recently, marine organisms have been considered as promising sources of collagen, because they do not harbor transmissible disease. In particular, fish biomass as well as by-catch organisms, such as undersized fish, jellyfish, sharks, starfish, and sponges, possess a very high collagen content. The use of discarded and underused biomass could contribute to the development of a sustainable process for collagen extraction, with a significantly reduced environmental impact. This addresses the European zero-waste strategy, which supports all three generally accepted goals of sustainability: sustainable economic well-being, environmental protection, and social well-being. A zero-waste strategy would use far fewer new raw materials and send no waste materials to landfills. In this review, we present an overview of the studies carried out on collagen obtained from by-catch organisms and fish wastes. Additionally, we discuss novel technologies based on thermoplastic processes that could be applied, likewise, as marine collagen treatment.2 of 23 protective colloid functions and film-forming capacity. Also, collagen is a good surface-active agent, with its ability to penetrate lipid-free interfaces [2].Collagen can be utilized in a variety of applications because of its biocompatibility and excellent degradability [3,4]. Furthermore, it is known that collagen is a molecule with weak immunogenicity, which decreases the possibilities of rejection when it is ingested or injected into a different body. Although this molecule has already low antigenicity, this property can be enhanced by modifying it to suppress any immune response [5,6]. Additionally, collagen peptides and gelatin (denatured collagen) have been widely utilized in different fields such as food, medicine, cosmetics, leather and film industries, diagnostic imaging, and therapeutic delivery [7].For many years, most available collagen was extracted from discards from the bovine and porcine processing industries, but during the last few decades the use of collagen from these sources has been limited. The use of porcine and bovine-derived products is occasionally prevented by dietary regimes, due to specific needs or personal choices. It is forbidden by religious constraints, to Muslims, Hindus and Jews who make up 38.4% of the global population [8]. Moreover, the use of bovine-derived products became a concern for a wider section of the population during the bovine spongiform encephalopathy (BSE), transmissible spongiform encephalopathy (TSE) and foot-and-mouth disease (FMD) crises that occurred over the last few decades in all areas of the world, mostly in the United Kingdom and Asia. Bovine-derived products might be a vehicle of transmission of these diseases ...

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“…Many of the physical and chemical properties of these compounds are related to the environmental conditions such as pH, type of microorganism, and neighboring components; and its structural characteristics such as molecular weight (MW), degree of deacetylation, derivative form, its concentration, and original source (Hosseinnejad and Jafari, 2016). Herein, pH, MW, and degree of deacetylation together provide an excellent estimation of the charge density (Avila Rodríguez et al, 2018). Possible and accepted antimicrobial mechanisms for chitosan have been reported in the existing literature (Agullo et al, 2003;Goy et al, 2009).…”

Section: Antimicrobial Agentmentioning

confidence: 99%

Utilization of marine by-products for the recovery of value-added products

Shahidi¹,

Varatharajan²,

Han³

et al. 2019

Journal of Food Bioactives

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The world fisheries resources have exceeded 160 million tons in recent years. However, every year a considerable amount of total catch is discarded as by-catch or as processing leftovers, and that includes trimmings, fins, frames, heads, skin, viscera and among others. In addition, a large quantity of processing by-products is accumulated as shells of crustaceans and shellfish from marine bioprocessing plants. Recognition of the limited marine resources and the increasing environmental pollution has emphasized the need for better utilization of the by-products. Marine by-products contain valuable protein and lipid fractions, minerals, enzymes as well as many other components. The major fraction of by-products are used for feed production-in making fish meal/oil, but this has low profitability. However, there are many ways in which the fish and shellfish waste could be better utilized, including the production of novel food ingredients, nutraceuticals, pharmaceuticals, biomedical materials, fine chemicals, and other value-added products. In recent times, much research is conducted in order to explore the possible uses of different by-products. This contribution primarily covers the characteristics and utilization of the main ingredients such as protein, lipid, chitin and its derivatives, enzymes, carotenoids, and minerals originating from marine by-products.

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Collagen: A review on its sources and potential cosmetic applications

Cited by 410 publications

References 39 publications

Determination of Peptide Profile Consistency and Safety of Collagen Hydrolysates as Quality Attributes

Determination of Peptide Profile Consistency and Safety of Collagen Hydrolysates as Quality Attributes

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

Utilization of marine by-products for the recovery of value-added products

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