Collagen metabolism markers as a reflection of bone and soft tissue turnover during the menstrual cycle and oral contraceptive use

Wreje, Ullacarin; Brynhildsen, Jan; Åberg, H; Byström, Birgitta; Hammar, Mats; Schoultz, Bo von

doi:10.1016/s0010-7824(00)00106-2

Cited by 28 publications

(24 citation statements)

References 37 publications

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“…No significant difference in the s‐testosterone was observed between groups in the present study. S‐SHBG was markedly enhanced in OC‐users, as observed by others (Wreje et al, 2000). Because SHBG has a high affinity for testosterone, the estimated bioavailable testosterone was markedly lower in OC‐users compared with the controls.…”

Section: Discussionsupporting

confidence: 81%

Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

Hansen

Langberg

Holm

et al. 2011

Scandinavian Med Sci Sports

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Oral contraceptive (OC) treatment has an inhibiting effect on protein synthesis in tendon and muscle connective tissue. We aimed to investigate whether OC influence myofibrillar protein turnover in young women. OC-users (24±2 years; Lindynette® n=7, Cilest® n=4) and non-OC-users (controls, 24±4 years n=12) performed one-legged kicking exercise. The next day, the myofibrillar protein fractional synthesis rate (FSR) was measured using stable isotopic tracers ((13)C-proline) while the subjects were fed standardized nutrient drinks. Simultaneously, a marker for myofibrillar protein breakdown, 3-methyl-histidine (3-MH), was measured in the interstitial fluid of the vastus lateralis. Measurements were performed in both legs. In general, myofibrillar protein FSR was lower in OC-users (two-way analysis of variance, P<0.05), although the difference seemed to depend on the OC type. Interstitial 3-MH in the skeletal muscle was not different between groups and did not vary by OC type. Exercise did not change myofibrillar protein FSR or 3-MH concentrations. Serum androstenedione and bioavailability of testosterone were lower in OC-users. In conclusion, the results indicate that the use of OC has an inhibiting effect on myofibrillar protein synthesis and the magnitude of the effect may depend on the type of OC. In contrast, there was no effect of OC on myofibrillar protein breakdown in the fed state.

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Section: Discussionsupporting

confidence: 81%

Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

Hansen

Langberg

Holm

et al. 2011

Scandinavian Med Sci Sports

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“…A reduction in free-IGF-I in the blood has been shown by others (17,60,66). However, the difference in free IGF-I concentrations within the tissues is novel.…”

Section: Effects On Igf-i and Igfbpsmentioning

confidence: 84%

Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women

Hansen

Miller²,

Holm³

et al. 2009

Journal of Applied Physiology

106

104

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M, Langberg H. Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women. J Appl Physiol 106: 1435-1443, 2009. First published October 9, 2008 doi:10.1152/japplphysiol.90933.2008Women are at greater risk than men for certain kinds of diseases and injuries, which may at least partly be caused by sex hormonal differences. We aimed to test the influence of estradiol in vivo on collagen synthesis in tendon, bone, and muscle. Two groups of young, healthy women similar in age, body composition, and exercisetraining status were included. The two groups were either habitual users of oral contraceptives exposed to a high concentration of synthetic estradiol and progestogens (OC, n ϭ 11), or non-OC-users tested in the follicular phase of the menstrual cycle characterized by low concentrations of estradiol and progesterone (control, n ϭ 12). Subjects performed 1 h of one-legged kicking exercise. The next day collagen fractional synthesis rates (FSR) in tendon and muscle connective tissue were measured after a flooding dose of [ 13 C]proline followed by biopsies from the patellar tendon and vastus lateralis in both legs. Simultaneously, microdialysis catheters were inserted in vastus lateralis and in front of the patellar tendon for measurement of insulin-like growth factor I (IGF-I) and its binding proteins. Serum NH 2-terminal propeptide of type I collagen (PINP) and urine COOHterminal telopeptides of type-I collagen (CTX-I) were measured as markers for bone synthesis and breakdown, respectively. Tendon FSR and PINP were lower in OC compared with control. An increase in muscle collagen FSR postexercise was only observed in control (P Ͻ 0.05). Furthermore, the results indicate a lower bioavailability of IGF-I in OC. In conclusion, synthetic female sex hormones administered as OC had an inhibiting effect on collagen synthesis in tendon, bone, and muscle connective tissue, which may be related to a lower bioavailability of IGF-I. estrogen; exercise; insulin-like growth factor I; ethinyl estradiol; bone COLLAGEN is the most abundant protein in the human body and comprises a very high fraction of the tissue organic mass in bone (90%), tendon (60 -85%), ligament (70%), and intramuscular connective tissue (ϳ30% and up to 90%) (31, 57). The frequency of several diseases linked to collagen-rich tissue seems to be biased by sex (30,34,36,65). Furthermore, women are at a greater risk than men for sustaining certain kinds of soft tissue sports injuries (7, 24, 26). Several epidemiological studies have shown that women have up to six times greater risk of anterior cruciate ligament (ACL) ruptures than activity-matched men (24). It has been suggested that sex hormones may influence collagen turnover, tissue composition, and biomechanical properties of the tissues, which in part may explain sex-specific differences in risk (24). In support of this, tendon collagen synthesis is lower in women compared with men at rest and after exercise (47). In addition, a lower p...

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“…26 -29 OC use has been reported to influence the collagen metabolism. 30 Some authors consider LBPP during pregnancy to be a normal condition of pregnancy. 31,32 The symptoms may vary highly, and individuals are affected to different degrees.…”

mentioning

confidence: 99%

Low Back Pain and Pelvic Pain During Pregnancy

Mogren

Pohjanen²

2005

Spine

297

312

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Collagen metabolism markers as a reflection of bone and soft tissue turnover during the menstrual cycle and oral contraceptive use

Cited by 28 publications

References 37 publications

Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women

Low Back Pain and Pelvic Pain During Pregnancy

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