Collagen-Derived Membrane: Corneal Implantation

Dunn, Max S.; Nishihara, Tomio; Stenzel, Kurt H.; Branwood, A. W.; Rubin, Albert L.

doi:10.1126/science.157.3794.1329

Cited by 31 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, they are often modified for practical uses by various methods, such as UV-light irradiation, multivalent metal ions, and synthetic aldehyde-based cross-linkers [6,7]. However, the treatment by UV only modifies the surface instead of the bulk of the collagen [8], and the toxic nature of aldehyde compounds reflected in the process of manufacturing and application prohibits their utilization in food and biomaterials [9][10][11]. Thus, some natural polymers with favorable biocompatibility have been exploited as protein cross-linkers, such as genipin, oxidized alginate and dialdehyde starch [7,12,13].…”

Section: Introductionmentioning

confidence: 99%

Modification of collagen with a natural cross-linker, procyanidin

Shi

et al. 2011

International Journal of Biological Macromolecules

312

198

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Modification of collagen with a natural cross-linker, procyanidin

Shi

et al. 2011

International Journal of Biological Macromolecules

312

198

View full text Add to dashboard Cite

“…It should be pointed out that the metabolism of milligram quantities of attractant may bear no relationship to the few molecules required to stimulate the olfactory receptors and produce the psychopharmacological effects. 3. Some Nepeta cataria plants produce cis-transnepetalactone and trans,cis-nepetalactone in the ratio of 99.9 to 0.1, whereas in others a ratio of 70 to 30 may be found.…”

mentioning

confidence: 99%

“…Modification of these regions by proteolytic enzymes and by ultraviolet light leads to alterations in collagen which render it suitable for heteroimplantation. Collagen films implanted in rabbit corneas (3) have been in place for more than 2 years with no untoward reaction. We now report on the replacement of vitreous with specially prepared collagen gels.…”

mentioning

confidence: 99%

Collagen Gels: Design for a Vitreous Replacement

Stenzel

Dunn

Rubin

et al. 1969

Science

Self Cite

View full text Add to dashboard Cite

Clear, stable gels have been prepared from purified tropocollagen from calf skin; the collagen was solubilized with a proteolytic enzyme (Proctase) and stabilized by ultraviolet irradiation under nitrogen. These gels are clear, possess altered immunologic reactivity, and have properties of an ideal vitreous replacement. Implantations in rabbit and monkey eyes appear to be well tolerated, remain clear, and gradually disappear in about 2 months.

show abstract

“…The implantation of a biological material such as collagen results in good tissue tolerance both in vivo (7)(8)(9)(10)(11)(12)(13)(14)(15) and in vitro (16)(17)(18)(19)(20)(21). Collagen has been used in many biomedical applications such as in the dialysis membrane of an artificial kidney (7,(22)(23)(24), an artificial corneal membrane (8,9), as vitreous body (10)(11)(12), in skin and blood vessels (13,14), and as a surgical hemostatic agent (15).…”

mentioning

confidence: 99%

“…Collagen has been used in many biomedical applications such as in the dialysis membrane of an artificial kidney (7,(22)(23)(24), an artificial corneal membrane (8,9), as vitreous body (10)(11)(12), in skin and blood vessels (13,14), and as a surgical hemostatic agent (15). In 1969, Chvapil et al .…”

mentioning

confidence: 99%

Use of collagen-hydroxyethylmethacrylate hydrogels for cell growth.

Civerchia-Perez¹,

Faris²,

Lapointe³

et al. 1980

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Collagen-hydroxyethylmethacrylate hydrogels were prepared by polymerizing monomeric hydroxyethylmethacrylate in the presence of various concentrations of soluble native collagen. The resulting transparent hydrogels were evaluated as substrata for growth of IMR-90 human embryonic lung fibroblasts. Without collagen no significant growth occurred, whereas a dose-response curve expressing maximal cell growth against collagen concentration could be constructed quite readily by the use of appropriate hydrogels. The method allows for quantification of the collagen contribution to cell growth and, in a more general sense, provides the foundation for a relatively easy procedure to probe mechanisms of cell adhesion and cell differentiation. Among the many synthetic polymers presently used as biomaterials are those known as hydrogels. The term "hydrogel" refers to a broad class of polymeric materials that are swollen extensively in water but that do not dissolve in water (1). They have been used in a wide variety of biomedical applications and may be synthesized from monomers or monomers mixed with polymers. Hydrogels are attractive as biomaterials; they are highly permeable to water, ions, and small molecules (1). Hydrogels such as poly(2-hydroxyethylmethacrylate) (HEMA) and other synthetic polymers are relatively nontoxic and well tolerated when implanted in vivo (2, 3) or when added to an actively metabolizing tissue-culture system (4-6).The implantation of a biological material such as collagen results in good tissue tolerance both in vivo (7-15) and in vitro (16)(17)(18)(19)(20)(21). Collagen has been used in many biomedical applications such as in the dialysis membrane of an artificial kidney (7,(22)(23)(24), an artificial corneal membrane (8, 9), as vitreous body (10-12), in skin and blood vessels (13,14), and as a surgical hemostatic agent (15). In 1969, Chvapil et al. .(25) described good tissue tolerance in vivo of a collagen-hydrophilic polymer that they had constructed from a calf-hide collagen sponge immersed in HEMA monomer, allowing polymerization to occur on the sponge surface. They attributed the biocompatibility of this material to the porosity of the sponge, which permitted the ingrowth of blood vessels. In 1977, Shimizu et al. (26) reported high tissue compatibility of laminar copolymers of bovine collagen and various synthetic polymers that they had constructed by applying plasma discharge and y-irradiation to effect crosslinkage between a layer of collagen coated onto a layer of synthetic polymer. More recent studies involving collagen-cell surface interactions have focused on the role of fibronectin (27,28).In a study by Folkman and Moscona (29), poly(HEMA) coating was used as a means of preventing fibroblast growth on standard tissue-culture flasks (Falconware). Similarly, a morphologic study of mouse fibroblasts grown on syntheticcoated coverslips found poly(methylmethacrylate) and other polymers to be unfavorable surfaces for cell adhesion and growth (30). In the present communication, w...

show abstract

Collagen-Derived Membrane: Corneal Implantation

Cited by 31 publications

References 8 publications

Modification of collagen with a natural cross-linker, procyanidin

Modification of collagen with a natural cross-linker, procyanidin

Collagen Gels: Design for a Vitreous Replacement

Use of collagen-hydroxyethylmethacrylate hydrogels for cell growth.

Contact Info

Product

Resources

About