Collagen arrangements in ureter

Dorrell, Paul; Wilkinson, Rosemary; Gorham, S. D.; Aitchison, Michael; Scott, Robert N.

doi:10.1007/bf00296829

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Collagen fibers were evidenced in the mucosa having a cross-ply arrangement, with adventitial fibers being axially aligned in the three regions, as has been demonstrated by another group. 26 Such a cross-ply structure of collagen in the lamina propria with a smaller fiber orientation angle with respect to the axial direction allows for greater extensibility circumferentially, since a larger strain is required to rotate the fibers toward the circumferential direction (Figures 3(c) and (e), 4(g)-(i), and 6(e) and (f)), and explains the directional differences in the stress-stretch curves (Figure 2). Along with the nonpreferential collagen orientation in the muscle layer, it also corroborates our finding that the failure stress at both the first and second ruptures as well as the peak elastic modulus was practically the same in the two directions (Figures 3(b) and (d), 4(c)-(f), and 6(a), (c), and (d)), because the same set of fibers provided the wall tissue with tensile strength and stiffness in all directions.…”

Section: Discussionmentioning

confidence: 99%

In vitro study of age-related changes in human ureteral failure properties according to region, direction, and layer

Sokolis

2019

Proc Inst Mech Eng H

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Knowledge of the capacity of the ureteral wall to withstand urodynamic or external stresses is essential to understand ureteral injury and rupture that mostly occur following trauma, but may also be secondary to obstructive uropathy. It has clinical significance as well in the prevention of iatrogenic injury, for example, during ureteroscopy, but no information is available with regard to the age-related failure properties and regional differences have not been systematically described. Uniaxial tensile testing was performed on 166 ureteral rings and strips from 21 humans free of overt urologic disease; histological evaluation was performed. The degree of layer participation to the intact wall failure stress (=tissue strength), peak elastic modulus (=stiffness), and failure stretch (=extensibility) was assessed by examining layer-specific ruptures in the stress–stretch data. Failure stress at and peak elastic modulus before the first (muscle/adventitial) rupture correlated inversely less with age ( p < 0.05 in few regions/directions) than failure stress at the second (mucosal) rupture ( p < 0.05 in the middle and lower ureter), consistent with the decreased mucosal thickness in ≥50-year-old subjects. Failure stretch at both ruptures did not correlate with age ( p > 0.05 in most regions/directions), paralleling elastin content. Correlations with age were more significant in females than males. Failure stress at the second rupture point was higher ( p < 0.05) distally in <50-year-old but not in ≥50-year-old subjects, justified by the increased collagen distally in the former. Directional differences in failure stretches ( p < 0.05 at all ages/regions/genders) were justified by preferentially axial collagen reinforcement. The presented results may establish the foundation for computational models of iatrogenic/accidental ureteral trauma.

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Section: Discussionmentioning

confidence: 99%

In vitro study of age-related changes in human ureteral failure properties according to region, direction, and layer

Sokolis

2019

Proc Inst Mech Eng H

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“…1 Fibre structure of organs. a Human ureter and a strip for tension tests (Dorrell et al [34]). b Small intestine (Gabella [35]) [22] can be used.…”

Section: Some Modified Materials Lawsmentioning

confidence: 99%

Physical response of hyperelastic models for composite materials and soft tissues

Dương

Nguyen

Staat

2015

Asia Pac. J. Comput. Engin.

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Interstitial stroma and carcinogenesis: ultrastructural observations in the rat bladder treated with N-butyl-N-(4-hydroxybutyl)nitrosamine

Zhang

Takenaka

1996

Urol. Res.

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This study describes ultrastructural alterations of the interstitial stroma in the rat bladder epithelium during N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-induced bladder carcinogenesis using scanning (SEM) and transmission (TEM) electron microscopy with NaOH treatment. The results obtained with SEM demonstrated the occurrence and development of stroma protrusions which exhibited pipe-like structures in the rat bladder epithelium following administration of BBN. Number and size of blood vessel sections also gradually increased both in the stroma and within the layer of the proliferated epithelial cells as examined by light microscopy (LM) and TEM. In this study stroma alterations were not only observed in malignant lesions of rat bladder, but hyperplastic lesions were also accompanied by stroma alterations. It is suggested that: (1) the interstitial stroma of the rat bladder epithelium may exhibit pathological changes in structure and these changes may correlate with the progression of epithelial cell proliferation following administration of BBN and (2) one of the most important alterations in the stroma is the occurrence of neovascularization, which may induce structural modification of the stroma in the processes of bladder tumor growth and development.

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Collagen arrangements in ureter

Cited by 6 publications

References 23 publications

In vitro study of age-related changes in human ureteral failure properties according to region, direction, and layer

In vitro study of age-related changes in human ureteral failure properties according to region, direction, and layer

Physical response of hyperelastic models for composite materials and soft tissues

Interstitial stroma and carcinogenesis: ultrastructural observations in the rat bladder treated with N-butyl-N-(4-hydroxybutyl)nitrosamine

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