Collagen-binding byDrosophilaSPARC is essential for survival and for collagen IV distribution and assembly into basement membranes

Abstract

The assembly of basement membranes (BMs) into tissue-specific morphoregulatory structures requires non-core BM components. Work in Drosophila indicates a principal role of collagen-binding matricellular glycoprotein SPARC (Secreted Protein, Acidic, Rich in Cysteine)