Collagen/Nigella sativa/chitosan inscribed electrospun hybrid bio-nanocomposites for skin tissue engineering

Innovative approaches in skin therapy: bionanocomposites for skin tissue repair and regeneration

“…16 Their unique characteristics, such as mechanical strength, biodegradability, moisture retention, cellular interactions, antimicrobial properties, gel-forming capabilities, and fibrous structure, contribute to their versatility and potential in the field of tissue engineering and regenerative medicine. 17,18 For instance, silk fibroin is renowned for its remarkable mechanical strength, biocompatibility, and biodegradability. 19 Incorporating silk fibroin into BNCs not only imparts structural integrity and support to the regenerated tissue but also ensures gradual degradation of the BNC scaffold, allowing the regenerated tissue to assume its functionality.…”

Developing and Screening of a Bacteria-Fighting and Moisture-Controlling Coccinia grandis and Poly(vinyl alcohol) Electrospun Nanofibrous Mat

“…This technology is very adaptable, low-cost, capable of creating continuous nanofibers, simple to functionalize the surface, industrially relevant, and unique in that it can manufacture fibers ranging in size from several micrometers to nanometers when electrical forces are applied. , A flexible method for producing nanofibers with sizes varying from a few nanometers to several micrometers is electrospinning. A polymer solution is subjected to a high voltage, which creates a jet that is drawn in the direction of a collector . The researchers added a natural antibacterial peptide and an anti-inflammatory drug to the nanofibers .…”

“…Owing to a number of advantageous characteristics such as the soluble nature in water, biological adaptability, drug delivery, reliability, mechanical attributes, and customizable features, PVA is a polymer matrix that is frequently utilized in electrospinning for biomedical purposes . For single or bilayer approaches, PVA solution with a concentration of 5–10% (w/v) produces good fiber formation . Furthermore, “green polymer” PVA possesses superior film-forming capabilities and is nontoxic .…”

“…A polymer solution is subjected to a high voltage, which creates a jet that is drawn in the direction of a collector. 9 The researchers added a natural antibacterial peptide and an anti-inflammatory drug to the nanofibers. 10 In vitro and in vivo, the nanofibrous membrane efficiently prevented bacterial growth and decreased the level of inflammation.…”

“…Kaempferol-3-O-β-D-glucoside has a free hydroxyl group and electronegative oxygen present in it 36. The FTIR curve depicted a significant number of individual molecules, and a band broadening after 3000 cm −1 points to the development of hydrogen bond 9. It is thought that the development of weak van der Waals bonds and representing H-bonds has collaborative potentials within the hydroxyl group of the PVA polymer and C. grandis leaf extract, as shown in Figure9.…”