Collagen I membranes for tendon repair: Effect of collagen fiber orientation on cell behavior

Gigante, Antonio; Cesari, E.; Busilacchi, Alberto; Manzotti, S; Kyriakidou, Kyriaki; Greco, Francesco; Primio, Roberto Di; Mattioli‐Belmonte, Monica

doi:10.1002/jor.20812

Cited by 62 publications

(61 citation statements)

References 25 publications

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“…These observations support the concept of a beneficial effect of these drug combination on the prevention of osteopenia in ovariectomised animals . Interestingly recent experimental studies have shown that the association of Vitamin K and D stimulates in vitro osteoblast differentiation in fracture site derived human mesenchymal stem cells (Gigante et al, 2008). These findings are suggestive of an additional target for reparative treatments.…”

Section: Combined Treatment With Vitamin K2 and Vitamin D3 In Ovariecmentioning

confidence: 90%

The Role of Vitamin K in Bone Remodeling and Osteoporosis

Giammanco¹,

Majo²,

Leto³

et al. 2012

JFR

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Vitamin K is an essential fat soluble vitamin involved in the regulation of normal coagulation. However, growing evidence highlights that this molecule appears to be also implicated in the regulation of other important biological functions such as bone mineralization, calcium homeostasis, apoptosis, cell growth and signal transduction. In particular, many studies have focused their attention on the protective effects of vitamin K on bone tissue in the outlook of its use in the prevention and treatment of osteoporosis in post-menopausal women. The objective of the present paper is to review data of the literature regarding the metabolic effects of Vitamin K in bone tissue and its clinical role in the prevention and treatment of osteoporosis.

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Section: Combined Treatment With Vitamin K2 and Vitamin D3 In Ovariecmentioning

confidence: 90%

The Role of Vitamin K in Bone Remodeling and Osteoporosis

Giammanco¹,

Majo²,

Leto³

et al. 2012

JFR

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“…sterilization, cell rinsing, freeze drying, etc. ); therefore these types of grafts are not viable in nature because their cellular structures are commonly destroyed during sterilization and other important tissue processing [72][73][74][75][76][77][78][79][80][81][82][83][84][85]. Therefore, it is a fact that the allo-and xenografts have significantly lower incorporative properties with the healing tissue and this is another major limitation which results in rapid absorption of the graft during tendon or ligament healing [69,72].…”

Section: Graft Options In Managing Large and Massive Tendon And Ligammentioning

confidence: 99%

“…This method of tissue engineering has been used for many years to decrease the antigenicity of the viable grafts [68][69][70][71][72]. Newer approaches have been developed by many and newer tissue engineered products are introduced in the recent years [73][74][75][76][77][78][79][80][81][82][83][84][85]. Basically, tissue engineering could be divided into four major categories including tissue scaffolds, healing promotive factors, stem cells and gene therapy [12].…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…In that case, the new tissue regenerates through the free spaces of the inner parts of the non-absorbable scaffold but the newly regenerated tissue cannot replace the graft [25]. If the scaffold was not immunogenic but was also biodegradable, an acceptable outcome would be expected and achieved [76,77,85]. Studies suggest that these types of scaffolds would not be completely rejected by the host and some portion of the scaffold may be preserved [28].…”

Section: Host-graft Interactionmentioning

confidence: 99%

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Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Moshiri¹,

Oryan²

2013

J Sports Med Doping Stud 2013

102

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Tendons transmit forces from muscle to bone and provide the joint function and ligaments transmit forces from bone to bone and provide joint stability. Tendon and ligament injuries have high incidence and management of tendon and ligament injuries is technically demanding because the healing response of these soft connective tissues is low. In addition, number of the available options to be considered as tissue replacement for large defects is low and healing of tendon and ligaments is faced to significant limitations. Among the available options, autografts are still gold standard but all the auto-allo and xenografts have their own limitations. Tissue engineering is a newer option but it is still primitive to be applicable extensively, in clinical setting. Tissue engineering could be divided into four categories including scaffolds, healing promotive factors, stem cells and gene therapy. To be able to have a good judgment regarding the management of tendon and ligament injuries, it is crucial to have a basic knowledge of tendon and ligament healing and regeneration. In this review, we discussed various types of tendon and ligament injuries and their incidence, and introduced the available and future options in managing large and massive tendon and ligament injuries. We specifically discussed the tissue engineering and it's advantageous and disadvantageous. To give a better clarification for the readers, we described different phases and cascades of tendon and ligament healing, modeling and remodeling, host-graft interaction after implantation of the graft and various types of prosthetic implants and finally provided some suggestions for the future investigations.

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“…Tendons are slowly healed after injury with a poor spontaneous regeneration ability (Gigante et al, 2009;Song et al, 2010). Oryan et al (2010) classified tendon injuries into acute and chronic, and they demonstrated that it also could be categorized by etiology; the most significant tendon injuries involved sharp tendon ruptures, tendinopathic forms of tendon ruptures and congenital or acquired defects which are characterized by impaired healing response.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Histopathological Study of Repaired Tendons Wrapped with Two Biological Matrices in Bucks

AL-Falahi¹,

Salih²

2016

Adv. Anim. Vet. Sci.

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| This study was planned to evaluate the efficacy of two biological matrices represented by autologous platelet rich fibrin matrix (PRFM), as well as a cross linked decellularized caprine pericardial extracellular matrix (PECM) on enhancing healing of the experimentally severed superficial digital flexor tendon in a goat model. It was carried out on 48 adult bucks, which were divided randomly into three equal groups. Under sedation and regional anesthesia, SDFT was severed at the mid metacarpal region of the right forelimb. In the first control group, tenorrhaphy was performed and left without additives. While in the second group the tenorrhaphy site was wrapped with autologous platelet rich fibrin strips which were prepared at the time of operation, as well as in the third group the tenorrhaphy site was wrapped with a cross linked decellularized PECM strip which was previously prepared from the whole fresh caprine pericardium. The histopathological evaluation in this study revealed that the neovascularization, cellularity and collagen fiber alignment scores were significantly increased in both treated groups as compared to the control group. In conclusion, both biological matrices led to improvement in tendon healing and repair, without any complications, but the PECM gave superior results in tendon repair when compared to other groups.

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Collagen I membranes for tendon repair: Effect of collagen fiber orientation on cell behavior

Cited by 62 publications

References 25 publications

The Role of Vitamin K in Bone Remodeling and Osteoporosis

The Role of Vitamin K in Bone Remodeling and Osteoporosis

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

A Comparative Histopathological Study of Repaired Tendons Wrapped with Two Biological Matrices in Bucks

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