Collagen and hypertension

Deinum, J.

doi:10.1097/00004872-200207000-00008

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…In addition, collagen deposition in the cardiovascular system can increase stiffness and may also be influenced by hypertension. 24 , 25 , 26 , 27 We previously showed that extracellular matrix components have a distinct temporal pattern of expression in this model, 28 and there is significantly more and earlier collagen deposition in hypertensive mice compared with normotensive mice ( Fig 4 ), consistent with a negative influence on venous remodeling with hypertension. On the other hand, several studies have reported an association of hypertension with higher rates of successful AVF maturation.…”

Section: Discussionsupporting

confidence: 60%

A central arteriovenous fistula reduces systemic hypertension in a mouse model

Brahmandam,

Alves,

Liu

et al. 2024

JVS-Vascular Science

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Section: Discussionsupporting

confidence: 60%

A central arteriovenous fistula reduces systemic hypertension in a mouse model

Brahmandam,

Alves,

Liu

et al. 2024

JVS-Vascular Science

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“…Im Rahmen des "physiologischen" Alterns nimmt das Herzgewicht zu, der interstitielle Kollagengehalt ist erhöht und die Kalziumaufnahme in das sarkoplasmatische Retikulum ist verlängert [6]. Alterungsprozesse sind somit "Kofaktoren" der diastolischen Dysfunktion bei arterieller Hypertonie.…”

Section: Diastolische Herzinsuffizienzunclassified

Hochdruck und Herzinsuffizienz

2007

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Arterial hypertension is the leading cause of mortality and morbidity with a worldwide prevalence of 26%. Aging increases the incidence of arterial hypertension. Arterial hypertension is the prime example for a chronic disease with asymptomatic beginning, creeping course and fatal outcome. Arterial hypertension is a major cardiovascular risk factor and leads to vascular as well as myocardial manifestations: coronary artery disease, hypertensive microvascular disease, concentric left ventricular hypertrophy as well as perivascular and interstitial fibrosis. In the late stages of the disease, hypertrophy and cardiac failure develop. Arterial hypertension is the leading cause of coronary artery disease and cardiac failure, and coronary artery disease is the cause of heart failure in 50% of cases. Various non-invasive and invasive procedures are available for screening and follow-up. The primary therapeutic target is to reverse cardiac manifestations of arterial hypertension using specific therapeutic algorithms as well as lowering blood pressure. This article covers the pathophysiology of arterial hypertension and cardiac failure, clinical symptoms, diagnostic options and therapeutical goals as well as medicinal options.

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“…Von erheblicher Bedeutung ist des Weiteren eine immunhistologisch nachweisbare gesteigerte perivaskuläre und interstitielle Kollagenanreicherung [50]. Nach dem Laplace'schen Gesetz stellt die Wanddickenzunahme des Gefäßes, die im Fall von Blutdruckspitzen zu einer Reduktion der Wandspannung führt, bis zu einem gewissen Grad einen Kompensationsmechanismus dar [7]. Die Kombination von Mediahypertrophie und Kollageneinlagerung führt aber letztlich zu einer "Versteifung" des Gefäßes [49].…”

Section: Strukturelle Gefäß-und Myokardveränderungen Bei Hypertensiveunclassified

Hypertensive mikrovaskul�re Erkrankung

Schannwell

Steiner²,

Strauer

2005

Herz

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Arterial hypertension is a major cardiovascular risk factor and leads to vascular as well as to myocardial manifestations. Particularly hypertensive microvascular disease is of great importance. Major clinical manifestations of hypertensive heart disease are symptoms of coronary insufficiency with typical angina pectoris, but also heart failure (systolic or diastolic dysfunction) and arrhythmia. Different non-invasive and invasive procedures are available for screening. For ultimate quantitative assessment of the coronary reserve, invasive procedures are still required. Beside lowering blood pressure primary therapeutic target is to reverse cardiac manifestations of arterial hypertension using specific therapeutic algorithms.

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Collagen and hypertension

Cited by 5 publications

References 12 publications

A central arteriovenous fistula reduces systemic hypertension in a mouse model

A central arteriovenous fistula reduces systemic hypertension in a mouse model

Hochdruck und Herzinsuffizienz

Hypertensive mikrovaskul�re Erkrankung

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