“…An impressive increment in the volume (or concentration) of myocardium occupied by collagen (see Figure 2) has been seen in adults with aortic valvular stenosis (Anderson et al, 1979;Caspari et al, 1977;Hess et al, 1981;Oldershaw et al, 1980;Schaper & Schaper, 1983;Schwarz et al, 1978;St John Sutton et al, 1980), children with congenital aortic stenosis or coarctation of the aorta (Cheitlin et al, 1980), and adults with systemic hypertension (Pearlman et al, 1982;Tanaka et al, 1986). In each circumstance, the accumulation of collagen, or myocardial fibrosis, was not associated with epicardial coronary artery disease.…”