Collagen- and hyaluronic acid-based hydrogels and their biomedical applications

Xu, Qinghua; Torres, Jessica E.; Hakim, Mazin H.; Babiak, Paulina M.; Pal, Pallabi; Battistoni, Carly M.; Nguyen, Michael; Panitch, Alyssa; Solorio, Luis; Liu, Julie C.

doi:10.1016/j.mser.2021.100641

Cited by 154 publications

(114 citation statements)

References 732 publications

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“…Owing to the unique merits of biocompatibility, biodegradability, and environmental friendliness, hydrogels are often used in biomedical and implantable applications. [139][140][141] The advent of flexible TENGs makes it possible to be applied in similar applications, such as in vivo heartbeat monitoring, [142] drug delivery, [143,144] tissue regeneration, [51] and muscle stimulation. [145] Therefore, a few researchers have also considered H-TENGs into biomedical and implantable applications.…”

Section: Biomedical/implantable Electronicsmentioning

confidence: 99%

Hydrogels as Soft Ionic Conductors in Flexible and Wearable Triboelectric Nanogenerators

Luo

Cuthbert

et al. 2022

Advanced Science

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Flexible triboelectric nanogenerators (TENGs) have attracted increasing interest since their advent in 2012. In comparison with other flexible electrodes, hydrogels possess transparency, stretchability, biocompatibility, and tunable ionic conductivity, which together provide great potential as current collectors in TENGs for wearable applications. The development of hydrogel-based TENGs (H-TENGs) is currently a burgeoning field but research efforts have lagged behind those of other common flexible TENGs. In order to spur research and development of this important area, a comprehensive review that summarizes recent advances and challenges of H-TENGs will be very useful to researchers and engineers in this emerging field. Herein, the advantages and types of hydrogels as soft ionic conductors in TENGs are presented, followed by detailed descriptions of the advanced functions, enhanced output performance, as well as flexible and wearable applications of H-TENGs. Finally, the challenges and prospects of H-TENGs are discussed.

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Section: Biomedical/implantable Electronicsmentioning

confidence: 99%

Hydrogels as Soft Ionic Conductors in Flexible and Wearable Triboelectric Nanogenerators

Luo

Cuthbert

et al. 2022

Advanced Science

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“…Other collagens and collagen-like proteins Collagen extraction protocols consist of four general steps: [4,18,19] • raw material separation and size reduction (squares of ͠ 1.5 ×1.5 cm). • removal of non-collagenous components (sodium hydroxide (NaOH), hydrogen peroxide (H 2 O 2 ), calcium hydroxide (Ca(OH) 2 ), or a combination of these).…”

Section: Collagen's Superfamily and Structurementioning

confidence: 99%

Collagen Biopolymer in Textile Wet Processing

Hassabo

Othman

Bakr

et al. 2022

J.Text.color. pol. sci.

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C ollagen is the most abundant protein in the animal kingdom and is a key component of the extracellular matrix (ECM). Collagen is produced from both natural and synthetic resources. Natural resources are the best resources. Collagen has attracted wide attention in several fields due to its abundance, low cost, and exciting physical and chemical properties, especially, biocompatibility and biodegradability. However, collagen suffers from weak physical and chemical characteristics (mechanical strength, thermostability and resistance to enzyme). As a result, collagen must be modified throughout the processing process. collagen is an ecofriendly resource that can be used to produce multifunctional, recyclable, biocompatible, and biodegradable materials that are ideal for new technologies in materials science, biomedicine, and environmental remediation.

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“…This is avoided in the physically crosslinked gels. The incorporation of other ECM components can also be used to enhance the mechanical integrity of ECM hydrogels such as network formation between individual ECM components (i.e., collagen/fibrin [41,42], fibrin/HA [43], collagen/chondroitin sulfate/ hyaluronic acid (HA)) [44]. The incorporation of ECM components has not only been shown to enhance mechanical integrity, but it also modulates cellular behavior such as in the upregulation of tissue specific gene expression and ECM molecule secretion [43][44][45].…”

Section: Ecm-based Biomaterialsmentioning

confidence: 99%

Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering

Khanna

Zamani

Huang

2021

JCDD

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Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tissue-engineered replacements. The extracellular matrix (ECM) is a dynamic scaffolding structure characterized by tissue-specific biochemical, biophysical, and mechanical properties that modulates cellular behavior and activates highly regulated signaling pathways. In light of technological advancements, biomaterial-based scaffolds have been developed that better mimic physiological ECM properties, provide signaling cues that modulate cellular behavior, and form functional tissues and organs. In this review, we summarize the in vitro, pre-clinical, and clinical research models that have been employed in the design of ECM-based biomaterials for cardiovascular regenerative medicine. We highlight the research advancements in the incorporation of ECM components into biomaterial-based scaffolds, the engineering of increasingly complex structures using biofabrication and spatial patterning techniques, the regulation of ECMs on vascular differentiation and function, and the translation of ECM-based scaffolds for vascular graft applications. Finally, we discuss the challenges, future perspectives, and directions in the design of next-generation ECM-based biomaterials for cardiovascular tissue engineering and clinical translation.

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Collagen- and hyaluronic acid-based hydrogels and their biomedical applications

Cited by 154 publications

References 732 publications

Hydrogels as Soft Ionic Conductors in Flexible and Wearable Triboelectric Nanogenerators

Hydrogels as Soft Ionic Conductors in Flexible and Wearable Triboelectric Nanogenerators

Collagen Biopolymer in Textile Wet Processing

Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering

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