Collagen for bone tissue regeneration

Ferreira, Ana Marina; Gentile, Piergiorgio; Chiono, Valeria; Ciardelli, Gianluca

doi:10.1016/j.actbio.2012.06.014

Cited by 775 publications

(590 citation statements)

References 119 publications

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“…The porous structure and tissue-like soft and wet properties of hydrogels have potential applications in the development of implantable drug reservoirs and cell scaffolds. [4][5][6][7] Moreover, hydrogels that are based on biomolecules, 8 such as proteins (e.g., collagen [Col] 9 and gelatin 10,11 ) and polysaccharides (e.g., hyaluronic acid 12,13 and chitosan 14,15 ), acquire not only excellent biocompatibility but also specific bioactivity from their building blocks. These features can artificially mimic the extracellular matrix (ECM) for cell growth and proliferation, 16 and are highly advantageous in tissue regenerative therapy.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of tough poly(ethylene glycol)/collagen double network hydrogels for tissue engineering

Chen

Yuan

et al. 2017

J Biomedical Materials Res

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In this study, a series of poly(ethylene glycol)/collagen (PEG/Col) double network (DN) hydrogel is fabricated from PEG and Col. Results of the compressive strength test indicate that the strength and toughness of these DN hydrogels are significantly enhanced. The fracture strength of PEG/ Col DN hydrogels increases by 9-to 12-fold compared with that of PEG single network (SN) hydrogel, and by 36-to 48-fold compared with that of Col SN hydrogel. Taking advantage of both PEG and Col building blocks, the PEG/Col DN hydrogels possess a strengthened skeleton. Moreover, the water-storage capability and favorable biocompatibility of Col are effectively maintained. Given that the DN hydrogels can provide the appropriate environment for the adhesion, growth, and proliferation of MC3T3-E1 cells, PEG/Col DN hydrogels have potential as a load-bearing tissue repair material.

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Section: Introductionmentioning

confidence: 99%

Fabrication of tough poly(ethylene glycol)/collagen double network hydrogels for tissue engineering

Chen

Yuan

et al. 2017

J Biomedical Materials Res

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“…Both are biodegradable and their degradation results in non-toxic by-products (Huang et al, 2005;Lee et al, 2001;Nicodemus and Bryant, 2008). Current medical uses include applications in plastic and reconstructive surgery and as a vehicle for drug delivery (Ferreira et al, 2012). Collagen type I as a hydrogel is also investigated for bone and soft tissue regeneration (Badylak et al, 2009;Bron et al, 2012;Cen et al, 2008;Ferreira et al, 2012).…”

Section: Collagen and Gelatinmentioning

confidence: 99%

“…Collagen is one of the most abundant proteins found in the human body, making up about one third of our total protein weight (Ferreira et al, 2012). Gelatin is a material derived from animal collagen usually through thermal denaturation.…”

Section: Collagen and Gelatinmentioning

confidence: 99%

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Schutgens¹,

Tryfonidou²,

Smit³

et al. 2015

eCM

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Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the number one cause of loss of quality-adjusted life years. In search of alternatives to the current less than optimal and usually highly invasive treatments, regenerative strategies are being devised, none of which has reached clinical practice as yet. Strategies include the use of stem cells, gene therapy, growth factors and biomaterial carriers. Biomaterial carriers are an important component in musculoskeletal regenerative medicine techniques. Several biomaterials, both from natural and synthetic origin, have been used for regeneration of the IVD in vitro and in vivo. Aspects such as ease of use, mechanical properties, regenerative capacity, and their applicability as carriers for regenerative and anti-degenerative factors determine their suitability for IVD regeneration. The current review provides an overview of the biomaterials used with respect to these properties, including their drawbacks. In addition, as biomaterial application until now appears to have been based on a mix of mere availability and intuition, a more rational design is proposed for future use of biomaterials for IVD regeneration. Ideally, high-throughput screening is used to identify optimally effective materials, or alternatively medium content comparative studies should be carried out to determine an appropriate reference material for future studies on novel materials.

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“…Scaffolds also play an important role in repairing bone defect by fabricating three-dimensional (3D) engineered bone tissues in vitro (McNamara et al 2014;Yasui et al 2014). The materials used for constructing the engineered bone or cartilage include chitosan (Pok et al 2014), collagen (Ferreira et al 2012), PLGA (Doğan et al 2014), etc. However, these materials exhibit intrinsic defects in one or more features such as poor degradation rate, hydrophilicity, biocompatibility and undesirable mechanical property which inhibit their utilization in bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Repair of bone defects using dynamic fabricated tissue-engineered bone based on a bio-derived porous bone scaffold

Song

et al. 2016

Animal Cells and Systems

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Fabrication and transplantation of tissue-engineered bones in a rotating wall vessel bioreactor (RWVB) was studied in the present study aiming to repair segmental bone defects. Osteoblasts were transfected with green fluorescent protein prior to seeding on bio-derived porous bone scaffolds at a density of 1 × 10 6 cells/mL and cultured in an RWVB for one week. For comparison, constructs were also cultured in a static condition. Morphology and structure of fabricated bones were examined using an inverted microscope, scanning electron microscope and histology analysis via hematoxylin-eosin and toluidine blue staining. Moreover, an animal model for repairing segmental bone defects of a Zelanian rabbit was used to assess the efficacy and biosafety of fabricated bones. In conclusion, tissue-engineered bones grew favorably in RWVB. In animal study, a preliminary repair of bone defects was noticed only in the experimental group after 4 weeks of implantation. Using RWVB, the fabricated tissue-engineered bone constructs were approved with better bio-capability in repairing the segmental bone defect. ARTICLE HISTORY

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Collagen for bone tissue regeneration

Cited by 775 publications

References 119 publications

Fabrication of tough poly(ethylene glycol)/collagen double network hydrogels for tissue engineering

Fabrication of tough poly(ethylene glycol)/collagen double network hydrogels for tissue engineering

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Repair of bone defects using dynamic fabricated tissue-engineered bone based on a bio-derived porous bone scaffold

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