Collagen Expression in the Pregnant Human Cervix Is Decreased With Labor

Heller, Debra S.; Goldsmith, Laura T.; Aboujaoude, Ramzi; Kaplan, Cynthia; Baergen, Rebecca N.; Cole, Donna J.

doi:10.1097/lgt.0b013e31822bb004

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…Constitutional changes in the physiology of the cervix during pregnancy may also affect the flexibility of the cervix and significantly modify UCA. At 2012 Heller et al evaluated uterine cervices from 22 cases of obstetric hysterectomy and observed that the mean percent of collagen was significantly higher in cervices on nonpregnant uteri compared to pregnant uteri (73.5±3.5% versus 21.5±2.2%) [23]. This study indicates the presence of significant differences in the physiology of the cervix during pregnancy.…”

Section: Discussionmentioning

confidence: 90%

Assessment of Uterocervical Angle Width as a Predictive Factor of Preterm Birth: A Systematic Review of the Literature

Daskalakis

Theodora

Antsaklis

et al. 2018

BioMed Research International

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Background Uterocervical angle (UCA) has been recently proposed as a potential marker that could accurately predict preterm birth (PTB). The purpose of the present systematic review is to accumulate current evidence and provide directions for future research. Materials and Methods We used the Medline (1966–2018), Scopus (2004–2018), Clinicaltrials.gov (2008–2018), EMBASE (1980-2018), Cochrane Central Register of Controlled Trials CENTRAL (1999-2018), and Google Scholar (2004-2018) databases in our search. Results Eleven studies were finally included in the present systematic review that evaluated data from 3,018 women. The significant heterogeneity in terms of outcome reporting and outcome reporting measures (use of optimal cut-off values) precluded meta-analysis. However, existing data support that second trimester UCA measurement might be used as a predictive factor of PTB <34 weeks, as at least two studies in unselected singleton pregnancies and two studies in pregnancies with an ultrasonographically shortened cervix seem to support this hypothesis. The most commonly reported cut-off values were 105° and 95°. Conclusions UCA measurement during the second trimester of pregnancy may be a useful method of determining women at risk of delivering preterm. However, more studies are needed to assess the reproducibility of these findings and reach conclusive evidence.

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Section: Discussionmentioning

confidence: 90%

Assessment of Uterocervical Angle Width as a Predictive Factor of Preterm Birth: A Systematic Review of the Literature

Daskalakis

Theodora

Antsaklis

et al. 2018

BioMed Research International

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“…The distal cervical portion has a greater ratio than the proximal portion [ 8 ]. And it is still uncertain if the cervical collagen contents and cellular contents may be changed or remodeled with age, parity, different menstrual cycle, pregnancy or delivery [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the stiffness of normal cervix and its change with different factors using transvaginal two-dimensional shear wave elastography under strict quality control

Zhang

et al. 2023

BMC Med Imaging

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Background The usefulness of transvaginal two-dimensional shear wave elastography (2D SWE) for cervical lesions is still uncertain. This study was to explore the value of transvaginal 2D SWE in the evaluation of the stiffness of normal cervix and its change with different factors under strict quality control (QC). Methods Two hundred patients with normal cervix were included in this study and were examined using quantitative 2D SWE to evaluate cervical stiffness and its change with different factors under strict QC. Results Intra-observer concordance of transvaginal 2D SWE parameters in midsagittal planes were acceptable with intraclass correlation coefficients higher than 0.5. Transvaginal 2D SWE parameters were significantly higher than the corresponding transabdominal parameters. 2D SWE parameters of internal cervical os were significantly higher than the corresponding parameters of external cervical os in a transvaginal midsagittal plane. 2D SWE parameters of external cervical os increased significantly over 50 years old, while these parameters of internal cervical os didn’t change significantly with increasing age. 2D SWE parameters of internal cervical os of horizontal position cervix were significantly higher than those of vertical position cervix. SWE parameters of normal cervix did not change according to different menstrual cycles, parities and human papilloma virus test results. Conclusions Transvaginal 2D SWE under strict QC could provide quantitative, repeatable and reliable cervical stiffness information. Internal cervical os was stiffer than external cervical os. Menstrual cycles, parities and human papilloma virus test results wouldn’t affect cervical stiffness. However, age and cervical positions should be taken into condition while interpreting 2D SWE results of cervical stiffness.

