Collagen and hyaluronic acid hydrogel in water-in-oil microemulsion delivery systems

Kupper, Sylwia; Kłosowska-Chomiczewska, Ilona; Szumała, Patrycja

doi:10.1016/j.carbpol.2017.08.010

Cited by 52 publications

(34 citation statements)

References 35 publications

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“…For drug deposition in bladder tissue, it was found that dual-microemulsions with or without polymer could increase deposition amounts of gemcitabine and cisplatin, showing that microemulsions could significantly enhance the permeability of hydrophilic and hydrophobic drugs. The results are consistent with the above in vitro penetration results, indicating that nanoparticles can promote the permeability of chemotherapeutic drugs into the urothelium [ 17 , 19 , 20 ]. In scheme 1 (0 h after 1 h incubation), the deposition amount of gemcitabine and cisplatin of the formulation without polymer was higher than that of the formulation with polymer, indicating that the diffusion rates of gemcitabine and cisplatin decreased via increasing the viscosity of formulations.…”

Section: Resultssupporting

confidence: 89%

“…Extending the retention time in the bladder and improving the permeability of chemotherapeutic drugs into the urothelium are important tasks for effective intravesical administration. In the past few decades, nanoparticles have been developed to improve the permeability [ 17 , 18 , 19 , 20 , 21 ]. Hydrogels have been used to prolong the retention time of the load in the bladder and sustainably release drug(s) to enhance local drug concentration at disease sites [ 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…Their viscosities are low and droplet sizes are in the submicron range. As drug delivery carriers, they offer high drug solubilizing capacity, ease of preparation, long-term stability, and capability to increase permeability for hydrophobic and hydrophilic drugs [ 17 , 19 , 26 , 27 ]. In this study, a viscous microemulsion was used as a drug delivery carrier to simultaneously increase the penetration efficiency of gemcitabine and cisplatin into the bladder endothelial tissue.…”

Section: Introductionmentioning

confidence: 99%

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Co-Delivery of Cisplatin and Gemcitabine via Viscous Nanoemulsion for Potential Synergistic Intravesical Chemotherapy

et al. 2020

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Combined chemotherapy is an effective and safe treatment for cancers. Co-administration of cisplatin and gemcitabine produces a synergistic effect for bladder cancer treatment, so viscous microemulsions were developed for co-delivery of cisplatin and gemcitabine to extend the retention time and improve the permeability of chemotherapeutic drugs into the urothelium by intravesical administration. Results showed that the deposition amounts of cisplatin and gemcitabine significantly increased in in vitro and in vivo study. The penetration depth in bladder tissue samples increased from 60 to 120 μm. The dual-loaded formulation also showed thermodynamic and chemical stability, demonstrating that these gel-based microemulsions are promising drug delivery carriers for chemotherapy agents by intravesical administration.

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Section: Resultssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Co-Delivery of Cisplatin and Gemcitabine via Viscous Nanoemulsion for Potential Synergistic Intravesical Chemotherapy

et al. 2020

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“…Numerous studies have proven that collagen derived from sea cucumbers also represents the type I collagen group. Kupper et al [ 160 ] investigated the application of collagen/hyaluronic acid-based microemulsions from sea cucumber Holothuria cinerascens as the transdermal carrier with the focus on anti-aging research products including anti-wrinkle creams. At this point, collagen derived from cold-water fish skin, including cod, haddock, and salmon are being widely used in the cosmetic industry [ 161 , 162 ].…”

Section: Industrial Applicationsmentioning

confidence: 99%

Sea Cucumber Derived Type I Collagen: A Comprehensive Review

2020

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Collagen is the major fibrillar protein in most living organisms. Among the different types of collagen, type I collagen is the most abundant one in tissues of marine invertebrates. Due to the health-related risk factors and religious constraints, use of mammalian derived collagen has been limited. This triggers the search for alternative sources of collagen for both food and non-food applications. In this regard, numerous studies have been conducted on maximizing the utilization of seafood processing by-products and address the need for collagen. However, less attention has been given to marine invertebrates and their by-products. The present review has focused on identifying sea cucumber as a potential source of collagen and discusses the general scope of collagen extraction, isolation, characterization, and physicochemical properties along with opportunities and challenges for utilizing marine-derived collagen.

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“…Por otra parte, vemos como en la membrana también se encuentra el ácido hialurónico (HA), perteneciente a la familia de los glicosaminoglicanos, el HA es un polisacárido lineal con disacáridos, ácido D-glucurónico y N-acetil-d-glucosamina, ubicado en la matriz extracelular. Presenta una alta polaridad, siendo un reservorio importante de agua en la dermis; lo que aporta elasticidad al tejido intracelular y participa en la fibrogénisis (28), es decir, que ambos componentes le confieren integralidad a la estructura de la piel (46).…”

Section: /11unclassified

Usos potenciales de la cáscara de huevo de gallina (Gallus gallus domesticus): una revisión sistemática

Bedoya-Salazar

Valencia-González

2020

Rev Colombiana Cienc Anim. RECIA

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El huevo de gallina (Gallus gallus domesticus) es uno de los alimentos de mayor consumo a nivel mundial y en el caso específico de Colombia. Según la Federación Nacional de Avicultores-(FENAVI), en el año 2018 el consumo per-capital fue de 293 unidades. Este consumo genera un elevado volumen de cáscara como residuo, lo que lleva a los investigadores a interesarse en su aprovechamiento en diversas áreas, propiciando el desarrollo de emprendimientos. Además, sería un aspecto bastante negativo para el impacto ambiental, debido al manejo inadecuado de los residuos ordinarios, como es el caso de la cáscara de huevo, convirtiéndose en un factor de riesgo para la sostenibilidad y la sustentabilidad ambiental. Esta revisión muestra estudios del aprovechamiento de la cáscara como residuo agroalimentario en diferentes áreas, tales como la industria farmacéutica, química, cosmética y alimentaria. Su alto contenido en carbonato de calcio y otros constituyentes minoritarios como hidróxido de calcio, carbonato de magnesio, fosfato de calcio, sustancias orgánicas y en su membrana proteínas como el colágeno y el ácido hialurónico, la hacen una materia prima única y polifuncional.

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Collagen and hyaluronic acid hydrogel in water-in-oil microemulsion delivery systems

Cited by 52 publications

References 35 publications

Co-Delivery of Cisplatin and Gemcitabine via Viscous Nanoemulsion for Potential Synergistic Intravesical Chemotherapy

Co-Delivery of Cisplatin and Gemcitabine via Viscous Nanoemulsion for Potential Synergistic Intravesical Chemotherapy

Sea Cucumber Derived Type I Collagen: A Comprehensive Review

Usos potenciales de la cáscara de huevo de gallina (Gallus gallus domesticus): una revisión sistemática

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