Collagen materials with oriented structure for biomedical applications

Zeng, Rui; Tang, Keyong; Tian, Huafeng; Pei, Ying

doi:10.1002/pol.20230664

Cited by 8 publications

(3 citation statements)

References 206 publications

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“…There is a precedent for the use of recombinant proteins in textile applications. Spider silk, 186,187 elastin, 188 resilin, 189,190 collagen, 191 fibroin, 192 and keratin 193 are all well-characterized structural proteins, and have been utilized in textiles in recent years, most commonly via electrospinning of individual fibres, or casting and self-assembly in foams and hydrogels. However, precisely controlled porosity is difficult in such systems.…”

Section: Functionalization and Applicationsmentioning

confidence: 99%

Porous protein crystals: synthesis and applications

Jones,

Snow

2024

Chem. Commun.

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Section: Functionalization and Applicationsmentioning

confidence: 99%

Porous protein crystals: synthesis and applications

Jones,

Snow

2024

Chem. Commun.

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“…These microfibrils aggregate into larger collagen fibrils, which further bundle to form collagen fibers. The arrangement of these fibers plays a crucial role in bone’s mechanical strength . Specifically, fibers aligned parallel to the direction of the load exhibit greater resistance to tension, while those perpendicular are more resistant to compression .…”

Section: Introductionmentioning

confidence: 99%

“…The arrangement of these fibers plays a crucial role in bone’s mechanical strength. 9 Specifically, fibers aligned parallel to the direction of the load exhibit greater resistance to tension, while those perpendicular are more resistant to compression. 10 The density and organization of the collagen network are critical for the adequate mineralization of bone.…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies for regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present a promising biomimetic platform for bone regeneration by mimicking the native extracellular matrix architecture. Through optimized fabrication techniques and the incorporation of active biomolecular components, NFMS can precisely replicate the nanostructure and biochemical cues essential for osteogenesis promotion. Furthermore, NFMS exhibit versatile properties, including tunable morphology, mechanical strength, and controlled release kinetics, augmenting their suitability for tailored bone tissue engineering applications. NFMS enhance cell recruitment, attachment, and proliferation, while promoting osteogenic differentiation and mineralization, thereby accelerating bone healing. This review highlights the pivotal role of NFMS in bone tissue engineering, elucidating their design principles and key attributes. By examining recent preclinical applications, we assess their current clinical status and discuss critical considerations for potential clinical translation. This review offers crucial insights for researchers at the intersection of biomaterials and tissue engineering, highlighting developments in this expanding field.

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The microstructural evolution of material extrusion based additive manufacturing of polyetheretherketone under different printing conditions and application in a spinal implant

Irez,

Dogru

2024

Polymer Engineering & Sci

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With the advances in additive manufacturing, polyetheretherketone (PEEK), a biocompatible polymer, can be used in biomedical applications such as spinal implants. This paper aims to investigate the evolution of the microstructure of PEEK parts manufactured by material extrusion (MEX)‐based additive manufacturing with different printing parameters. The effect of layer thickness (LT) and nozzle diameter on mechanical properties was investigated using tensile, Charpy impact, and short beam strength (SBS) tests. Two different LTs, 0.1 and 0.2 mm, and two different nozzle diameters, 0.6 and 0.8 mm, were used as printing parameters. By increasing the LT, tensile strength dropped by around 24%, and impact strength by almost 55%. Moreover, altering the LT resulted in a 15% decrease in interlaminar shear strength (ILSS) from the SBS test. In addition, increasing the nozzle diameter also led to a significant reduction in all of the results as tensile strength, Charpy impact strength, and ILSS. The results were also consolidated by scanning electron microscopy. The main findings were that increasing LT leads to an increase in microstructural defects that act as stress concentrators. Following the tests, response surface methodology (RSM) was used to determine optimal printing parameters. In the end, using the optimum printing parameters from the RSM study, a structural analysis of a MEX‐printed spinal implant was conducted through finite element method, considering the loading cases mimicking daily human body motions.Highlights As layer thickness increased, tensile and impact strength dropped. Tensile and impact strength dropped truly with increasing nozzle diameter. SEM revealed that increasing layer thickness causes more microstructural flaws. FEM analysis showed that PEEK‐based implant provides structural integrity.

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Collagen materials with oriented structure for biomedical applications

Cited by 8 publications

References 206 publications

Porous protein crystals: synthesis and applications

Porous protein crystals: synthesis and applications

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

The microstructural evolution of material extrusion based additive manufacturing of polyetheretherketone under different printing conditions and application in a spinal implant

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