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“…Uterine preparation for labor involves a switch from a quiescent profile to a contractile profile (8,9), and it is widely accepted that these changes are associated with the modulation of the expression profile of myometrial smooth muscle cells (SMCs), with the down-regulation of proliferation-activating proteins and collagen expression (10), and the overexpression of inflammatory cytokines (IL-1b,I L -6 ,a n dT N Fa) (3,6), apoptosis proteins (caspase-3, Bax) (11,12), extracellular matrix remodeling proteins [matrix metalloproteinase (MMP) 2 and MMP9] Abbreviations: CA, chorioamnionitis; CD, cluster of differentiation; Cox-2, cyclooxygenase-2; DAF, 4-amino-5-methylamino-29,79-difluorofluorescein; DHE, dihydroethidium; GSH, reduced glutathione; HIF, hypoxia inducible factor; MC, myometrial cell; MMP, matrix metalloproteinase; NAC, N-acetylcysteine; NADPHox, NADPH oxidase; NP, normal pregnancy; OCT, optimal cutting temperature; ROS, reactive oxygen species; SMC, smooth muscle cell; SOD, superoxide dismutase (13) and leukocyte recruitment mediators (monocyte chemotactic protein, VEGF) (5,14).…”

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confidence: 99%

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Glutathione prevents preterm parturition and fetal death by targeting macrophage‐induced reactive oxygen species production in the myometrium

et al. 2015

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Preterm birth is an inflammatory process resulting from the massive infiltration of innate immune cells and the production of proinflammatory cytokines in the myometrium. However, proinflammatory cytokines, which induce labor in vivo, fail to induce labor-associated features in human myometrial cells (MCs). We thus aimed to investigate if reactive oxygen species (ROS) production could be the missing step between immune cell activation and MC response. Indeed, we found that ROS production is increased in the human preterm laboring myometrium (27% ROS producing cells, respectively, versus 2% in nonlaboring controls), with 90% ROS production in macrophages. Using LPS-stimulated myometrial samples and cell coculture experiments, we demonstrated that ROS production is required for labor onset. Furthermore, we showed that ROS are required first in the NADPH oxidase (NADPHox)-2/NF-kB-dependent macrophage response to inflammatory stimuli but, more importantly, to trigger macrophage-induced MCs transactivation. Remarkably, in a murine model of LPS-induced preterm labor (inducing delivery within 17 hours, with no pup survival), cotreatment with glutathione delayed labor onset up to 94 hours and prevented in utero fetal distress, allowing 46% pups to survive. These results suggest that targeting ROS production with the macrophage-permeable antioxidant glutathione could constitute a promising strategy to prevent preterm birth.-Hadi, T., Bardou, M., Mace, G., Sicard, P., Wendremaire, M., Barrichon, M., Richaud, S., Demidov, O., Sagot, P., Garrido, C., Lirussi, F. Glutathione prevents preterm parturition and fetal death by targeting macrophage-induced reactive oxygen species production in the myometrium. FASEB J. 29, 2653-2666 (2015). www.fasebj.org

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Collagen Expression in the Pregnant Human Cervix Is Decreased With Labor

Abstract: Collagen expression seems to be reduced in the postpartum cervix, particularly after labor has ensued.

Cited by 3 publications

References 13 publications

Assessment of Uterocervical Angle Width as a Predictive Factor of Preterm Birth: A Systematic Review of the Literature

Assessment of Uterocervical Angle Width as a Predictive Factor of Preterm Birth: A Systematic Review of the Literature

Evaluation of the stiffness of normal cervix and its change with different factors using transvaginal two-dimensional shear wave elastography under strict quality control

Glutathione prevents preterm parturition and fetal death by targeting macrophage‐induced reactive oxygen species production in the myometrium

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