Collagen membranes for skin wound repair: A systematic review

Abstract

Membranes or skin dressing are common treatments for skin wound injuries, collagen being one the most effective materials for their manufacturing. Many different sources of collagen with diverse methods of extraction and processing have been used, with evidence of positive effects on the stimulation of skin wound healing. In spite of these factors, there is still limited understanding of the interaction between collagen membranes and biological tissues, especially due to the series of different types of collagen origin. In this context, this study aimed to conduct a systematic review of the available literature examining the effect of various collagen membranes for accelerating skin wound healing in experimental animal models and clinical trials. The present review was performed from March to May of 2020 searching in two databases (PubMed and Scopus). The following Medical Subject Headings (MeSH) descriptors were used: “collagen”, “dressing”, “membranes”, “skin” and “wound”. After the eligibility assessment, 16 studies were included and analyzed. The studies demonstrated that collagen was obtained predominantly from bovine and porcine sources, by acetic acid and/or enzyme dissolution. Additionally, most of the studies demonstrated that the membranes were processed mainly by freeze-drying or lyophilization methods. All the in vivo and clinical trial studies evidenced positive outcomes in the wound healing process, thus confirming that collagen membranes are one of the most efficient treatment for skin wounds, highlighting the enormous potential of this biomaterial to be used for skin tissue engineering purposes.

Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study

“…The areas related to general physical fitness (crouching, kneeling down, walking at a brisk pace, playing a sport, exerting oneself physically) did not change significantly in any of the groups, which may be related to the age of the respondents, on average, 64 years. Studies evaluating other collagen products in the treatment of VLUs have also confirmed their benefits and showed improved quality of life [ 44 , 55 , 66 , 67 , 68 ]. Nevertheless, we are the first to apply collagen to the surrounding skin, showing an improvement in skin parameters.…”

“…Alternatively, collagen can be produced by heterologous expression in mammalian, insect, and yeast cells. It can also be produced by Escherichia coli [ 44 ]. Due to its low antigenicity and inherent biocompatibility with most endogenous tissue, natural collagen may be used for many pre- and post-operative surgical procedures (e.g., as adhesives), and also as a wound dressing.…”

A Combined Cyanine/Carbomer Gel Enhanced Photodynamic Antimicrobial Activity and Wound Healing

“…While the wound closure rates in Cy-CBMG/laser group and Cy/laser group were nearly 100% and 87.4% in day 12, respectively, poor wound healing rates were observed in other groups (<75%). Collagen formation is a hallmark of wound regeneration and skin reconstruction [43]. As shown in Figure 6c, Masson's trichrome staining indicated that the regenerated skin tissues in Cy-CBMG/laser group displayed a shorter wound gap (Figure 6d) and denser collagen fiber deposition (Figure 6e), as compared with other groups.…”

The clinical efficacy of collagen dressing on chronic wounds: A meta-analysis of 11 randomized controlled trials

“…A previous study Adverse events: (A) the pooled result; (B) sensitivity analysis. (6) demonstrated that collagen has a positive effect on wound healing by reviewing 16 studies (14 studies for animals and only 2 studies for humans). However, a metaanalysis was not performed due to high heterogeneity and patients with diabetes mellitus were excluded whereas we performed a meta-analysis and included diabetes mellitus patients.…”

“…As a potential treatment, collagen dressings are applied in many fields such as chronic wounds, and reconstructive, separately or together with other materials ( 5 ). Meanwhile, Tiago et al also demonstrated that collagen was the most efficient treatment for skin wounds ( 6 ). Therefore, collagen is in a dominant position in wound healing.…”