Collagen‐Based Biomaterials for Regenerative Medicine

Hélary, Christophe; Pandit, Abhay

doi:10.1002/9783527652273.ch3

Cited by 2 publications

(3 citation statements)

References 98 publications

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“…The decellularization process is intended to remove cellular materials from tissue to render the resultant ECM scaffold compatible with implantation in an immunocompetent host, ,− whereas the solubilization of the acellular ECM must retain the type I collagen triple helix structure. This task is accomplished using diluted acid assisted with pepsin, which is responsible for removing telopeptides, which decrease the immunogenicity of collagen. ,, The use of different tissues requires the use of decellularization and extraction methods that can impact differentially composition and properties of the resulting ECM gel. Table compares several types of ECM hydrogels in terms of the tissue of origin, the biochemical composition, the processing conditions, and the main results in TERM studies.…”

Section: Processing–property Relationship In Decellularized Ecm Hydro...mentioning

confidence: 99%

“…is responsible for removing telopeptides, which decrease the immunogenicity of collagen. 31,35,60 The use of different tissues requires the use of decellularization and extraction methods that can impact differentially composition and properties of the resulting ECM gel. Table 2 compares several types of ECM hydrogels in terms of the tissue of origin, the biochemical composition, the processing conditions, and the main results in TERM studies.…”

Section: Decellularized Ecm Hydrogelsmentioning

confidence: 99%

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Characteristics of Collagen-Rich Extracellular Matrix Hydrogels and Their Functionalization with Poly(ethylene glycol) Derivatives for Enhanced Biomedical Applications: A Review

Rangel-Argote

Claudio‐Rizo

Mata‐Mata

et al. 2018

ACS Appl. Bio Mater.

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The hydrogels of natural extracellular matrix (ECM) are excellent biomaterials with promising applications in the physiological manufacture of three-dimensional (3D) constructs that replicate native tissue-like architectures and function as cargo-delivery, 3D bioprinting, or injectable systems. ECM hydrogels retain the bioactivity to trigger key cellular processes in the tissue engineering and regenerative medicine (TERM) strategies. However, they lack suitable physicochemical properties, which restricts their applications in vivo. This demand that mechanical and degradation properties of the ECM hydrogels must be balanced against biological properties. By incorporating poly(ethylene glycol) (PEG) into mammalian type I collagen-rich ECM substrates, this task can be accomplished. This review is focused on the use of PEG derivatives, widely used in formulations of pharmaceutical products or in synthesis of biomedical polyurethanes, as a strategy to modulate both physical and biological properties of natural ECM hydrogels. The processing–property relationship in decellularized ECM hydrogels, as well as the main results when used in TERM, are discussed. A comparison of the characteristics of PEG-ECM hydrogels is provided in terms of the improvement of structure, mechanics, and degradation behavior. Finally, the benefits of producing PEG-ECM hydrogels according to in vitro and in vivo performance in different proofs-of-concept of emergent biomedical technologies are overviewed.

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Section: Processing–property Relationship In Decellularized Ecm Hydro...mentioning

confidence: 99%

Section: Decellularized Ecm Hydrogelsmentioning

confidence: 99%

Characteristics of Collagen-Rich Extracellular Matrix Hydrogels and Their Functionalization with Poly(ethylene glycol) Derivatives for Enhanced Biomedical Applications: A Review

Rangel-Argote

Claudio‐Rizo

Mata‐Mata

et al. 2018

ACS Appl. Bio Mater.

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“…Hence, the implantation of biomaterials to treat bone disease or trauma appears promising. Bone substitutes need to have some specifications such as a good reliance on loading and a porous network to favour cell infiltration [7]. Nowadays, the research is towards the association of biomolecules with implants with the aim of enhancing osteointegration, promoting bone tissue repair or preventing infection [6].…”

Section: Bone Substitutesmentioning

confidence: 99%

Recent Advances in Biomaterials for Tissue Engineering and Controlled Drug Delivery

Hélary¹,

Desimone

2015

CPB

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In this review, recent advances in biomaterials developed to favor tissue repair are presented. The focus is particularly on devices used to promote bone repair, skin wound healing and nerve regeneration. In each case, the specifications for an ideal substitute and the recent advances in the field of these biomaterials are presented. Alternatively, drug delivery systems associated with biomaterials have been developed over the recent decades to stimulate wound healing without any side effects. For this purpose, the overview presents recent advances in medicated dressings for controlled release of antibiotic to prevent infections, growth factors to promote tissue regeneration and gene delivery to modulate cell phenotype.

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Collagen‐Based Biomaterials for Regenerative Medicine

Cited by 2 publications

References 98 publications

Characteristics of Collagen-Rich Extracellular Matrix Hydrogels and Their Functionalization with Poly(ethylene glycol) Derivatives for Enhanced Biomedical Applications: A Review

Characteristics of Collagen-Rich Extracellular Matrix Hydrogels and Their Functionalization with Poly(ethylene glycol) Derivatives for Enhanced Biomedical Applications: A Review

Recent Advances in Biomaterials for Tissue Engineering and Controlled Drug Delivery

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