Collagen and Elastin in the Obstructed Fetal Bladder

Kim, Kwang M.; Kogan, Barry A.; Massad, Charlotte A.; Huang, Yi-C.

doi:10.1016/s0022-5347(17)37844-8

Cited by 99 publications

(40 citation statements)

References 16 publications

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“…However, there is a growing body of evidence that suggests that an abnormal accumulation and distribution of connective tissue within the bladder wall may significantly decrease bladder compliance. Previous studies have demonstrated significant changes in the collagen content of dysfunctional bladders [Giplin et al, 1985;Shapiro et al, 1991;Ewalt et al, 1992;Deveaud et al, 1998;Kim et al, 1991;Gosling and Dixon, 1980;Levy and Wight, 1990;Workman and Kogan, 1990;Ghoniem et al, 1984Ghoniem et al, , 1989Cortivo et al, 1981]. Fibrotic areas within the detrusor muscle bundles of noncompliant bladders are characteristically infiltrated by collagen and elastin, as observed by light and electron microscopy [Shapiro et al, 1991;Cortivo et al, 1981].…”

Section: Introductionmentioning

confidence: 94%

Role of type III collagen in bladder filling

et al. 1998

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Section: Introductionmentioning

confidence: 94%

Role of type III collagen in bladder filling

et al. 1998

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“…5 Kim et al reported increased muscle thickness but with decreased collagen relative to muscle. 6 Workman and Kogan also found increased muscle thickness in human fetal bladders with posterior urethral valves, although in contrast to previous findings, there was a disproportionate increase in connective tissue. 7 However, few studies have examined the pathophysiology of the fetal detrusor muscle exposed to bladder outflow obstruction.…”

Section: Introductionmentioning

confidence: 53%

Ca ²⁺ Regulation in Detrusor Smooth Muscle From Ovine Fetal Bladder After In Utero Bladder Outflow Obstruction

Thiruchelvam

Sui

et al. 2007

Journal of Urology

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] i to purinergic neurotransmitter ATP was also found to be smaller in cells from obstructed bladders (p<0.05), although trans-membrane influx by high K depolarization was not significantly affected. Conclusions:Muscarinic and purinergic pathways were down-regulated in fetal detrusor muscle following outflow obstruction. These major functional receptors appeared to be more susceptible to obstruction than other Ca 2+ regulators and their impairment may contribute to compromised contractile function seen with in utero BOO.3

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“…Based on ovine modeling, it appears that shunting defunctionalizes the bladder by disrupting the cyclical filling and emptying process, which is critical for normal bladder development [16,17] . Other evidence points to the initial obstructive insult as the etiology behind the histological and functional differences in the bladder, with detrusor muscle hypertrophy, increased connective tissue deposition and changes in collagen and elastin profiles [18,19] . Other potential pitfalls from shunting include the risk for shunt dislodgement or obstruction [20] .…”

Section: Discussionmentioning

confidence: 99%

Fetoscopic Transuterine Release of Posterior Urethral Valves: A New Technique

Clifton

Harrison²,

Ball³

et al. 2007

Fetal Diagn Ther

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Fetal urinary tract obstruction with oligohydramnios produces pulmonary hypoplasia and renal dysplasia. Decompression of the obstructed urinary tract may restore amniotic fluid and allow lung growth, but transabdominal catheter shunt decompression is often inadequate and does not allow for cycling of the bladder, while open procedures cause significant maternal morbidity. Disruption of the anatomic obstruction, usually posterior urethral valves in a male fetus, would be ideal but has proven technically difficult. Here we describe a new technique of percutaneous fetal cystoscopy and disruption of posterior urethral valves, and the case report of our first application of this technique. We pre-sent a case of a 17-week male fetus with posterior urethral valves which underwent fetal cystoscopy for mechanical disruption of posterior urethral valves. This minimally invasive approach to disruption of posterior urethral valves in a fetus is a novel method for decompressing the urinary tract. The technique offers a minimal degree of maternal morbidity and, if instituted early enough, can restore amniotic fluid volume, avert fatal pulmonary hypoplasia and may preserve renal function.

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Collagen and Elastin in the Obstructed Fetal Bladder

Cited by 99 publications

References 16 publications

Role of type III collagen in bladder filling

Role of type III collagen in bladder filling

Ca ²⁺ Regulation in Detrusor Smooth Muscle From Ovine Fetal Bladder After In Utero Bladder Outflow Obstruction

Fetoscopic Transuterine Release of Posterior Urethral Valves: A New Technique

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Collagen and Elastin in the Obstructed Fetal Bladder

Cited by 99 publications

References 16 publications

Role of type III collagen in bladder filling

Role of type III collagen in bladder filling

Ca 2+ Regulation in Detrusor Smooth Muscle From Ovine Fetal Bladder After In Utero Bladder Outflow Obstruction

Fetoscopic Transuterine Release of Posterior Urethral Valves: A New Technique

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Ca ²⁺ Regulation in Detrusor Smooth Muscle From Ovine Fetal Bladder After In Utero Bladder Outflow Obstruction